Immunomodulatory effects and clinical application of exosomes derived from mesenchymal stem cells DOI

Yangfei Yi,

Z FAN,

Can Liu

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 19, 2025

Exosomes (Exos) are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication. They play a pivotal role in the pathogenesis progression various diseases offer promising avenues for therapeutic interventions. Exos derived from mesenchymal stem (MSCs) have significant immunomodulatory properties. effectively regulate immune responses modulating both innate adaptive immunity. These can inhibit excessive inflammatory promote tissue repair. Moreover, they participate antigen presentation, which is essential activating responses. The cargo these Exos, including ligands, proteins, microRNAs, suppress T cell activity or enhance population immunosuppressive to dampen response. By inhibiting lymphocyte proliferation, acting on macrophages, increasing regulatory cells, contribute maintaining metabolic homeostasis. Furthermore, activate immune-related signaling pathways vehicles deliver microRNAs other bioactive substances target tumor holds potential immunotherapy applications. Given immense MSC-derived this review comprehensively explores their mechanisms regulation applications areas such infection control, suppression, autoimmune disease management. This article aims provide valuable insights into behind actions offering theoretical references future clinical utilization cell-free drug preparations.

Language: Английский

Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research DOI Creative Commons
Ziqian Li, Junyu Yan, Xiang Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 19, 2025

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in field of biosciences for their role intercellular communication various physiological and pathological processes. Their ubiquitous presence bodily fluids cell-specific characteristics make them promising candidates as biomarkers. Additionally, ability to transport biological therapeutics across different barriers specific target underscores significant translational potential diagnostic therapeutic purposes. Significant progress has been achieved translation EVs research clinical applications, however, challenges persist large-scale production EVs, particularly areas scalable manufacturing, efficient isolation methods, drug loading techniques, advanced characterization technology. This review critically examines complex processes involved biogenesis explores recent developments production. By synthesizing knowledge from these fields, this aims provide a holistic perspective on evolving landscape its underscoring both accomplishments obstacles that lie ahead fully realizing biomedicine.

Language: Английский

Citations

1
Immunomodulatory effects and clinical application of exosomes derived from mesenchymal stem cells DOI

Yangfei Yi,

Z FAN,

Can Liu

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 19, 2025

Exosomes (Exos) are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication. They play a pivotal role in the pathogenesis progression various diseases offer promising avenues for therapeutic interventions. Exos derived from mesenchymal stem (MSCs) have significant immunomodulatory properties. effectively regulate immune responses modulating both innate adaptive immunity. These can inhibit excessive inflammatory promote tissue repair. Moreover, they participate antigen presentation, which is essential activating responses. The cargo these Exos, including ligands, proteins, microRNAs, suppress T cell activity or enhance population immunosuppressive to dampen response. By inhibiting lymphocyte proliferation, acting on macrophages, increasing regulatory cells, contribute maintaining metabolic homeostasis. Furthermore, activate immune-related signaling pathways vehicles deliver microRNAs other bioactive substances target tumor holds potential immunotherapy applications. Given immense MSC-derived this review comprehensively explores their mechanisms regulation applications areas such infection control, suppression, autoimmune disease management. This article aims provide valuable insights into behind actions offering theoretical references future clinical utilization cell-free drug preparations.

Language: Английский

Citations

0