Improvement of Estrogen Deficiency Symptoms by the Intake of Long-Term Fermented Soybeans (Doenjang) Rich in Bacillus Species through Modulating Gut Microbiota in Estrogen-Deficient Rats DOI Creative Commons
Ting Zhang, Yue Yu, Su-Ji Jeong

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(6), P. 1143 - 1143

Published: March 8, 2023

Traditionally made doenjang (TMD) produced by the long-term fermentation of soybeans with salt may improve symptoms estrogen deficiency. We aimed to evaluate effects four TMD types, containing low and high amounts Bacillus species biogenic amines (HBHA, HBLA, LBHA, LBLA), on energy, glucose, lipid metabolism, altering gut microbiota in estrogen-deficient ovariectomized (OVX) rats. Their mechanisms were also examined. The OVX rats divided into control, cooked soybean (CSB), HBHA, LBLA groups. Sham-operated normal control group. Serum 17β-estradiol concentrations similar among all Tail skin temperatures, which are indicative hot flashes, higher than HBHA HBLA groups Weight gain visceral fat mass lower CSB intake but not as Lean body showed a trend opposite that respective hepatic triglyceride content decreased compared mRNA expressions peroxisome proliferator-activated receptor-γ (PPAR-γ) carnitine palmitoyltransferase-1 group, PPAR-γ expression was more elevated group morphology intestines improved an enhanced improvement LBHA increased α-diversity cecal control. Akkermenia Lactobacillus estrogen, forkhead box proteins class-O subgroup, insulin-signaling pathways prevented their decrement. In conclusion, treatment potentially improves deficiency unfermented soybeans.

Language: Английский

The effects of hormone replacement therapy on the microbiomes of postmenopausal women DOI

Marisol I. Dothard,

Sarah M. Allard, Jack A. Gilbert

et al.

Climacteric, Journal Year: 2023, Volume and Issue: 26(3), P. 182 - 192

Published: April 13, 2023

The sex steroid hormone estrogen plays a number of regulatory roles in female development. During menopause, synthesis the ovaries decreases, which results adverse physiological remodeling and increased risk disease. Reduced bone density, changes community composition profiles gut vaginal microbiome, mood swings environment are to be expected during this time. To alleviate these changes, postmenopausal women can prescribed replacement therapy (HRT) through use exogenous estradiol, often conjunction with progestin treatment, re-induces estrogenic action throughout body. microbiome have bidirectional, relationship gut, while works indirectly on restoring tissue that leads microbial homeostasis. This review discusses what is known about how microbiomes responding HRT, potential future microbe-based therapeutics for symptoms menopause.

Language: Английский

Citations

12
Antibiotic-perturbed microbiota and the role of probiotics DOI
Hania Szajewska, Karen P. Scott,

Tim de Meij

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 22(3), P. 155 - 172

Published: Dec. 11, 2024

Language: Английский

Citations

4
Sex Hormones–Gut Microbiome Axis: An Update of What Is Known So Far DOI
Mohamed Zommiti, Marc Feuilloley

Current Opinion in Endocrine and Metabolic Research, Journal Year: 2025, Volume and Issue: unknown, P. 100571 - 100571

Published: Jan. 1, 2025

Language: Английский

Citations

0
Hormonal Environment Shapes the Oral Microbiome DOI
Maria J. Rus, Carlos Carballo, Flávio Duarte Faria

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 225 - 242

Published: Jan. 1, 2025

Language: Английский

Citations

0
MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women DOI Creative Commons
Ilaria Milani,

Marianna Chinucci,

Frida Leonetti

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855

Published: April 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Language: Английский

Citations

0
Exogenous acetate mitigates later enhanced allergic airway inflammation in a menopausal mouse model DOI Creative Commons

Evelyn Roxana Perez Umana,

Eduardo Mendes, Mateus B. Casaro

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 10, 2025

Introduction Asthma, an inflammatory lung disease, disproportionately affects women in adulthood and is associated with a decline estrogen levels during the menstrual cycle menopause. To study asthma symptoms menopause, we used mouse model of postmenopausal via ovariectomy (OVx). Similar to human previously discovered that re-exposure allergic OVx mice allergen exacerbates inflammation. Surprisingly, found probiotic treatment alleviates this exacerbation produces acetate as one its metabolites. Here, investigate whether exogenous alone can inhibit experimental Methods Mice received administration before sensitization. After challenge were subjected second test protected against airway inflammation after menopause induction. Results Acetate reduced all T2 responses, well serum immunoglobulin (IgE) level. Early led increase regulatory T cells, even 3 weeks cessation treatment, suggesting Treg percentage reduction type 2 airways induction, indicating potential role process. Given significant lung-gut axis association intestinal dysfunctions, finding particularly relevant; also analyzed several markers integrity. Compared sham-operated mice, rechallenged menopausal had epithelial genes, MUC2 OCLN, preventive supplementation returned their expression normal. No change was without Conclusion In conclusion, prior level protects sensitized challenged later may restore gut homeostasis.

Language: Английский

Citations

0
Gut microbiota development across the lifespan: Disease links and health‐promoting interventions DOI Creative Commons
Ida Schoultz, Marcus J. Claesson, Maria Gloria Dominguez‐Bello

et al.

Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract The gut microbiota plays a pivotal role in human life and undergoes dynamic changes throughout the lifespan, from infancy to old age. During our life, influences health disease across stages. This review summarizes discussions presentations symposium “Gut development age” held collaboration with Journal of Internal Medicine. In early infancy, microbial colonization is shaped by factors such as mode delivery, antibiotic exposure, milk‐feeding practices, laying foundation for subsequent increased diversity maturation. Throughout childhood adolescence, maturation continues, influencing immune metabolic health. adulthood, reaches relatively stable state, influenced genetics, diet, lifestyle. Notably, disruptions composition have been implicated various inflammatory diseases—including bowel disease, Type 1 diabetes, allergies. Furthermore, emerging evidence suggests connection between dysbiosis neurodegenerative disorders Alzheimer's disease. Understanding pathogenesis stages provides insights into potential therapeutic interventions. Probiotics, prebiotics, dietary modifications, well fecal transplantation, are being explored promising strategies promote healthy mitigate risks. focuses on microbiota's aging, addressing its development, stability, alterations linked these critical It outlines future research directions aimed at optimizing improve

Language: Английский

Citations

0
Gut microbiome influences incidence and outcomes of breast cancer by regulating levels and activity of steroid hormones in women DOI Creative Commons
Shilpa S. Chapadgaonkar,

Srashti Bajpai,

Mukul Godbole

et al.

Cancer Reports, Journal Year: 2023, Volume and Issue: 6(11)

Published: June 13, 2023

Abstract Background Breast cancer, the leading cancer type in women worldwide, is affected by reproductive and nonreproductive factors. Estrogen progesterone influence incidence progression of breast cancer. The microbiome gut, a complex organ that plays vital role digestion homeostasis, enhances availability estrogen host. Thus, an altered gut may hormone‐induced incidence. This review describes current understanding roles influencing with emphasis on microbiome‐induced metabolism progesterone. Recent Findings Microbiome has been recognized as promising hallmark Next‐generation sequencing technologies have aided rapid identification components are capable metabolizing Moreover, studies indicated wider chemotherapeutic hormonal therapy agents reducing their efficacy patients predominant effect postmenopausal women. Conclusion variations its composition significantly alter outcomes healthy diverse required for better response to anticancer therapies. Finally, emphasizes requirement elucidate mechanisms aid improving composition, hence, survival

Language: Английский

Citations

10
Estrogen deficiency in the menopause and the role of hormone therapy: integrating the findings of basic science research with clinical trials DOI

Jane L. Yang,

Emmanuelle Hodara, Intira Sriprasert

et al.

Menopause The Journal of The North American Menopause Society, Journal Year: 2024, Volume and Issue: 31(10), P. 926 - 939

Published: July 30, 2024

Menopause, defined by the cessation of menstrual cycles after 12 months amenorrhea not due to other causes, is associated with significant hormonal changes, primarily a decrease in estrogen, androgen, and progesterone levels. This review delves into effects estrogen deficiency during perimenopausal transition postmenopause, integrating findings basic science clinical trials. Here, we first outline variation endogenous estrogens before menopause, exploring both genomic nongenomic actions its receptors throughout body. Next, detail spectrum menopausal symptoms, from acute vasomotor, urogenital, psychological issues perimenopause chronic reproductive, cardiovascular, neurological, skeletal, dermatologic, immune, digestive changes postmenopause. Finally, evaluate role hormone therapy alleviating these weighing benefits against known risks. Publicizing an accurate representation risks replacement our aging patients fundamental improving their care, quality, even quantity life.

Language: Английский

Citations

3
Sex Hormones, the Stool Microbiome, and Subclinical Atherosclerosis in Women With and Without HIV DOI
Brandilyn A. Peters, David B. Hanna, Yi Wang

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(2), P. 483 - 497

Published: Aug. 29, 2023

Abstract Context Cardioprotective roles of endogenous estrogens may be particularly important in women with HIV, who have reduced estrogen exposure and elevated cardiovascular disease risk. The gut microbiome metabolically interacts sex hormones, but little is known regarding possible impact on Objective To analyze potential interplay hormones Methods Among 197 postmenopausal the Women's Interagency HIV Study, we measured 15 serum assessed stool. Presence carotid artery plaque was determined (B-mode ultrasound) a subset (n = 134). We examined associations (i) stool microbiome, (ii) plaque, (iii) hormone–related microbiota adjusting for confounders. Results Participant median age 58 years majority were living (81%). Sex (estrogens, androgens, adrenal precursors) associated diversity specific species, similarly without HIV. Estrogens higher diversity, abundance species from Alistipes, Collinsella, Erysipelotrichia, Clostridia, microbial β-glucuronidase aryl-sulfatase orthologs, which are involved hormone metabolism. Several lower odds including dihydrotestosterone, 3α-diol-17G, estradiol, estrone. Exploratory mediation analysis suggested that estrone-related mediate protective association estrone plaque. Conclusion Serum significant predictors composition. play role estrogen-related protection.

Language: Английский

Citations

9