Regulation of mitochondrial autophagy by lncRNA MALAT1 in sepsis-induced myocardial injury DOI Creative Commons

Guangqing Huang,

Xu Zhao, Yong Bai

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 1, 2024

Sepsis-induced myocardial injury (SIMI) is a severe complication of sepsis, contributing significantly to mortality. Mitochondrial dysfunction and dysregulated autophagy are implicated in SIMI pathogenesis. Long non-coding RNA MALAT1 has been associated with various diseases, including but its role remains unclear.

Language: Английский

The lactate to albumin ratio linked to all-cause mortality in critically ill patients with septic myocardial injury DOI Creative Commons
Sheng Chen,

Senhong Guan,

Zhaohan Yan

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 13, 2023

The lactate to albumin ratio (LAR) has emerged as a promising prognostic marker in critically ill patients. Despite its potential utility, the value of LAR septic myocardial injury (SMI) remains uncertain.This study aims investigate significance SMI through retrospective cohort analysis data from Medical Information Mart for Intensive Care III (MIMIC-III) (v1.4) database. included intensive care unit (ICU)-admitted patients (age ≥18 years) diagnosed with SMI. primary endpoint was in-hospital mortality.A total 704 were study, which 59.10% male. Hospital mortality and ICU rates recorded at 29.97% 22.87%, respectively. After adjusting confounding factors, multivariate Cox proportional risk demonstrated that independently associated an increased both hospital (HR, 1.39 [95% CI: 1.24-1.56] P < 0.001) 1.46 1.29-1.65] 0.001). Furthermore, generalized additive model (GAM) restricted cubic spline (RCS) indicated linear relationship between hospital.The may serve biomarker High levels are higher can help identify individuals high rates. Overall, findings emphasize importance using tool stratification management

Language: Английский

Citations

6
E3 ubiquitin ligase COP1-mediated CEBPB ubiquitination regulates the inflammatory response of macrophages in sepsis-induced myocardial injury DOI

Yangzi Yu,

Qiang Fu, Jiarui Li

et al.

Mammalian Genome, Journal Year: 2023, Volume and Issue: 35(1), P. 56 - 67

Published: Nov. 18, 2023

Language: Английский

Citations

6
Epigallocatechin-3-gallate protects sepsis‐induced myocardial dysfunction by inhibiting the nuclear factor-κB signaling pathway DOI Creative Commons
Bei Chen, Yafei Li, Fang Zhang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27163 - e27163

Published: Feb. 27, 2024

Sepsis-induced myocardial dysfunction (SIMD) has become one of the most lethal complications sepsis, while treatment was limited by a shortage pertinent drugs. Epigallocatechin-3-gallate (EGCG) is highest content active substances in green tea, and its application cardiovascular diseases broad prospects. This study conducted to test hypothesis that EGCG able inhibit lipopolysaccharide (LPS) induced investigate underlying molecular mechanisms. The cardiac systolic function assessed echocardiography. cardiomyocyte apoptosis determined TUNEL staining. expression inflammatory factors apoptosis-related protein, markers were examined Western Blot qRT-PCR. effectively improve LPS-induced damage, enhance left ventricular function, restore cell vitality. It can upregulation TLR4 LPS IκB α/NF- κB/p65 signaling pathway, thereby inhibiting improving myocarditis. In conclusion, protects against SIMD through anti-inflammatory anti-apoptosis effects; it mediated inhibition TLR4/NF-κB signal pathway. Our results demonstrated might be possible medicine for prevention treatment.

Language: Английский

Citations

2
PTX3 mediates PI3K/AKT/mTOR signaling to downregulate apoptosis and autophagy to attenuate myocardial injury in sepsis DOI Creative Commons
Na Cui, Zhi Chen,

Zhanbiao Yu

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17263 - e17263

Published: May 20, 2024

This study aimed to investigate the effect and mechanism of Pentraxin 3 (PTX3) on myocardial injury in sepsis.

Language: Английский

Citations

2
Regulation of mitochondrial autophagy by lncRNA MALAT1 in sepsis-induced myocardial injury DOI Creative Commons

Guangqing Huang,

Xu Zhao, Yong Bai

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 1, 2024

Sepsis-induced myocardial injury (SIMI) is a severe complication of sepsis, contributing significantly to mortality. Mitochondrial dysfunction and dysregulated autophagy are implicated in SIMI pathogenesis. Long non-coding RNA MALAT1 has been associated with various diseases, including but its role remains unclear.

Language: Английский

Citations

2