Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose DOI Creative Commons
Takashi Maruyama, Hirofumi Miyazaki,

Yun-Ji Lim

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 6, 2023

Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse model. However, it is still less clear if affects tumor-induced immune suppression. In this study, we found that inhibited Treg generation the presence of transforming growth factor beta 1 (TGF-β). showed impact on Foxp3+ Tregs tumor microenvironment. Gastric cells produce large amount L-lactate and diminish inhibitory role against response to TGF-β. Therefore, naïve CD4+ T co-cultured with treated increased generation. GO-Y022-induced cell death was further enhanced by 2-deoxy-d-glucose (2DG), glycolysis inhibitor. Combination treatment 2DG results reduced production cells. Overall, GO-Y022-treatment restricted glucose metabolism inhibits survival promotes anti-tumor immunity.

Language: Английский

The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity DOI Creative Commons
Rodolfo Chavez-Dominguez,

Mario Perez-Medina,

José Sullivan López-González

et al.

Frontiers in Oncology, Journal Year: 2020, Volume and Issue: 10

Published: Oct. 7, 2020

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic stresses that challenge homeostasis growth. Cancer display activation distinct mechanisms for adaptation growth even in the presence stress. Autophagy is catabolic mechanism aides degradation damaged intracellular material metabolite recycling. This activity helps meet metabolic needs during nutrient deprivation, genotoxic stress, factor withdrawal hypoxia. However, autophagy plays paradoxical role depending on stage tumor development. Early suppressor via potentially oncogenic molecules. advanced stages, promotes survival by ameliorating stress microenvironment. These roles intricate due their interconnection with other cellular pathways. In this review, we present broad view participation phases Moreover, important processes such as cell death, reprogramming, metastasis, immune evasion treatment resistance all contribute development, reviewed. Finally, contribution hypoxic deficient microenvironment regulation these hallmarks development more aggressive tumors discussed.

Language: Английский

Citations

248
The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer DOI Creative Commons
Chang Liu, Ying Jin, Zhimin Fan

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: Sept. 3, 2021

Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to diversity, heterogeneity, adaptability environmental alters in clinic. To determine more possibilities for therapy, recent studies have begun explore changes metabolism, especially glycolysis. The Warburg effect is a hallmark that refers preference cells metabolize glucose anaerobically rather than aerobically, even under normoxia, which contributes chemoresistance. However, association between glycolysis molecular mechanisms glycolysis-induced unclear. This review describes mechanism from aspects process, signaling pathways, tumor microenvironment, their interactions. understanding how induces may provide new targets concepts therapy.

Language: Английский

Citations

138
Potential of Copper and Copper Compounds for Anticancer Applications DOI Creative Commons
Peng Ji, Peng Wang, Hao Chen

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 234 - 234

Published: Feb. 3, 2023

Inducing cancer cell death has always been a research hotspot in life sciences. With the continuous deepening and diversification of related research, potential value metal elements inducing explored. Taking iron as an example, ferroptosis, mainly characterized by increasing load driving production large amounts lipid peroxides eventually leading to death, recently attracted great interest community. After iron, copper, trace element, received extensive attention especially tumor death. Copper its complexes can induce autophagy or apoptosis cells through variety different mechanisms action (activation stress pathways, arrest cycle, inhibition angiogenesis, cuproptosis, paraptosis), which are promising therapy have become new hotspots treatment research. This article reviews main applications novel copper compound-induced focusing on compounds their anticancer applications.

Language: Английский

Citations

90
Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer DOI Creative Commons
Lin Zhao, Yuanyuan Liu,

Simiao Zhang

et al.

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(4)

Published: April 20, 2022

Metabolic disorders and abnormal immune function changes occur in tumor tissues cells to varying degrees. There is increasing evidence that reprogrammed energy metabolism contributes the development of suppressive microenvironment influences course gastric cancer (GC). Current studies have found (TME) also has important clinicopathological significance predicting prognosis therapeutic efficacy. Novel approaches targeting TME therapy, such as checkpoint blockade (ICB), metabolic inhibitors key enzymes metabolism, been involved treatment GC. However, interaction between GC how make better use these immunotherapy methods complex are still being explored. Here, we discuss reprogramming responses modulate anti-tumor responses, well effects gastrointestinal flora It proposed enhance response by understanding targeted provide direction for

Language: Английский

Citations

75
Identification of lysine-lactylated substrates in gastric cancer cells DOI Creative Commons
Dawei Yang, Jie Yin,

Liuqun Shan

et al.

iScience, Journal Year: 2022, Volume and Issue: 25(7), P. 104630 - 104630

Published: June 17, 2022

Cancer cells tend to utilize aerobic glycolysis generate energy and metabolites; the end product of is lactate, which promotes lysine lactylation (Kla). Kla a newly discovered histone post-translational modification (PTM) that plays important roles in regulating gene expression. However, non-histone mammalian proteins unclear. Here, comprehensive analysis lactylated gastric cancer AGS was conducted. There were 2375 sites found 1014 proteins. Interestingly, KEGG pathway showed these significantly enriched spliceosome function. In addition, more abundant tumors than adjacent tissues, high levels associated with poor prognosis. These results suggest could be prognostic marker cancer. This lactylome cells, first its kind, provides valuable foundation for further studies Kla.

Language: Английский

Citations

75
Lactic acid promotes macrophage polarization through MCT-HIF1α signaling in gastric cancer DOI
Lan Zhang, Shengmian Li

Experimental Cell Research, Journal Year: 2020, Volume and Issue: 388(2), P. 111846 - 111846

Published: Jan. 13, 2020

Language: Английский

Citations

116
Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway DOI Open Access
Yitian Dai, Yuping Liu, Jingyi Li

et al.

Bioengineered, Journal Year: 2022, Volume and Issue: 13(5), P. 13906 - 13918

Published: May 2, 2022

The active ingredient of the traditional Chinese medicine comfrey is shikonin, a naphthoquinone compound. focus this study was to investigate effect shikonin on proliferation, invasion, migration, and chemoresistance non-small cell lung cancer (NSCLC) cells, explore its underlying molecular biological mechanisms. results show that inhibited viability, migration NSCLC cells A549 PC9, induced apoptosis. As inhibitor pyruvate kinase M2 (PKM2), key enzyme in glycolysis, glucose uptake production lactate, final metabolite aerobic glycolysis. In vivo chemotherapeutic assay showed reduced tumor volume weight mice model increased sensitivity cisplatin chemotherapy. Histoimmunology experiments combination downregulated expression PKM2 transcriptionally regulated downstream gene transporter 1 (Glut1) tissue. an assessment metabolism, micro-PET/CT data fluorodeoxy (18F-FDG) into tumor. Since exosomal affected we also demonstrated could inhibit exosome secretion through administration GW4869. Furthermore, sensitized treatment by reducing extracellular PKM2. conclusion, suggest not only inhibits intracellularly but reduces glycolytic flux increases pathway.

Language: Английский

Citations

48
Ultra-sensitive and selective electrochemical biosensor with aptamer recognition surface based on polymer quantum dots and C60/MWCNTs- polyethylenimine nanocomposites for analysis of thrombin protein DOI

Hamid Reza Jamei,

Behzad Rezaei, Ali A. Ensafi

et al.

Bioelectrochemistry, Journal Year: 2020, Volume and Issue: 138, P. 107701 - 107701

Published: Nov. 19, 2020

Language: Английский

Citations

57
Melatonin: A Potential Therapeutic Option for Breast Cancer DOI
Xiangyi Kong, Ran Gao, Zhongzhao Wang

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2020, Volume and Issue: 31(11), P. 859 - 871

Published: Sept. 3, 2020

Language: Английский

Citations

55
Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries DOI Creative Commons
Anna Faivre, Thomas Verissimo,

Hannah Auwerx

et al.

Frontiers in Medicine, Journal Year: 2021, Volume and Issue: 8

Published: Oct. 29, 2021

Acute and chronic kidney disease are responsible for large healthcare costs worldwide. During injury, metabolism undergoes profound modifications in order to adapt oxygen nutrient shortage. Several studies highlighted recently the importance of these metabolic adaptations acute as well phases renal disease, with a potential deleterious effect on fibrosis progression. Until recently, glucose has been poorly studied, even though capacity use produce glucose, depending segment nephron. physiology, proximal tubular cells beta-oxidation fatty acid generate amounts energy, can also through gluconeogenesis. In undergo shift, shifting away from acids gluconeogenesis toward glycolysis. loss oxidation is well-described, data about emerging. We here review during their consequences, therapeutic implications.

Language: Английский

Citations

43