Targeting Inflammation in Acne: Current Treatments and Future Prospects

American Journal of Clinical Dermatology, Journal Year: 2023, Volume and Issue: 24(5), P. 681 - 694

Published: June 16, 2023

Acne is a common, chronic inflammatory condition affecting millions of people worldwide, with significant negative impact on quality life and mental health. characterized by comedones, papules, pustules, nodulocystic lesions, long-lasting sequelae including scarring dyspigmentation, the latter which more common in skin color. The four main pillars acne pathophysiology include alteration sebum production concentration, hyperkeratinization follicular unit, Cutibacterium acnes strains, an immune response. Newer research has provided greater insight into these pathophysiologic categories. This understanding pathogenesis led to numerous new emerging treatment modalities. These modalities combinations existing treatments, repurposing agents historically used for other conditions, topical novel antibiotics, oral probiotics, various procedural devices. article will provide overview treatments their link our current improved pathogenesis.

Language: Английский

---

The Skin and Natural Cannabinoids–Topical and Transdermal Applications

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 1049 - 1049

Published: July 24, 2023

The chemical constituents of the

Language: Английский

---

Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids

Cosmetics, Journal Year: 2024, Volume and Issue: 11(1), P. 22 - 22

Published: Feb. 6, 2024

Acne vulgaris is a prevalent dermatological disorder that impacts the quality of life for millions people around world. The multifactorial nature this requires innovative and effective treatment strategies. Over time, there has been growing interest regarding use natural topical therapies, with cannabinoids emerging as promising group compounds investigation. In context acne treatment, are particular due to their anti-acne properties, namely, lipostatic, anti-inflammatory, antiproliferative, antimicrobial activities. Among these bioactive compounds, cannabidiol stands out notable derivative, exhibiting spectrum therapeutic actions. Pre-clinical clinical studies have proven its ability modulate sebum production, reduce inflammation, inhibit bacterial proliferation—all which critical components in pathogenesis dermatosis. This review provides comprehensive overview cannabinoids’ potential novel holistic approach summarizes recent developments area.

Language: Английский

---

Harnessing Cannabis sativa Oil for Enhanced Skin Wound Healing: The Role of Reactive Oxygen Species Regulation

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1277 - 1277

Published: Sept. 30, 2024

emerges as a noteworthy candidate for its medicinal potential, particularly in wound healing. This review article explores the efficacy of cannabis oil reducing reactive oxygen species (ROS) during healing acute and chronic wounds, comparing it to standard treatments. ROS, produced from various internal external sources, play crucial role development by causing cell tissue damage. Understanding ROS on skin wounds is essential, they act both signaling molecules contributors oxidative Cannabis oil, recognized antioxidant properties, may help mitigate damage scavenging upregulating antioxidative mechanisms, potentially enhancing emphasizes ongoing research future potential dermatological treatments, highlighted through clinical studies patent updates. Despite promising benefits, optimizing formulations therapeutic applications remains challenge, underscoring need further realize capabilities wounds.

Language: Английский

---

Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids

Published: Jan. 18, 2024

Acne vulgaris is a prevalent dermatological disorder that impacts the quality of life for millions people around world. The multifactorial nature this requires innovative and effective treatment strategies. Over time, there has been growing interest regarding use natural topical therapies, with cannabinoids emerging as promising group compounds investiga-tion. In context acne treatment, are particular due to their anti-acne properties, namely, lipostatic, anti-inflammatory, antiproliferative, antimicrobial activities. Among these bioactive compounds, cannabidiol stands out notable derivative, exhibiting spectrum therapeutic actions. Pre-clinical clinical studies have proven its ability modulate sebum production, reduce inflammation, inhibit bacterial proliferation - all which critical components in pathogenesis dermatosis. This review provides comprehen-sive overview cannabinoids' potential novel holistic approach summarizes recent developments area.

Language: Английский

---

Cannabis-Based Phytocannabinoids: Overview, Mechanism of Action, Therapeutic Application, Production, and Affecting Environmental Factors

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11258 - 11258

Published: Oct. 19, 2024

This review provides an overview of cannabis-based phytocannabinoids, focusing on their mechanisms action, therapeutic applications, and production processes, along with the environmental factors that affect quality efficacy. Phytocannabinoids such as THC (∆9-tetrahydrocannabinol), CBD (cannabidiol), CBG (cannabigerol), CBN (cannabinol), CBC (cannabichromene) exhibit significant potential in treating various physical mental health conditions, including chronic pain, epilepsy, neurodegenerative diseases, skin disorders, anxiety. The cultivation cannabis plays a crucial role determining cannabinoid profiles, indoor offering more control consistency than outdoor methods. Environmental light, water, temperature, humidity, nutrient management, CO2, drying method used are key to optimizing content inflorescences. outlines need for broader data transfer between industry technological production, especially terms what concentration ratios effective treatment. Such would provide cultivators information parameters should be manipulated obtain required final product.

Language: Английский

---

Cannabis as a Source of Approved Drugs: A New Look at an Old Problem

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7686 - 7686

Published: Nov. 21, 2023

Cannabis plants have been used in medicine since ancient times. They are well known for their anti-diabetic, anti-inflammatory, neuroprotective, anti-cancer, anti-oxidative, anti-microbial, anti-viral, and anti-fungal activities. A growing body of evidence indicates that targeting the endocannabinoid system various other receptors with cannabinoid compounds holds great promise addressing multiple medical conditions. There two distinct avenues development cannabinoid-based drugs. The first involves creating treatments directly based on components cannabis plant. second a singular molecule strategy, which specific phytocannabinoids or newly discovered cannabinoids therapeutic pinpointed synthesized future pharmaceutical validation. Although potential is enormous, few cannabis-related approved drugs exist, this avenue warrants further investigation. With mind, we review here medicinal properties cannabis, its phytochemicals, natural synthetic origin, pitfalls way to widespread clinical use additional applications products.

Language: Английский

---

Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1 - 15

Published: Jan. 1, 2025

Objective: The aim of this study is to investigate the protective effect Cannabidiol (CBD) on DSS-induced colitis in C57BL/6 mice and its related pathways. Methods: A mouse model ulcerative (US) was induced by DSS. Enzyme-linked immunosorbent assay (ELISA), quantitative reverse transcription polymerase-chain reaction (qRT-PCR), Western blot (WB) immunofluorescence (IF) were used identify key factors involved inflammatory response, oxidative stress intestinal fibrosis. In addition, we transfected si-RNA into CCD-18Co cells. Results: research suggests that CBD significantly improves inflammation up-regulating nuclear factor erythroid 2-related 2 (Nrf2) expression, inhibiting classical Nuclear Factor kappa-light-chain-enhancer activated B cells (NF-κb) pathway, release IL-6 (Interleukin), IL-1β, Tumor Necrosis Factor-α (TNF-α) other factors. At same time, plays an antioxidant role regulating Nrf2/ HO-1 (Heme Oxygenase-1) pathway activating activity. On hand, may regulate Transforming growth beta (TGF-β)/SMADs signaling expression TGF-β 1, thereby α-SMA, Collagen1, TIMP1 factors, thus playing anti-fibrotic role. Notably, when Nrf2 inhibited or lacking, loses above against colon injury. Conclusion: affects NF-κb Heme Oxygenase-1 (HO-1) (TGF-β)/SMAD Nrf2, reducing colonic improving progression Keywords: Ulcerative colitis, cannabidiol, fibrosis,

Language: Английский

---

The therapeutic effect of cannabidiol in oral mucosa lesions

Brazilian journal of oral sciences/Brazilian Journal of Oral Sciences, Journal Year: 2025, Volume and Issue: 24, P. e255518 - e255518

Published: March 28, 2025

Aim: This study aims to analyze the potential therapeutic effect of cannabidiol use on oral mucosa lesions in clinical and vivo studies. Methods: A scoping review was conducted considering question: “Is there a (CBD) mucosa?”. Four distinct databases were searched (PubMed/MEDLINE, Embase, Web Science, Scopus) gray literature until August 2023. Original studies included, involving human animal subjects where CBD applied topically or administered systemically for treatment superficial/deep alterations mucosa. Results: total 610 records found initial searches. Twelve assessed full text eligibility five excluded. Seven included this review. Five with design only two had humans. Considering results from studies, all them presented better lesion groups treated CBD-based therapy compared placebo. Regarding histological features, four statistically significant improvement one did not find improvement. For positive (primarily regarding pain control) therapies. Conclusion: appears effective treating (oral mucositis, ulcers, burning mouth syndrome). therapies can reduce inflammation hold promise control healing However, limited number trials, heterogeneity cannabis-based therapies, lack standardized protocols underscore need further rigorous, interdisciplinary research establish consistent dosing assess efficacy various cannabinoids conditions.

Language: Английский

---

Cannabidiol Inhibits Inflammation Induced by Cutibacterium acnes-Derived Extracellular Vesicles via Activation of CB2 Receptor in Keratinocytes

Journal of Inflammation Research, Journal Year: 2022, Volume and Issue: Volume 15, P. 4573 - 4583

Published: Aug. 1, 2022

Acne is a common inflammatory skin disease, while cannabidiol (CBD) representative non-psychoactive phytocannabinoid which has been proved to exert universal anti-inflammatory properties. This study aimed explore the effect of CBD on acne inflammation induced by Cutibacterium acnes-derived extracellular vesicles (CEVs) in keratinocytes and reveal underlying mechanisms.Normal human epidermal (NHEKs) were stimulated CEVs presence or vehicle. Interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α levels examined RT-PCR ELISA. The expression cannabinoid type-2 (CB2) receptor transient potential vanilloid type-1 (TRPV1) was detected Western blotting. TNF-α CB2 antagonist (AM630) TRPV1 (Capsazepine) RT-PCR. activation MAPK NF-κB signaling pathways nuclear translocation p65 upon treatment analyzed blotting immunofluorescence assay, respectively.The cytokines (IL-6, IL-8 TNF-α) CEVs-stimulated NHEKs suppressed CBD. upregulated CBD, whereas CEVs-promoted downregulated AM630 reversed inhibited Capsazepine exerted an inhibitory CEVs-induced had synergistic with phosphorylation ERK1/2 but reduced CBD.The results indicated that could inhibit NHEKs, mediated enhanced antagonist, through inactivation pathways. might be novel strategy for future.

Language: Английский

---