Pharmaceuticals,
Journal Year:
2022,
Volume and Issue:
15(11), P. 1372 - 1372
Published: Nov. 8, 2022
Dexmedetomidine
(DEX)
is
a
commonly
used
sedative
agent
with
no
or
minimal
effects
on
breathing.
DEX
may
also
be
beneficial
in
myocardial
protection.
Since
the
mechanisms
of
cardiac
are
not
well
known,
we
carried
out
descriptive
review
and
examined
electrical
conduction
prospective
controlled
manner.
For
review,
clinical
studies
exploring
protection
published
between
2020-2022
were
explored.
A
case
study
included
11
consecutive
patients
at
median
(range)
age
48
(38-59),
scheduled
for
elective
radiofrequency
ablation
paroxysmal
atrial
fibrillation.
bolus
dose
1
µg/kg
given
15
min
was
followed
by
continuous
infusion
0.2-0.7
µg/kg/h.
Direct
intracardiac
electrophysiologic
measurements,
hemodynamics
oxygenation
measured
before
after
bolus.
Experimental
show
that
protects
heart
both
via
stabilizing
electrophysiology
reducing
apoptosis
autophagy
cell
injury.
The
evidence
shows
provides
during
different
surgeries.
In
study,
increased
corrected
sinus
node
recovery
time,
prolongated
atrioventricular
(AV)
nodal
refractory
period
cycle
length
producing
AV
Wenckebach
retrograde
block.
has
putative
role
organ
against
hypoxic,
oxidative
reperfusion
slows
down
firing
prolongs
refractoriness.
Actas Españolas de Psiquiatría,
Journal Year:
2024,
Volume and Issue:
52(1), P. 19 - 27
Published: Feb. 5, 2024
Background:
The
protective
mechanism
of
dexmedetomidine
on
the
brains
patients
undergoing
craniocerebral
surgery
remains
unclear.
aim
this
study
was
to
examine
impact
cognitive
function,
oxidative
stress,
and
brain
protection
in
such
patients.
Methods:
Fifty-four
who
underwent
at
our
hospital
from
January
2020
June
2023
were
retrospectively
selected
as
subjects.
They
divided
into
two
groups:
control
group
(n
=
27)
27),
based
different
auxiliary
anesthesia
protocols.
Patients
received
before
induction,
using
a
midline
intravenous
pump
assist
anesthesia,
while
an
equivalent
amount
normal
saline.
remaining
induction
maintenance
protocols
consistent
for
both
groups.
Cognitive
function
assessed
Mini
Mental
State
Examination
(MMSE)
1
day
after
Oxidative
stress
indicators,
including
malondialdehyde
(MDA),
glutathione
peroxidase
(GSH-Px),
superoxide
dismutase
(SOD)
levels
serum
groups,
measured
enzyme-linked
immunosorbent
assay
(ELISA).
Additionally,
changes
postoperative
injury
namely
neuron-specific
enolase
(NSE)
central
nervous
system-specific
protein
(S100β),
detected
compared
Concurrently,
adverse
reactions
recorded
Results:
MMSE
scale
scores
groups
24
hours
significantly
lower
than
those
surgery.
However,
notably
higher
group,
with
statistically
significant
difference
(p
<
0.05).
One
hour
surgery,
MDA,
GSH-Px,
SOD
elevated
pre-surgery
levels.
Yet,
exhibited
comparison
these
differences
NSE
S100β
markedly
preoperative
demonstrated
incidence
complications
7.41%
(2/27),
indicating
decreasing
trend
18.52%
(5/27)
group.
did
not
reach
statistical
significance
(χ2
1.477,
p
0.224).
Conclusion:
Dexmedetomidine-assisted
can
effectively
enhance
mitigate
facilitate
overall
recovery
intervention
exhibits
favorable
safety
profile
no
reported
serious
reactions,
establishing
it
relatively
safe
reliable
approach.
CNS Spectrums,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 10
Published: Nov. 20, 2024
This
study
aimed
to
investigate
the
effects
of
esketamine
(Esk)
combined
with
dexmedetomidine
(Dex)
on
postoperative
delirium
(POD)
and
quality
recovery
(QoR)
in
elderly
patients
undergoing
thoracoscopic
radical
lung
cancer
surgery.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(23), P. 7264 - 7264
Published: Nov. 29, 2024
Background:
Opioid-sparing
anesthesia
(OSA)
using
dexmedetomidine
has
gained
attention
as
an
alternative
to
opioid-based
(OBA)
due
its
potential
reduce
opioid
consumption
and
the
associated
side
effects.
This
study
aimed
investigate
effect
of
dexmedetomidine-based
OSA
on
postoperative
pain
intensity,
consumption,
recovery
outcomes
in
patients
undergoing
a
minimally
invasive
repair
pectus
excavatum.
Methods:
Eighty-four
excavatum
were
randomized
either
group,
receiving
dexmedetomidine,
or
OBA
remifentanil.
The
primary
outcome
was
total
amount
analgesics
administered
within
24
h
postoperatively.
secondary
included
intensity
analgesic
over
48
h,
outcomes,
intraoperative
hemodynamics,
opioid-related
complications.
Results:
OFA
group
reported
significantly
reduced
morphine-equivalent
dose
(55.4
±
31.1
mg
vs.
80.2
26.7
mg,
p
<
0.001)
lower
VAS
scores
at
(3.9
1.5
5.4
2.1,
0.001).
Pain
lower,
1–6,
6–24,
24–48
after
surgery.
Recovery
times
hemodynamics
comparable
between
groups,
with
no
significant
differences
Conclusions:
Dexmedetomidine-based
effectively
reduces
use
without
compromising
hemodynamic
stability.
These
findings
support
viable
OBA,
particularly
Pharmaceuticals,
Journal Year:
2022,
Volume and Issue:
15(11), P. 1372 - 1372
Published: Nov. 8, 2022
Dexmedetomidine
(DEX)
is
a
commonly
used
sedative
agent
with
no
or
minimal
effects
on
breathing.
DEX
may
also
be
beneficial
in
myocardial
protection.
Since
the
mechanisms
of
cardiac
are
not
well
known,
we
carried
out
descriptive
review
and
examined
electrical
conduction
prospective
controlled
manner.
For
review,
clinical
studies
exploring
protection
published
between
2020-2022
were
explored.
A
case
study
included
11
consecutive
patients
at
median
(range)
age
48
(38-59),
scheduled
for
elective
radiofrequency
ablation
paroxysmal
atrial
fibrillation.
bolus
dose
1
µg/kg
given
15
min
was
followed
by
continuous
infusion
0.2-0.7
µg/kg/h.
Direct
intracardiac
electrophysiologic
measurements,
hemodynamics
oxygenation
measured
before
after
bolus.
Experimental
show
that
protects
heart
both
via
stabilizing
electrophysiology
reducing
apoptosis
autophagy
cell
injury.
The
evidence
shows
provides
during
different
surgeries.
In
study,
increased
corrected
sinus
node
recovery
time,
prolongated
atrioventricular
(AV)
nodal
refractory
period
cycle
length
producing
AV
Wenckebach
retrograde
block.
has
putative
role
organ
against
hypoxic,
oxidative
reperfusion
slows
down
firing
prolongs
refractoriness.
