Association between 91 circulating inflammatory proteins and the risk of glaucoma: A Mendelian randomization study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 14, 2025

Glaucoma is a leading cause of irreversible blindness worldwide, with its pathogenesis incompletely understood. Inflammation, as an important aspect glaucoma, has attracted increasing attention. In this study, we performed Mendelian randomization (MR) analysis to investigate the association between 91 circulating inflammatory proteins and glaucoma. First, bidirectional MR was employed screen for that potentially influence glaucoma risk, findings further confirmed by replication sample MR. Then, mediation assess mediating effects endophenotypes on Finally, subgroup subtypes, including primary open-angle (POAG) angle-closure (PACG). The suggested 7 out were possibly related T-cell surface glycoprotein CD5 (CD5) (odds ratio (OR) = 0.87; 95% confidence interval (CI): 0.81–0.94; P 2.46 × 10−4) passing false discovery rate correction. This result verified revealed intraocular pressure (IOP) (β=-0.05; CI: −0.02-−0.09; 1.56 10−3) mediator CD5's protective effect indicated conferred causal specifically POAG, not PACG. Moreover, IOP served in explaining proportion 38.29% against POAG. Our suggest negative POAG which partially mediated IOP. indicates targeted therapy may be beneficial eyes.

Language: Английский

Neutrophils in Ocular Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7736 - 7736

Published: July 15, 2024

Neutrophils, traditionally viewed as first responders to infection or tissue damage, exhibit dynamic and diverse roles in ocular health disease. This review elaborates on previous findings that showed how neutrophils contribute diseases. In infections, play a pivotal role host defense by orchestrating inflammatory responses combat pathogens. Furthermore, optic nerve neuropathies retinal degenerative diseases like age-related macular degeneration (AMD) diabetic retinopathy (DR), are implicated neuroinflammation damage owing their ability undergo neutrophil extracellular trap formation (NETosis) secretion of molecules. Targeting neutrophil-dependent processes holds promise therapeutic strategy, offering potential avenues for intervention cancers, Understanding the multifaceted is crucial developing targeted therapies improve patient outcomes.

Language: Английский

A neural network model for predicting the effectiveness of treatment in patients with neovascular glaucoma associated with diabetes mellitus

Romanian Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: 68(3)

Published: Oct. 7, 2024

The study hypothesizes that neural networks can be an effective tool for predicting treatment outcomes in patients with diabetic neovascular glaucoma (NVG), considering not only baseline intraocular pressure (IOP) values but also inflammation and microcirculation indicators.

Language: Английский