Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting DOI

Karin E. Sandoval,

K. Witt

Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 76(6), P. 1291 - 1325

Published: July 16, 2024

Over 4 decades of research support the link between Alzheimer disease (AD) and somatostatin [somatotropin-releasing inhibitory factor (SRIF)]. SRIF SRIF-expressing neurons play an essential role in brain function, modulating hippocampal activity memory formation. Loss rests at center a series interdependent pathological events driven by amyloid-β peptide (Aβ), culminating cognitive decline dementia. The connection AD further extends to neuropsychiatric symptoms, seizure activity, inflammation, whereas preclinical investigations show or receptor agonist administration capable enhancing cognition. subtype-4 activation particular presents unique attributes, with potential mitigate learning decline, reduce comorbid enhance enzymatic degradation Aβ brain. Here, we review links along therapeutic implications. SIGNIFICANCE STATEMENT: Somatostatin somatostatin-expressing are extensively involved contributing Targeting somatostatin-mediated processes has significant for treatment disease.

Language: Английский

Photobiomodulation in Alzheimer’s Disease—A Complementary Method to State-of-the-Art Pharmaceutical Formulations and Nanomedicine? DOI Creative Commons
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 916 - 916

Published: March 11, 2023

Alzheimer’s disease (AD), as a neurodegenerative disorder, usually develops slowly but gradually worsens. It accounts for approximately 70% of dementia cases worldwide, and is recognized by WHO public health priority. Being multifactorial disease, the origins AD are not satisfactorily understood. Despite huge medical expenditures attempts to discover new pharmaceuticals or nanomedicines in recent years, there no cure many successful treatments available. The current review supports introspection on latest scientific results from specialized literature regarding molecular cellular mechanisms brain photobiomodulation, complementary method with implications AD. State-of-the-art pharmaceutical formulations, development nanoscale materials, bionanoformulations applications perspectives highlighted. Another goal this was speed transition completely paradigms multi-target management AD, facilitate remodeling through therapeutic models high-tech light lasers integrative nanomedicine future. In conclusion, insights interdisciplinary approach, including photobiomodulation (PBM) applied human clinical trials, combined drug delivery systems easily overcome protective barriers, could open avenues rejuvenate our central nervous system, most fascinating complex organ. Picosecond transcranial laser stimulation be successfully used cross blood-brain barrier together nanotechnologies, therapy. Original, smart targeted multifunctional solutions nanodrugs may soon developed treat

Language: Английский

Citations

22
Current Findings and Potential Mechanisms of KarXT (Xanomeline–Trospium) in Schizophrenia Treatment DOI
Ali Azargoonjahromi

Clinical Drug Investigation, Journal Year: 2024, Volume and Issue: 44(7), P. 471 - 493

Published: June 21, 2024

Language: Английский

Citations

7
Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer’s Disease DOI Creative Commons
Галина Ф. Махаева, N. V. Kovaleva, Елена В. Рудакова

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 321 - 321

Published: Jan. 9, 2024

Effective therapeutics for Alzheimer's disease (AD) are in great demand worldwide. In our previous work, we responded to this need by synthesizing novel drug candidates consisting of 4-amino-2,3-polymethylenequinolines conjugated with butylated hydroxytoluene via fixed-length alkylimine or alkylamine linkers (spacers) and studying their bioactivities pertaining AD treatment. Here, report significant extensions these studies, including the use variable-length spacers more detailed biological characterizations. Conjugates were potent inhibitors acetylcholinesterase (AChE, most active was

Language: Английский

Citations

6
Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety DOI

Ayfer Kamalı,

Reşit Çakmak, Mehmet Boğa

et al.

Journal of the Chinese Chemical Society, Journal Year: 2022, Volume and Issue: 69(4), P. 731 - 743

Published: March 15, 2022

Abstract In this research, nine novel heterocyclic Schiff base derivatives ( 10–18 ) bearing an aryl sulfonate moiety were designed, synthesized for the first time, and characterized. Then, their inhibitory effects on acetyl‐ butyrylcholinesterase (AChE BChE) investigated in vitro conditions. Moreover, antioxidant activities examined by DPPH ABTS methods. The results indicated that some of tested molecules had varying enzyme inhibition activities. We determined compounds 8 , 9 14 17 18 with IC 50 values ranging from 89.30 to 111.28 μM against BChE, respectively compared standard compound galanthamine (IC = 125.88 μM). On other hand, tested, only 5 36.64 μM) displayed activity higher than AChE. assay, 15 161.93 μM), 16 191.76 107.55 showed BHT 203.50 it was assay bases 10 – (except BHT.

Language: Английский

Citations

24
Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer’s Disease: Recent Trends and Future Development DOI
Bhavarth P. Dave, Yesha Shah, Kunal G. Maheshwari

et al.

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(8), P. 3847 - 3884

Published: Sept. 19, 2023

Language: Английский

Citations

16
Hibiscus sabdariffa synthesized gold nanoparticles ameliorate aluminum chloride induced memory deficits through inhibition of COX-2/BACE-1 mRNA expression in rats DOI Creative Commons
Scholastica Onyebuchi Anadozie,

Duncan O. Effiom,

Olusola Bolaji Adewale

et al.

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(4), P. 104604 - 104604

Published: Jan. 23, 2023

Alzheimer's disease (AD) is a major health challenge worldwide, especially among the elderly. The associated with cognitive and memory deficits. This study investigated effect of Hibiscus sabdariffa synthesized-gold nanoparticles (HS-AuNPs) on AlCl3-induced deficits in rats. Forty-two male Wistar rats were divided into six groups (n = 7). Group I served as control. Rats group II - V exposed to AlCl3 (100 mg/kg) induce AD. III treated 5 mg/kg donepezil, 10 HS-AuNPs, respectively, for 14 days. Behavioral tests carried out day 28 42. At end animal experiment, sacrificed used various biochemical assays gene expression. AD showed learning impairment, these conditions ameliorated by HS-AuNPs. Significant (p < 0.05) elevation activities acetylcholinesterase, monoamine oxidase adenosine deaminase, well malondialdehyde levels was noted. A significant reduction superoxide dismutase (SOD), glutathione peroxidase (GPx) reduced (GSH) noted b.w. doses In addition, increased mRNA expression cyclooxygenase-2 (COX-2) beta-secretase 1 (BACE-1) caused assuaged HS-AuNPs treatment. Based against AD, could be considered potential therapeutic agent managing

Language: Английский

Citations

15
Combining Deep Learning and Structural Modeling to Identify Potential Acetylcholinesterase Inhibitors from Hericium erinaceus DOI Creative Commons
Thana Sutthibutpong,

Kewalin Posansee,

Monrudee Liangruksa

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(14), P. 16311 - 16321

Published: March 26, 2024

Alzheimer's disease (AD) is the most common type of dementia, affecting over 50 million people worldwide. Currently, approved medications for AD inhibit activity acetylcholinesterase (AChE), but these treatments often come with harmful side effects. There growing interest in use natural compounds prevention, alleviation, and treatment. This trend driven by anticipation that substances may incur fewer effects than existing medications. research presents a computational approach combining machine learning structural modeling to discover from medicinal mushrooms high potential AChE. First, we developed deep neural network capable rapidly screening vast number indicate their AChE activity. Subsequently, applied models screen BACMUSHBASE database, which catalogs bioactive cultivated wild mushroom varieties local Thailand, resulting identification five promising compounds. Next, identified underwent molecular docking techniques calculate binding energy between allowed us refine selection two compounds, erinacerin A hericenone B. Further analysis patterns target protein revealed both displayed profiles similar combined characteristics donepezil galanthamine, prescription drugs AD. We propose derived Hericium erinaceus (also known as lion's mane mushroom), are suitable candidates further development into symptom-alleviating

Language: Английский

Citations

5
Adverse event profile of memantine and donepezil combination therapy: a real-world pharmacovigilance analysis based on FDA adverse event reporting system (FAERS) data from 2004 to 2023 DOI Creative Commons
Yihan Yang, Sheng Wei, Huan Tian

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 17, 2024

Donepezil in combination with memantine is a widely used clinical therapy for moderate to severe dementia. However, real-world population data on the long-term safety of donepezil are incomplete and variable. Therefore, aim this study was analyze adverse events (AEs) according US Food Drug Administration Adverse Event Reporting System (FAERS) provide evidence monitoring therapy.

Language: Английский

Citations

5
Neuroprotective Potential of Origanum majorana L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model DOI Creative Commons
Ion Brinza, Răzvan Ştefan Boiangiu, Iasmina Honceriu

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 138 - 138

Published: Jan. 16, 2025

Origanum majorana L., also known as sweet marjoram, is a plant with multiple uses, both in the culinary field and traditional medicine, because of its major antioxidant, anti-inflammatory, antimicrobial, digestive properties. In this research, we focused on effects O. essential oil (OmEO, at concentrations 25, 150, 300 μL/L), evaluating chemical structure well impact cognitive performance oxidative stress, naive zebrafish (Danio rerio), scopolamine-induced amnesic model (SCOP, 100 μM). The fish behavior was analyzed novel tank-diving test (NTT), Y-maze test, object recognition (NOR) test. We investigated acetylcholinesterase (AChE) activity brain's stress status. parallel, performed silico predictions (research conducted using computational models) pharmacokinetic properties main compounds identified OmEO, platforms such SwissADME, pKCSM, ADMETlab 2.0, ProTox-II. results revealed that were trans-sabinene hydrate (36.11%), terpinen-4-ol (17.97%), linalyl acetate (9.18%), caryophyllene oxide (8.25%), α-terpineol (6.17%). OmEO can enhance memory through AChE inhibition, reduce SCOP-induced anxiety by increasing time spent top zone NTT, significantly markers. These findings underscore potential to improve impairment associated disorders, including Alzheimer's disease (AD).

Language: Английский

Citations

0
In Silico Study, Synthesis, and In Vitro Evaluation of Nicotinamide-Substituted 1,3,5-Triazine Derivatives as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase DOI
Tutumoni Kalita,

Shampa Dutta,

Anshul Shakya

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141577 - 141577

Published: Jan. 1, 2025

Language: Английский

Citations

0