Is there an association between retinal vein occlusion and cerebrovascular accident? A systematic review and meta-analysis

BMC Ophthalmology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 6, 2025

Retinal vein occlusion (RVO) is a significant retinal vascular disorder that has been hypothesized to increase the risk of cerebrovascular accidents (CVA). Given shared pathology between retina and cerebral circulation, understanding association RVO stroke incidence critical for early intervention management. This systematic review meta-analysis aim evaluate CVA, including ischemic hemorrhagic subtypes, in patients with RVO. study followed Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines was registered PROSPERO (CRD42024557820). A search PubMed, Cochrane Library, Scopus, Web Science, Embase conducted from inception February 2025. Studies assessing CVA post-RVO adult (≥ 18 years) were included. Two independent reviewers performed selection, data extraction, quality assessment using Risk Bias tool Non-Randomized studies (ROBINS-I) used observational cohort studies. Meta-analysis Comprehensive Meta-Analysis (CMA) software version 3.7, applying fixed-effects model low heterogeneity. Subgroup sensitivity analyses based on type (BRVO vs. CRVO) subtype (ischemic CVA). Publication bias evaluated Egger's test funnel plots. total 14 (n = 97,812 patients) The pooled event rate 37.5% (95% CI: 37.3%-37.8%), no heterogeneity (I2 0%, p 0.97). analysis showed both (37.8%; 95% 37.3%-38.3%) (32.7%; 32.3%-33.1%) occurred at similar rates across branch (BRVO) central (CRVO). mortality post-CVA 69.0% 68.4%-69.5%), highlighting severity outcomes this population. cardiovascular events, myocardial infarction, 15.7% 15.4%-16.0%), reinforcing need monitoring patients. deep thrombosis (DVT) relatively (0.05%) but still warrants clinical attention high-risk populations. minimal, as confirmed by (p > 0.24) plot symmetry. Sensitivity robustness estimates. provides strong evidence linking an increased mortality. high (37.5%) (69%), are crucial. Patients should undergo comprehensive evaluation, blood pressure control, lipid regulation, anticoagulation therapy when indicated. findings support multidisciplinary approach involving ophthalmologists, neurologists, cardiologists proactive prevention strategies Future research explore genetic predispositions, inflammatory markers, AI-based predictive models improve stratification intervention.

Language: Английский

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Do people with diabetes have a higher risk of developing postoperative endophthalmitis after cataract surgery? A systematic review and meta-analysis

Journal of Ophthalmic Inflammation and Infection, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

Abstract Purpose Postoperative endophthalmitis (POE) is a rare but severe complication of cataract surgery. While diabetes mellitus may increase the risk POE, relationship remains unclear. Methods A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, Scopus, Medline, Embase, Google Scholar searched for relevant studies up to September 10, 2024. The study included both randomized controlled trials observational that evaluated POE outcomes in surgery patients, comparing people with without diabetes. Random-effects models used calculate pooled odds ratios (OR) 95% confidence intervals (CI). Results Nine review, seven analyzed meta-analysis. on undergoing revealed higher incidence this group, ratio 1.174 (95% CI: 1.109 1.242; p = 0.000) an rate 0.261%, compared 0.242% Males had 1.634 times (p 0.048), while hypertension together increased by 3.961 < 0.001). Posterior capsule rupture (PCR) was associated significantly developing which also more common diabetes, OR 3.434 1.789 6.591; 0.0001). use postoperative intracameral topical antibiotics reduced (OR: 0.231; 0.00). Conclusions This shows have PCR those 3.434, respectively. administration reduces groups. Our highlights importance maintaining well-controlled blood sugar pressure before Additionally, extra caution should be taken during prevent PCR, appropriate antibiotic considered minimize POE.

Language: Английский

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Is Multiwavelength Photobiomodulation Effective and Safe for Age-Related Macular Degeneration? A Systematic Review and Meta-Analysis

Ophthalmology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

This systematic review and meta-analysis compares the complications effects of photobiomodulation (PBM) therapy with sham treatment in patients age-related macular degeneration (AMD). AMD is a leading cause visual impairment older adults, current treatments primarily focusing on symptom management. PBM emerging as potential intervention to improve clinical anatomical outcomes AMD, necessitating comparative analysis determine its efficacy safety. A search was conducted across PubMed/Medline, Google Scholar Cochrane Library from inception January 13, 2025. Randomised controlled trials (RCTs) meeting predefined inclusion criteria were selected. Meta-analysis employed random-effects models. The risk bias included studies assessed using tools. total six studies, comprising 360 477 eyes, focused for dry AMD. Five eligible meta-analysis. Best-corrected acuity (BCVA) showed no significant improvement (SMD − 0.30, 95% CI 0.85 0.26, p = 0.30), high heterogeneity (I2 83%). Macular drusen volume also change 0.08, 0.52 0.37, 0.74), moderate 48%). single study reported effect geographic atrophy 0.28, 1.26 0.71, 0.58). Central subfield thickness 0.11, 0.25 0.47, 0.58) microperimetry 0.02, 0.48 0.44, 0.94) changes. adverse events indicated statistically increase group within 6 months (RR 0.48, 0.29–0.82, 0.007), while overall non-significant 1.04, 0.51–2.12, 0.91, I2 78%). Qualitative suggested that might enhance quality life compared treatment. suggests that, date, there are benefits Further long-term needed establish relevance safety profile.

Language: Английский

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Is Selective Laser Trabeculoplasty Effective in Reducing Intraocular Pressure for Primary Angle-Closure Glaucoma? A Systematic Review and Meta-Analysis

Current Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 2, 2025

Primary angle-closure glaucoma (PACG) is a significant cause of blindness globally, particularly in Asian populations, where it accounts for 25% cases. Selective laser trabeculoplasty (SLT) has emerged as promising treatment PACG, but its efficacy varies across studies. This meta-analysis aims to evaluate the effectiveness SLT reducing intraocular pressure (IOP) and compare outcomes between PACG primary open-angle (POAG). A systematic search was conducted PubMed, Scopus, Medline, EMBASE up July 2024 using predefined criteria. Studies assessing patients with were included. Data extraction included study characteristics, parameters, outcomes, such mean post-intervention IOP reduction failure rates. Statistical analysis performed pooled estimates 95% confidence intervals (CI) through Comprehensive Meta-Analysis software. Of 754 potentially relevant articles assessed, 7 met inclusion The post-SLT among significantly decreased 17.30 mmHg (95% CI: 16.99-17.61; p = 0.0001). rate 7.95% 6.15-10.28%; 0.00001). reported varying trends medication use need further interventions patients. comprehensively examined treating multiple Despite variations sample sizes, demographics, locations, effectively reduced demonstrated statistically decrease IOP, highlighting therapeutic benefit despite notable heterogeneity

Language: Английский

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Is Botulinum toxin A effective in treating dry eye disease? A systematic review and meta-analysis

Eye, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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