International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113608 - 113608
Published: Nov. 15, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10041 - 10041
Published: Sept. 18, 2024
The objective of this review is to provide a comprehensive examination the role microbial metabolites in progression neurodegenerative diseases, as well investigate potential therapeutic interventions targeting microbiota. A literature search was conducted across following databases: PubMed, Scopus, Web Science, ScienceDirect, and Wiley. Key terms related gut microbiota, metabolites, specific metabolic products were used. included both preclinical clinical research articles published between 2000 2024. Short-chain fatty acids have been demonstrated play crucial modulating neuroinflammation, preserving integrity blood–brain barrier, influencing neuronal plasticity protection. Furthermore, amino their derivatives exert significant influence on CNS function. These impact health by regulating intestinal permeability, immune responses, directly neuroinflammation oxidative stress, which are integral diseases. Therapeutic strategies, including prebiotics, probiotics, dietary modifications, fecal microbiota transplantation confirmed restore balance enhance production neuroprotective metabolites. novel drug developments based present promising avenues. its represent field with advance our understanding develop treatments for
Language: Английский
Citations
6
International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 529 - 565
Published: Feb. 1, 2025
Abstract: Allergic rhinitis (AR) is a prevalent allergic disease that imposes significant economic burdens and life pressures on individuals, families, society, particularly in the context of accelerating globalization increasing pathogenic factors. Current clinical therapies for AR include antihistamines, glucocorticoids administered via various routes, leukotriene receptor antagonists, immunotherapy, several decongestants. These treatments have demonstrated efficacy alleviating symptoms pathological states. However, with growing awareness rising expectations improvements quality life, these become associated higher incidence side effects an elevated risk drug resistance. Furthermore, development intricately dysregulation immune system, yet underlying pathogenetic mechanisms remain incompletely understood. In contrast, widely available natural plant molecules offer multiple targeting pathways uniquely modify typical pathophysiology through immunomodulatory processes. This review presents comprehensive analysis both vivo vitro studies modulate immunity treating AR. Additionally, we examine their specific action animal models to provide new insights developing safe effective targeted while guiding experimental applications against Keywords: molecules, rhinitis, immunomodulation, therapeutic mechanism, research progress
Language: Английский
Citations
0
Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 175 - 175
Published: April 17, 2025
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, yet effective agents for its prevention and therapy remain highly limited. Epicoccin A, a significant secondary metabolite from Exserohilum sp., demonstrates various biological activities; however, neuroprotective effects have not been elucidated. Here, we investigated therapeutic potential of epicoccin A PD by evaluating impact on neural phenotype, reactive oxygen species (ROS) generation, locomotor activity in PD-like zebrafish. Transcriptomic analysis molecular docking were conducted, with key gene expressions further verified using real-time qPCR. As result, notably mitigated dopaminergic neuron loss, vasculature deficiency, nervous system injury, ROS accumulation, impairments, abnormal hallmark genes associated oxidative stress. Underlying mechanism investigation indicated may alleviate symptoms activating PINK1/Parkin-dependent mitophagy, as evidenced reversal aberrant related to pink1/parkin pathway upstream mTOR/FoxO following co-treatments. This finding was confirmed robust interactions between these mitophagy regulators. Our results suggest that relieves pink1/parkin-dependent inhibiting excessive stress, highlighting approach PD.
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Nov. 1, 2024
The role of interleukin-18 (IL-18) and inflammasomes in chronic inflammatory airway diseases, such as asthma obstructive pulmonary disease (COPD), has garnered significant attention recent years. This review aims to provide an overview the current understanding IL-18 biology, associated signaling pathways, involvement inflammasome complexes diseases. We explore multifaceted pathophysiology, including its interactions with other cytokines contributions both T2 non-T2 inflammation. Importantly, emerging evidence highlights a critical player severe asthma, contributing inflammation, hyperresponsiveness (AHR), mucus impaction. Furthermore, we discuss IL-18's autoimmunity highlight potential therapeutic targets within pathways patients infections autoimmune responses. By synthesizing advancements ongoing research, this underscores importance novel target treatment related conditions.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113608 - 113608
Published: Nov. 15, 2024
Language: Английский
Citations
0