Extracellular vesicle-mediated bidirectional communication between the liver and other organs: mechanistic exploration and prospects for clinical applications
Wenhui Mo,
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Yunke Peng,
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Yanyi Zheng
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et al.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 8, 2025
The
liver,
functioning
as
an
endocrine
organ,
secretes
a
variety
of
substances
that
influence
the
activities
other
body
organs.
Conversely,
molecules
generated
by
organs
such
bone,
gut,
and
adipose
tissue
can
also
impact
liver
function.
Accumulating
evidence
suggests
bidirectional
communication
between
However,
research
on
how
extracellular
vesicles
(EVs),
which
transport
active
molecular
mediators,
contribute
to
this
interorgan
is
still
in
its
nascent
stages.
EVs
are
capable
transporting
functional
molecules,
including
lipids,
nucleic
acids,
proteins,
thereby
affecting
recipient
cells
across
different
at
biological
level.
This
review
examines
role
facilitating
cardiovascular
system,
pancreas,
brain,
lungs,
kidneys,
tissue.
It
explores
their
potential
disease
treatment
highlights
challenges
understanding
EV-mediated
interactions.
contribution
mediator-carrying
two-way
remains
area
ongoing
investigation.
Future
will
provide
more
comprehensive
theoretical
foundation
clarify
precise
mechanisms
governing
organs,
pinpoint
medical
targets,
expand
application
within
realm
precision
medicine.
Language: Английский
New insights into T cell metabolism in liver cancer: from mechanism to therapy
Cell Death Discovery,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 23, 2025
Abstract
Liver
cancer
is
the
sixth
most
common
worldwide
and
third
cause
of
mortality.
The
development
progression
liver
metastases
a
multifaceted
process
involving
numerous
metabolic
pathways.
T
cells
have
protective
role
in
defense
against
cancer,
manipulating
pathways
can
alter
their
antitumor
activity.
Furthermore,
cell
nutrition
competition
lead
to
dysfunction
through
various
molecular
mechanisms.
Some
nanomaterials
drugs
improve
metabolism
promote
anti-liver
function
cells.
This
review
discusses
current
literature
regarding
changes
targeted
therapy
for
cancer.
promise
challenges
studying
target
treating
are
also
addressed.
Targeting
promising
approach
Language: Английский
Recent advances in the role of mesenchymal stem cells as modulators in autoinflammatory diseases
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 20, 2024
Mesenchymal
stem
cells
(MSCs),
recognized
for
their
self-renewal
and
multi-lineage
differentiation
capabilities,
have
garnered
considerable
wide
attention
since
discovery
in
bone
marrow.
Recent
studies
underscored
the
potential
of
MSCs
immune
regulation,
particularly
context
autoimmune
diseases,
which
arise
from
system
imbalances
necessitate
long-term
treatment.
Traditional
immunosuppressive
drugs,
while
effective,
can
lead
to
drug
tolerance
adverse
effects,
including
a
heightened
risk
infections
malignancies.
Consequently,
adjuvant
therapy
incorporating
has
emerged
as
promising
new
treatment
strategy,
leveraging
immunomodulatory
properties.
This
paper
reviews
mechanisms
application
highlighting
regulate
responses
reduce
inflammation.
The
are
primarily
mediated
through
direct
cell
contact
paracrine
activity
with
cells.
review
lays
groundwork
broader
clinical
future
underscores
significant
scientific
value
prospects.
Further
research
is
expected
enhance
efficacy
safety
MSCs-based
treatments
diseases.
Language: Английский
Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1353 - 1353
Published: Oct. 24, 2024
Autoimmune
hepatitis
(AIH)
is
an
immune-mediated
liver
disease
that
currently
faces
limited
treatment
options.
In
its
advanced
stages,
AIH
can
progress
to
fibrosis
and
cirrhosis.
Recent
research
has
increasingly
focused
on
cell-free
therapies,
particularly
the
use
of
mesenchymal
stem
cell
(MSC)-derived
exosomes
(Exos),
which
have
shown
promise
in
treating
autoimmune
diseases,
including
AIH.
MSC-Exos,
as
microvesicles
with
low
immunogenicity,
high
safety,
permeability,
deliver
RNA,
DNA,
proteins,
lipids,
various
drugs
for
treatment,
showing
promising
clinical
application
prospects.
This
review
provides
a
comprehensive
summary
current
MSC-Exos
explores
underlying
molecular
mechanisms
involved.
It
highlights
significant
regulatory
effects
immune
cells
their
ability
modify
microenvironment,
demonstrating
anti-inflammatory
anti-fibrotic
properties
while
promoting
regeneration.
Additionally,
this
also
discusses
potential
challenges
future
strategies
advancing
Exo-based
therapies
Language: Английский