Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1 DOI Creative Commons

Radwa H. Lutfy,

Amina E. Essawy, Haitham S. Mohammed

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 49(4), P. 919 - 934

Published: Dec. 20, 2023

The growing prevalence of aged sleep-deprived nations is turning into a pandemic state. Acute sleep deprivation (SD) accompanies aging, changing the hippocampal cellular pattern, neurogenesis pathway expression, and aggravating cognitive deterioration. present study investigated ability Near Infra Red (NIR) light laser to ameliorate impairment induced by SD in young senile rats. Wistar rats ≤ 2 months (young) ≥ 14 (senile) were for 72 h with or without transcranial administration NIR 830 nm. Our results showed that photobiomodulation (PBM) attenuated deterioration made young, but not rats, while both exhibited decreased anxiety (mania)-like behavior response PBM. PBM had an inhibitory effect on AChE, enhanced production ACh, ROS, regulated cell apoptosis factors such as Bax Bcl-2. increased mRNA expression BDNF GLP-1 thus facilitating neuronal survival differentiation. findings also revealed age exerts additive factor assaults produced where damages 2-month less severe than those one. In conclusion, seems promote longevity cells combating elevating neurotrophic factors, improving performance. provide possible candidate insults accompanying aging SD.

Language: Английский

Multifunctional Photonic Nanomaterials and Devices for Digital Photomedicine via Neuro‐Immune Cross‐Talks DOI
Seong‐Jong Kim, Tae‐Yeon Kim,

H. Kim

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract The nervous and immune systems are closely interconnected, influence the onset progress of various diseases. Accordingly, understanding interaction neural system becomes very important for treatment intractable diseases with analysis therapeutic mechanisms, such as autoimmune diseases, neurodegenerative cancers, so on. conventional immunomodulation treatments have been mainly carried out by drug administration, but they suffered from systemic negative side‐effects only limited effects on specific disease. In this Perspective, photonic nanomaterials devices reviewed discussed digitally controlled neurostimulating photomedicine via photobiomodulation optogenetics unique viewpoint neuro‐immune cross‐talks. prospects perspectives to integrate advanced wearable implantable healthcare also provided highlighted revolutionize strategies systems, optimize protocols futuristic digital photomedicine. This approach will fields neurostimulation regulation further clinical applications.

Language: Английский

Citations

2

Integrative Interventions for Improving Outcomes in Depression: A Narrative Review DOI Creative Commons
Matthew Halma,

Christof Plothe,

Paul E. Marik

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(2), P. 550 - 577

Published: April 29, 2024

Antidepressants are among the most used medications in US, with significant deleterious effects on people’s well-being. At any given time, depression impacts approximately 1 10 Americans, causing wide and broad societal costs. Interest is developing for non-pharmacological treatments preventative measures. We summarize literature non-invasive dietary lifestyle approaches treating depression. This review aims to inform future research treatment programs by providing an evidentiary summary of integrative therapeutic

Language: Английский

Citations

2

Dosimetry and Clinical Efficacy of Transcranial Photobiomodulation for Major Depression Disorder: Could they Guide Dosimetry for Alzheimer’s Disease? DOI
Marco Antônio Caldieraro,

Tatiana Laufer-Silva,

Paolo Cassano

et al.

Journal of Alzheimer s Disease, Journal Year: 2021, Volume and Issue: 83(4), P. 1453 - 1469

Published: Sept. 3, 2021

Background: Major depressive disorder (MDD) is prevalent and has significant impact on individuals society. Cognitive symptoms are frequent in MDD insufficiently treated by antidepressant medications. Transcranial photobiomodulation (t-PBM) a novel device therapy which shows promise as an pro-cognitive treatment. To date, despite the encouraging results, optimal stimulation parameters of t-PBM to treat not established, clinical studies very heterogeneous terms these parameters. While literature provides guidance appropriate fluence achieve therapeutic little known other Objective: evaluate relationship between different effect t-PBM. Methods: We reviewed comorbid with diseases. calculated standardized size change severity before after we performed descriptive analysis papers. Results: The greatest sizes for were found using pulse-wave high peak irradiance (but low average irradiance) over large skin surface. One well-designed sufficiently powered, double-blind, sham-controlled trial indicated that small surface ineffective depression. Conclusion: use Alzheimer’s disease dementia still at its inception; dosimetry lessons from depression might serve guidance.

Language: Английский

Citations

12

A Review of Applications and Intracellular Mechanisms of Intense Pulsed Light in Eyelid Inflammatory Diseases DOI

Hongya Zeng,

Lan Gong

Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2023, Volume and Issue: 41(3), P. 104 - 119

Published: March 1, 2023

Objective: To evaluate relevant clinical outcomes and conclude possible mechanisms of intense pulsed light (IPL) in eyelid inflammation. Background: IPL devices were primarily applied cutaneous vascular malformations have been used ocular diseases for about 20 years, mostly including meibomian gland dysfunction (MGD), blepharitis, rosacea. Recent findings: Seventy-two original researches included, 57 MGD, 4 blepharitis or blepharitis-related keratoconjunctivitis, 11 Dry eye symptoms, (tear) break-up time (BUT), structure and/or functions improved most patients, but production reactive oxygen species is an important link the photobiomodulation mediated by IPL, which can influence numerous signal pathways to achieve anti-inflammatory, anti-infective, prodifferentiation effects. Conclusions: The evidence suggests that effective therapeutic tool patients with more needed other indications.

Language: Английский

Citations

5

Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1 DOI Creative Commons

Radwa H. Lutfy,

Amina E. Essawy, Haitham S. Mohammed

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 49(4), P. 919 - 934

Published: Dec. 20, 2023

The growing prevalence of aged sleep-deprived nations is turning into a pandemic state. Acute sleep deprivation (SD) accompanies aging, changing the hippocampal cellular pattern, neurogenesis pathway expression, and aggravating cognitive deterioration. present study investigated ability Near Infra Red (NIR) light laser to ameliorate impairment induced by SD in young senile rats. Wistar rats ≤ 2 months (young) ≥ 14 (senile) were for 72 h with or without transcranial administration NIR 830 nm. Our results showed that photobiomodulation (PBM) attenuated deterioration made young, but not rats, while both exhibited decreased anxiety (mania)-like behavior response PBM. PBM had an inhibitory effect on AChE, enhanced production ACh, ROS, regulated cell apoptosis factors such as Bax Bcl-2. increased mRNA expression BDNF GLP-1 thus facilitating neuronal survival differentiation. findings also revealed age exerts additive factor assaults produced where damages 2-month less severe than those one. In conclusion, seems promote longevity cells combating elevating neurotrophic factors, improving performance. provide possible candidate insults accompanying aging SD.

Language: Английский

Citations

5