Double-Blind, Randomized, Controlled Pilot Trial to Specify Collateral Effect and Safety of Perioperative Dexmedetomidine in Patients Undergoing Open Heart Surgery

Anesthesiology and Pain Medicine, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

Background: This study aimed to assess the collateral effects and safety of dexmedetomidine (Dex) during one day after surgery in Iranian patients undergoing open heart surgery, expand clinical applications Dex Iran. Methods: pilot was conducted Gorgan, Golestan province, Iran, 2024. Both male female participants were randomly assigned either group (n = 10), receiving 0.5 µg/kg/h along with standard anesthesia management, or control 10). The primary outcome percentage experiencing adverse events. Secondary outcomes included stability hemodynamic respiratory parameters, occurrence arrhythmias, biological changes assessed 24 hours surgery. Results: Out 45 participants, 20 enrolled analyzed. comparison between groups showed that observed higher (4 patients) compared (1 patient), common events being hypotension, bradycardia, tachycardia. Biological markers, such as lactate blood sugar (BS), increased both groups, showing a greater increase BS levels (P 0.012 P 0.009, respectively) 0.017 0.093, respectively). Additionally, there no significant differences markers > 0.05); however, improved preserved more effectively. Conclusions: addition protocol safe without events, promising role improving cardiac function

Language: Английский

---

Dexmedetomidine challenge to uncover an intermittent accessory pathway

HeartRhythm Case Reports, Journal Year: 2024, Volume and Issue: 10(4), P. 283 - 287

Published: Feb. 8, 2024

Ventricular pre-excitation is characterized by the presence of a delta wave, short PR interval and an increased duration QRS on electrocardiogram (EKG); prevalence this EKG pattern has been estimated at one to three individuals per 1,000 persons1. However, true likely under-represented because least half known patients do not develop symptoms or conductance through accessory pathway (AP) could be intermittent. In selected cases, such as high-risk occupations professional drivers, athletes1, according informed patient choice2, ablation "low risk" intermittent AP considered.

Language: Английский

---

Impact of dexmedetomidine on electrophysiological properties and arrhythmia inducibility in adult patients referred for reentrant supraventricular tachycardia ablation

Journal of Interventional Cardiac Electrophysiology, Journal Year: 2023, Volume and Issue: 67(2), P. 371 - 378

Published: Sept. 29, 2023

Language: Английский

---

Dexmedetomidine Ameliorates X-Ray-Induced Myocardial Injury Via Alleviating Cardiomyocyte Apoptosis and Autophagy

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 19, 2024

Abstract Background Radiotherapy is one of the major local treatments for tumors. However, some complications may occur during treatment, which includes radiation-induced heart disease (RIHD). there no uniform standard prevention RIHD currently. Dexmedetomidine reported to have cardio protection effects, while its role in myocardial injury unknown. In current study, we aimed evaluate radioprotective effect dexmedetomidine X-ray radiation-treated mice. Methods 9 male mice were randomized into 3 groups: control, 16Gy, and 16Gy + Dex. The group was exposed a single dose radiation. Dex pretreated with before control treated saline did not receive tissues collected 16 weeks after radiation subjected hematoxylin-eosin (HE) staining, TUNEL immunohistochemistry (IHC) staining. Besides, established radiation-injured cardiomyocyte model. Cell viability assessed CCK-8 assay cell apoptosis using flow cytometry. Protein expression Bcl-2, Bax, LC3 I/II, Beclin-1, p62 detected through western blot assay. Results results showed that resulted significant changes tissues, increased apoptosis, activated autophagy. Pretreatment significantly protects against by inhibiting Conclusion summary, our study confirmed autophagy activation.

Language: Английский

---

Electrophysiological differences of randomized deep sedation with dexmedetomidine versus propofol

BMC Anesthesiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 31, 2024

Abstract Background Dexmedetomidine and propofol are common sedatives in intensive care units for interventional procedures. Both may compromise sinus node function atrioventricular conduction. The objective of this prospective, randomized study is to compare the effect dexmedetomidine with on Methods In a tertiary center Switzerland we included from September 2019 October 2020 160 patients (65 ± 11 years old; 32% female) undergoing first ablation atrial fibrillation by cryoballoon or radiofrequency ablation. Patients were randomly assigned deep sedation (DEX group) versus (PRO group). A standard electrophysiological was performed after pulmonary vein isolation still deeply sedated hemodynamically stable. Results Eighty each DEX PRO group. group had higher baseline cycle length (1022 vs. 1138 ms; p = 0.003) longer recovery time (SNRT400; 1597 1412 0.042). However, both corrected SNRT normalized did not differ. PR interval (207 186 0.002) AH (111 95 ms, 0.008), Wenckebach (512 456 0.005), effective refractory period (390 344 0.009). QRS width HV different. An arrhythmia, mainly fibrillation, induced 33 during study, without differences among groups (20% 15%, 0.533). Conclusions has more pronounced slowing rate suprahissian AV conduction than propofol, but infrahissian ventricular repolarization. These need be taken into account when using these sedatives. Trial registration ClinicalTrials.gov number NCT03844841, 19/02/2019

Language: Английский

---

Dexmedetomidina en la sedación del paciente críticamente enfermo: ¿Cuál el la relación riesgobeneficio respecto de otros agentes?

Deleted Journal, Journal Year: 2024, Volume and Issue: 12(4)

Published: Dec. 26, 2024

La dexmedetomidina es un agonista altamente selectivo de los receptores α-2 adrenérgicos con efectos sedantes, ansiolíticos, simpaticolíticos y analgésicos. Se ha planteado que su interacción al nivel del sistema nervioso central puede tener efecto favorable sobre el delirium, la estructuración sueño reactividad estrés en pacientes críticamente enfermos ventilados mecánicamente. Sin embargo, hemodinámica desencadena bifásico hemodinámico queprovoca hipertensión transitoria, seguida bradicardia e hipotensión, por lo algunos autores consideran insegura. Diversos estudios primarios recientes metanálisis han conseguido resultados interesantes diversos desenlaces facilitan interpretación posible beneficio este agente comparación sedantes tradicionales como propofol o midazolam. Mejor aún, se descrito adicional electrofisiología cardíaca, podría beneficiarespecialmente a antecedentes arritmia cual disminuye riesgo morbilidad mortalidad atención crítica. Considerando relevancia tópico, objetivo esta revisión brindar acercamiento relación riesgo-beneficio sedación paciente enfermo, respecto otros agentes utilizados tradicionalmente base evidencia más reciente.

---

Is dexmedetomidine the Jack of all perioperative trades?

European Journal of Cardio-Thoracic Surgery, Journal Year: 2023, Volume and Issue: 63(4)

Published: April 1, 2023

Journal Article Is dexmedetomidine the Jack of all perioperative trades? Get access Christoph Zürn, Zürn Department Congenital Heart Defects and Paediatric Cardiology, University Center Freiburg-Bad Krozingen, Medical Center—University Freiburg, Faculty Medicine, Germany Corresponding author. heart defects Pediatric Centre Freiburg University, Germany. Tel: +49 76127043230; e-mail: [email protected] (C. Zürn). https://orcid.org/0000-0003-1762-2490 Search for other works by this author on: Oxford Academic PubMed Google Scholar Brigitte Stiller https://orcid.org/0000-0002-7657-4647 European Cardio-Thoracic Surgery, Volume 63, Issue 4, April 2023, ezad138, https://doi.org/10.1093/ejcts/ezad138 Published: 06 2023 history Received: 21 March Accepted: 05 Corrected typeset: 18

Language: Английский

---