Blood cytokines as potential predictors of the development of SARS-CoV-2 associated pneumonia in patients with stage II ESSENTIAL hypertension DOI Creative Commons
О. А. Радаева, А. С. Симбирцев, M. S. Iskandyarova

et al.

Russian Journal of Infection and Immunity, Journal Year: 2024, Volume and Issue: 14(3), P. 437 - 442

Published: July 28, 2024

The search for predictors of the severe course COVID-19 was relevant both during pandemic and at present time. aim study to analyze relationship cytokine levels in patients with EН before SARS-CoV-2 infection incidence coronavirus pneumonia. Materials methods. From database 290 stage II EAG who have been under observation 8–12 years annual blood sampling determine levels, survivors were selected (mild without pneumonia moderate severe, CT 1–2, CT-3). Anamnestic IL-1β, IL-1α, IL-1ra, IL-18, IL-18 BP, IL-37, IL-6, sIL-6r, M-CSF, VEGF-A, IL-34 HMGB1) serum EH analyzed (method ELISA). analysis obtained results carried out using Stat Soft Statistica 13.5. Results discussion. Patients (CT I-II) after 2–6 months infectious disease had significantly higher levels: IL-1α (p 0.05) a decrease IL-37 0.001). During multivariate correlation analysis, statistically independent between an increase viral confirmed only level less than 60.2 pg/ml (regression coefficient — 2.21, standard error 0.28, t criterion 6.12, relative risk 2.52, Walda 7.92, p = 0.006). When studying circadian rhythms content groups, calculating strength correlations anamnestic evening EР 19.00–20.00 frequency against background infection, it has greater specificity sensitivity (specificity 0.75, 0.82) morning concentrations. Considering that data on limited number patients, further monitoring is necessary, which by our scientific group. It should be noted essential hypertension are pathogenetically heterogeneous, including terms regulation. this area will make possible personalize phenotypes develop new methods prognosis cardiovascular complications features diseases.

Language: Английский

ANXA3 as a novel biomarker for sepsis diagnosis: evidence from integrative WGCNA analysis DOI Creative Commons
Jingxiang Zhang,

Xin-Hao Xing,

Ren-Yi Lu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38608 - e38608

Published: Sept. 30, 2024

Language: Английский

Citations

2
Low-dose pro-resolving mediators temporally reset the resolution response to microbial inflammation DOI Creative Commons
Charles N. Serhan, Nan Chiang, Robert Nshimiyimana

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Sept. 18, 2024

Specialized pro-resolving mediators (SPMs) promote resolution of inflammation, clear infections and stimulate tissue regeneration. These include resolvins, protectins, maresins. During self-resolving acute SPMs are produced have key functions activating endogenous response for returning to homeostasis. Herein, we addressed whether initiated with ongoing inflammation alter programs, if low-dose repetitive SPM regimen re-programs the response.

Language: Английский

Citations

1
Bioinformatics and molecular biology tools for diagnosis, prevention, treatment and prognosis of COVID-19 DOI Creative Commons
Débora Dummer Meira, Aléxia Stefani Siqueira Zetum, Matheus Correia Casotti

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34393 - e34393

Published: July 1, 2024

Since December 2019, a new form of Severe Acute Respiratory Syndrome (SARS) has emerged worldwide, caused by SARS coronavirus 2 (SARS-CoV-2). This disease was called COVID-19 and declared pandemic the World Health Organization in March 2020. Symptoms can vary from common cold to severe pneumonia, hypoxemia, respiratory distress, death. During this period world stress, medical scientific community were able acquire information generate data at unprecedented speed, better understand facilitate vaccines therapeutics development. Notably, bioinformatics tools instrumental decoding viral genome identifying critical targets for diagnosis therapeutics. Through integration omics data, also improved our understanding pathogenesis virus-host interactions, facilitating development targeted treatments vaccines. Furthermore, molecular biology techniques have accelerated design sensitive diagnostic tests characterization immune responses, paving way precision medicine approaches treating COVID-19. Our analysis highlights indispensable contributions global effort against In review, we aim revise features, diagnostic, prevention, treatment options, how biology, modern bioinformatic tools, collaborations helped combat pandemic. An integrative literature review performed, searching articles on several sites, including PUBMED Google Scholar indexed referenced databases, prioritizing last 3 years. The lessons learned will place much position respond future pandemics.

Language: Английский

Citations

0
Blood cytokines as potential predictors of the development of SARS-CoV-2 associated pneumonia in patients with stage II ESSENTIAL hypertension DOI Creative Commons
О. А. Радаева, А. С. Симбирцев, M. S. Iskandyarova

et al.

Russian Journal of Infection and Immunity, Journal Year: 2024, Volume and Issue: 14(3), P. 437 - 442

Published: July 28, 2024

The search for predictors of the severe course COVID-19 was relevant both during pandemic and at present time. aim study to analyze relationship cytokine levels in patients with EН before SARS-CoV-2 infection incidence coronavirus pneumonia. Materials methods. From database 290 stage II EAG who have been under observation 8–12 years annual blood sampling determine levels, survivors were selected (mild without pneumonia moderate severe, CT 1–2, CT-3). Anamnestic IL-1β, IL-1α, IL-1ra, IL-18, IL-18 BP, IL-37, IL-6, sIL-6r, M-CSF, VEGF-A, IL-34 HMGB1) serum EH analyzed (method ELISA). analysis obtained results carried out using Stat Soft Statistica 13.5. Results discussion. Patients (CT I-II) after 2–6 months infectious disease had significantly higher levels: IL-1α (p 0.05) a decrease IL-37 0.001). During multivariate correlation analysis, statistically independent between an increase viral confirmed only level less than 60.2 pg/ml (regression coefficient — 2.21, standard error 0.28, t criterion 6.12, relative risk 2.52, Walda 7.92, p = 0.006). When studying circadian rhythms content groups, calculating strength correlations anamnestic evening EР 19.00–20.00 frequency against background infection, it has greater specificity sensitivity (specificity 0.75, 0.82) morning concentrations. Considering that data on limited number patients, further monitoring is necessary, which by our scientific group. It should be noted essential hypertension are pathogenetically heterogeneous, including terms regulation. this area will make possible personalize phenotypes develop new methods prognosis cardiovascular complications features diseases.

Language: Английский

Citations

0