Cell Division, Journal Year: 2024, Volume and Issue: 19(1)
Published: Sept. 11, 2024
Language: Английский
Hepatology Research, Journal Year: 2024, Volume and Issue: 54(8), P. 763 - 772
Published: April 18, 2024
A nationwide survey in 2018 showed decreasing involvement of viral hepatitis and increasing nonviral liver diseases the etiology cirrhosis (LC) Japan. An updated was undertaken 2023.
Language: Английский
Citations
17
Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1245 - 1245
Published: July 24, 2024
Circular RNAs (circRNAs) are cardinal players in numerous physiological and pathological processes. CircRNAs play dual roles as tumor suppressors oncogenes different oncological contexts, including hepatocellular carcinoma (HCC). Their significantly impact the disease at all stages, initiation, development, progression, invasion, metastasis, addition to response treatment. In this review, we discuss biogenesis regulatory functional of circRNAs, well circRNA-protein-mRNA ternary complex formation, elucidating intricate pathways tuned by circRNAs modulate gene expression cellular processes through a comprehensive literature search, silico bioinformatics analysis. With particular focus on interplay between epigenetics, HCC pathology, article sets stage for further exploration novel investigational theranostic agents dynamic realm HCC.
Language: Английский
Citations
9
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118430 - 118430
Published: June 8, 2024
Language: Английский
Citations
7
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 196, P. 104312 - 104312
Published: Feb. 28, 2024
Language: Английский
Citations
6
Jurnal Online Informatika, Journal Year: 2024, Volume and Issue: 9(1), P. 70 - 79
Published: April 26, 2024
This study aims to provide an overview of the current state-of-the-art applications artificial intelligence (AI) and machine learning in management hepatocellular carcinoma (HCC), explore future directions for continued progress this emerging field. is a comprehensive literature review that synthesizes recent findings advancements application AI techniques across various aspects HCC care, including screening early detection, diagnosis staging, prognostic modeling, treatment planning, interventional guidance, monitoring response. The draws upon wide range published research studies, focusing on integration with diverse data sources, such as medical imaging, clinical data, genomics, other multimodal information. results demonstrate AI-based systems have shown promise improving accuracy efficiency screening, diagnosis, tumor characterization compared traditional methods. Machine models integrating clinical, genomic outperformed conventional staging predicting survival recurrence risk. recommendation potential optimize personalized therapy selection, while augmented reality can guide procedures real-time. Moreover, longitudinal may enhance assessment response monitoring. Despite these promising findings, highlights need rigorous multicenter prospective validation standardized datasets, thoughtful consideration ethical implications before widespread implementation technologies management.
Language: Английский
Citations
5
Cancers, Journal Year: 2023, Volume and Issue: 15(21), P. 5178 - 5178
Published: Oct. 27, 2023
Hepatocellular carcinoma (HCC) is a predominant malignancy with increasing incidences and mortalities worldwide. In Western countries, the progressive affirmation of Non-alcoholic Fatty Liver Disease (NAFLD) as main chronic liver disorder in which HCC occurrence appreciable even non-cirrhotic stages, constitutes real health emergency. light this, further comprehension molecular pathways supporting onset progression represents current research challenge to achieve more tailored prognostic models appropriate therapeutic approaches. RNA non-coding transcripts (ncRNAs) are involved regulation several cancer-related processes, including HCC. When dysregulated, these molecules, conventionally classified "small ncRNAs" (sncRNAs) "long (lncRNAs) have been reported markedly influence HCC-related mechanisms. this review, we describe dysregulated ncRNAs relative progression, analyzing their implications certain etiologically related contexts, applicability clinical practice novel diagnostic, prognostic, tools. Finally, given growing evidence immune system response, oxidative stress-regulated mechanisms, gut microbiota composition relevant emerging elements mutually influencing liver-cancerogenesis investigate relationship triad, shedding on pathogenetic frontiers progression.
Language: Английский
Citations
12
Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 325 - 325
Published: June 8, 2024
Epigenetic and metabolic reprogramming alterations are two important features of tumors, their reversible, spatial, temporal regulation is a distinctive hallmark carcinogenesis. Epigenetics, which focuses on gene regulatory mechanisms beyond the DNA sequence, new entry point for tumor therapy. Moreover, drives hepatocellular carcinoma (HCC) initiation progression, highlighting significance metabolism in this disease. Exploring inter-regulatory relationship between epigenetic modification has become one hot directions current research. As viral etiologies have given way to dysfunction-associated steatotic liver disease (MASLD)-induced HCC, it urgent that complex molecular pathways linking them hepatocarcinogenesis be explored. However, how aberrant crosstalk modifications affects MASLD-induced HCC lacks comprehensive understanding. A better understanding linkages necessary improve treatment strategies. For reason, review examines interwoven landscape carcinogenesis context focusing regulating development interactions while also updating advances modification-based therapeutic drugs HCC.
Language: Английский
Citations
4
Current Oncology Reports, Journal Year: 2024, Volume and Issue: 26(11), P. 1452 - 1468
Published: Oct. 10, 2024
Language: Английский
Citations
4
Biological Procedures Online, Journal Year: 2025, Volume and Issue: 27(1)
Published: Feb. 27, 2025
Hepatocellular carcinoma (HCC) is a prevalent malignancy worldwide, characterized by its high and poor prognosis. Telomeres, crucial components of eukaryotic chromosomes, have been increasingly recognized for their involvement in tumorigenesis, development, impact on the prognosis cancer patients. However, precise role telomere-associated genes HCC remains incompletely elucidated. The Cancer Genome Atlas (TCGA) database was utilized to download data from 374 50 normal liver tissue samples. Differential were screened intersected with 2093 telomere-related (TRGs) GeneCards, resulting identification 704 TRGs exhibiting survival differences. Through univariate Cox regression analysis, multivariate LASSO regression, prognostic model consisting 18 risk assessment developed. single-cell spatial transcriptomics analyze expression distribution HCC. Subsequently, Mendelian randomization (MR) analysis confirmed causal relationship between ASF1A alcoholic among identified TRGs. functional significance cell lines investigated through colony formation assays, Transwell migration wound healing experiments. We developed incorporating Kaplan–Meier demonstrated that overall (OS) rate high-risk group significantly inferior low-risk group. age (HR = 1.017, 95% CI: 1.002–1.032, P 0.03), stage 1.389, 1.111–1.737, 0.004), score 5.097, 3.273–7.936, < 0.001) as three independent factors five-year receiver operating characteristic curve (ROC) further validated accuracy our model. Time-dependent ROC results revealed 1-year, 3-year, 5-year AUC values 0.801, 0.734, 0.690, respectively. data. Additionally, immune subtype indicated lower proportion C3 C4 subtypes TRG compared Meanwhile, tumor dysfunction exclusion (TIDE) higher than Furthermore, we observed differences IC50 nine chemotherapeutic drugs across different which partially model's predictive efficacy immunotherapy. Amongst these eighteen analyzed MR found be associated pathogenesis. significant overexpression Western blotting. also explored it's carcinogenic via transwell, healing, clone In this study, novel comprising HCC, exhibited remarkable predicting patients' successfully established first time, provided new theoretical foundation management
Language: Английский
Citations
0
Life, Journal Year: 2025, Volume and Issue: 15(3), P. 403 - 403
Published: March 4, 2025
During the coronavirus disease 2019 (COVID-19) pandemic, several studies highlighted a worse prognosis for patients with alterations in liver function tests, especially those pre-existing diseases. However, further are needed to define long-term impact of COVID-19 pandemic on Long encompasses wide range signs and symptoms, including exacerbations chronic conditions or new onset developed after acute phase. Therefore, effects extensively include hepatic manifestations. The co-expression angiotensin-converting receptor 2 (ACE2) transmembrane serine protease (TMPRSS2) has been demonstrated also enterocytes, cholangiocytes, hepatocytes. Studies post-COVID-19 sequelae have shown presence steatosis necroinflammation liver, concomitantly an alteration inflammation, cytolysis cholestasis indices. Some increased risk hepatobiliary pathologies, secondary biliary cholangitis worsening severity metabolic-associated fatty (MASLD). Based these premises, this review aims provide overview pathophysiological mechanisms contributing COVID-19-related damage; explore its implications inflammation fibrosis, particular focus MASLD metabolic dysfunction-associated steatohepatitis (MASH); analyze short- sequelae. A literature search was conducted using PubMed database relevant published English.
Language: Английский
Citations
0