Clinical significance of lactate-to-albumin ratio in patients with influenza A virus-induced acute respiratory distress syndrome: a single-center retrospective study DOI Creative Commons

Jinhui Gao,

Xuekang Yang, Xiangming Fang

et al.

BMC Anesthesiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

The lactate-to-albumin ratio (LAR) is predictive of disease prognosis in some cases. However, the clinical significance LAR patients with influenza A virus-induced acute respiratory distress syndrome (ARDS) has yet to be explored. This study aims investigate whether can used as a predictor ARDS. In this single-center retrospective study, we enrolled 105 virus pneumonia into and divided an ARDS group (74 patients) non-ARDS (31 during hospitalization. Clinical characteristics laboratory data were collected within 24 h after admission. We explored risk factors for using logistic regression analysis. performance potential ARDS-associated complications evaluated by receiver operating characteristic (ROC) curves, Pearson's correlation analysis was evaluate correlations between variables. independent development significantly LAR's area under curve (AUC) higher than that lactate albumin alone; its AUC 0.878, sensitivity 71.6% specificity 96.8%. optimal ROC threshold distinguishing from cases 44.81 × 10− 3. Correlation indicated positively associated duration invasive ventilation, APACHE II SOFA scores but negatively PaO2/FiO2 (p < 0.001). Subsequent determined robust 14-day ventilation (AUC = 0.924), septic shock 0.860), hepatic injury 0.905) hospitalized patients. It also showed promising value 28-day mortality 0.881). strongly predicted pneumonia. significant severity provided efficiency extrapulmonary

Language: Английский

Association between lactate/albumin ratio and prognosis in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy DOI Creative Commons
Jianfei Liu, Jie Min, Jianhong Lu

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(2)

Published: July 5, 2024

Background The primary objective was to examine the association between lactate/albumin ratio (LAR) and prognosis of patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT).

Language: Английский

Citations

6
Assessing the Predictive Impact of Preoperative Lactate Dehydrogenase to Albumin Ratio on Outcomes Following Coronary Artery Bypass Graft Surgery DOI Open Access
Özgür Barış, Canbolat Mert Holat, Mahya Sultan Tosun

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 554 - 554

Published: Jan. 16, 2025

Background: The lactate dehydrogenase to albumin ratio (LAR) is a novel inflammatory marker and potential predictor of mortality in various conditions. No research has yet examined LAR's impact on cardiac surgery patients. This study evaluated role predicting complications isolated coronary artery bypass grafting (CABG) Methods: A retrospective analysis 377 CABG patients (93 women, 24.7%; 284 men, 75.3%; mean age 65.9 years) from 2020 2024 was conducted. Data included demographics, preoperative characteristics, surgical details, postoperative outcomes, along with ICU hospital length stay (LOS). Results: In-hospital 6.1% (n = 23). Independent predictors were low ejection fraction (EF) (OR: 0.96, p 0.024), baseline LAR 1.08, 0.000), LOS-ICU 1.1, ventricular tachycardia 37.9, 0.006), acute renal failure 12.1, 0.000). Mortality cases had higher median than survivors (8.6 vs. 5.2, Elevated correlated lower EF (r -0.227, longer 0.17, 0.001), LOS-hospital 0.208, cut-off 7.097 predicted (AUC: 0.823, sensitivity 78.3%, specificity 77.1%). values observed all groups (p < 0.05), indicating its consistent association negative outcomes. Conclusions: valuable in-hospital associated ICU/hospital stays poorer Preoperative assessment can guide risk stratification, forecast mortality, inform planning treatment strategies.

Language: Английский

Citations

0
Association between the lactate-to-albumin ratio (LAR) index and risk of acute kidney injury in critically ill patients with sepsis: analysis of the MIMIC-IV database DOI Creative Commons
Yi‐Ming Hua, Ning Ding, Haoyu Jing

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

Lactate-to-albumin ratio (LAR) is an emergency predictive indicator of sepsis-related mortality. An elevated LAR associated with poor outcomes in critically ill patients. However, its value for acute kidney injury (AKI) patients sepsis remains unclear. Therefore, this study aimed to investigate the relationship between and AKI sepsis. The population was derived from Medical Information Mart Intensive Care-IV (2.0) database stratified into quartiles based on LAR. primary endpoint occurrence AKI. secondary endpoints were use renal replacement therapy (RRT) in-hospital Kaplan-Meier survival analysis Cox proportional hazards models used assess association index risk In study, 5,222 included, whom 3,029 male (58%). demonstrated significant differences cumulative incidence usage rate RRT among index. Additionally, adjusted confounding factors showed a Our indicated that high can serve as independent predictor

Language: Английский

Citations

0
Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study DOI Creative Commons

Huizhen Tang,

Mingli Qu,

Miaomiao Xin

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 24, 2025

The aim of this study was to investigate the correlation between lactate-albumin ratio (LAR) and 28-day mortality in patients with sepsis combined acute kidney failure (SA-AKI). based on eICU database collected data from 1855 SA-AKI. relationship LAR in-hospital assessed using multivariate Cox regression models Kaplan-Meier survival analysis. A generalised summation model also used analyse non-linear mortality. results showed that rate 19.46% (361/1,855), a significant positive (HR: 1.26, 95% CI: 1.18–1.35, p < 0.001). curve highest quartile (Q4) had lowest rate. Non-linear analysis when less than 2.1, increased each 1-unit increase ratio, an adjusted hazard 1.48 (95% CI 1.20, 1.84, For SA-AKI, nonlinear risk death observed, higher associated

Language: Английский

Citations

0
Association between lactate to albumin ratio and mortality among sepsis associated acute kidney injury patients DOI Creative Commons

Yaotang Wang,

Haixia Yu

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 26, 2025

Sepsis-Associated Acute Kidney Injury (SA-AKI) has high fatality rates, but clear outcome markers are lacking. The objective of this research was to ascertain the link between lactate-to-albumin ratio (LAR) and mortality in cases SA-AKI. We performed a retrospective cohort analysis 3589 critically ill patients with SA-AKI using Intensive Care Medical Information Mart IV (MIMIC-IV) database. Patients were categorized into four groups based on quartiles LAR. findings study provide baseline data outcomes regarding in-hospital, 30-day, 90-day rates for intensive care unit. utilized multivariate cox regression compute adjusted hazard (HR) 95% confidence intervals (95% CI). Subgroup restricted cubic spline curves employed further investigate relationship LAR mortality. This involved participants mean age 62.5 years. group Q4 (LAR ≥ 0.95) associated an increased risk in-hospital mortality, 30-day (hazards (HR): 2.11, CI:1.7–2.62; HR: 1.9, CI: 1.55–2.34; 1.91, 1.58–2.31, respectively). Notably, within subgroup AKI stages 2 no CHF patients, association more pronounced. underscores that elevated linked heightened risks. analyses have demonstrated correlation is particularly robust certain patient cohorts, most notably those stage without congestive heart failure (CHF). Not applicable.

Language: Английский

Citations

0
Clinical significance of lactate-to-albumin ratio in patients with influenza A virus-induced acute respiratory distress syndrome: a single-center retrospective study DOI Creative Commons

Jinhui Gao,

Xuekang Yang, Xiangming Fang

et al.

BMC Anesthesiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

The lactate-to-albumin ratio (LAR) is predictive of disease prognosis in some cases. However, the clinical significance LAR patients with influenza A virus-induced acute respiratory distress syndrome (ARDS) has yet to be explored. This study aims investigate whether can used as a predictor ARDS. In this single-center retrospective study, we enrolled 105 virus pneumonia into and divided an ARDS group (74 patients) non-ARDS (31 during hospitalization. Clinical characteristics laboratory data were collected within 24 h after admission. We explored risk factors for using logistic regression analysis. performance potential ARDS-associated complications evaluated by receiver operating characteristic (ROC) curves, Pearson's correlation analysis was evaluate correlations between variables. independent development significantly LAR's area under curve (AUC) higher than that lactate albumin alone; its AUC 0.878, sensitivity 71.6% specificity 96.8%. optimal ROC threshold distinguishing from cases 44.81 × 10− 3. Correlation indicated positively associated duration invasive ventilation, APACHE II SOFA scores but negatively PaO2/FiO2 (p < 0.001). Subsequent determined robust 14-day ventilation (AUC = 0.924), septic shock 0.860), hepatic injury 0.905) hospitalized patients. It also showed promising value 28-day mortality 0.881). strongly predicted pneumonia. significant severity provided efficiency extrapulmonary

Language: Английский

Citations

0