International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 665, P. 124715 - 124715
Published: Sept. 14, 2024
Language: Английский
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24
Published: Jan. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Language: Английский
Citations
2
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159405 - 159405
Published: Jan. 1, 2025
Language: Английский
Citations
1
Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 1155 - 1163
Published: Jan. 1, 2025
Language: Английский
Citations
0
Laser & Photonics Review, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
Abstract Fluorescence molecular imaging (FMI), a promising in vivo non‐invasive optical technology, has high sensitivity, specificity, and spatio‐temporal resolution. Owing to its further advantages of low cost no radiation, FMI been extensively employed the diagnosis treatment tumors, vascular system, guided delivery drugs. Nonetheless, affected by strong photon absorption scattering, faces two major challenges: limited tissue penetration depth complicated tomography reconstruction. This review clarifies both challenges for first time summarizing advances near‐infrared region II (NIR‐II) fluorescence (FMT). In detail, NIR‐II conditions, representative probes, FMT systems, reconstruction algorithms are reviewed. The can achieve deeper higher resolution, which facilitate more accurate FMT. And turn, precise will promote development application imaging. Additionally, future deeply analyzed, potential improvement avenues discussed. strengthening methodological investigation is proposed impel FMI, ultimately providing effective tools biomedical field.
Language: Английский
Citations
0
Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 17, 2025
This review synthesizes experimental findings on various biomaterial scaffolds used in eyelid reconstruction. It examines the structural properties, cellular responses, and functional outcomes of such as chitosan, poly(propylene glycol fumarate)-2-hydroxyethyl methacrylate, fumarate) - type I collagen (PPF-Col), decellularized matrix-polycaprolactone, branched polyethylene, collagen, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate, poly(lactic-co-glycolic acid. These exhibit diverse mechanical biological with some demonstrating good biocompatibility, tunable potential for tissue repair. However, there are limitations, including concerns about long-term functionality a lack comprehensive evaluations. highlights need multifunctional that combine lid replacement ocular surface function restoration, well establishment standardized research methods. The goal is to guide future innovation field improve quality life patients defects.
Language: Английский
Citations
0
Nanomedicine, Journal Year: 2024, Volume and Issue: 19(16), P. 1471 - 1485
Published: July 2, 2024
Aim: This study focused on developing a topical gel incorporating lornoxicam-loaded poly(lactic-co-glycolic acid) and polyethylene glycol (PLGA-PEG) blend nanoparticles to mitigate gastrointestinal (GIT) side effects enhance therapeutic efficacy. Materials & methods: Synthesized were subjected in vitro characterization, ex vivo permeation studies, acute oral toxicity analysis post-incorporation into the using S/O/W double emulsion solvent. Results conclusion: The displayed smooth, spherical morphology (170–321 nm) with increased entrapment efficiency (96.2%). LOX exhibited rate of 70–94% from nanoparticle-infused gel, demonstrating favorable biocompatibility at cellular level. formulated enriched nanoparticles, holds promising prospects for drug-delivery systems improved outcomes LOX.
Language: Английский
Citations
2
International Urology and Nephrology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Language: Английский
Citations
2
Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 36(1)
Published: Dec. 26, 2024
ABSTRACT Numerous issues and concerns are associated with current cancer therapeutics, such as multidrug resistance tumors, drug toxicity, severe side effects, financial burden. Phytocompounds from plants have garnered significant interest alternatives adjunct therapies to mitigate these effects owing their safety, efficacy, cost‐effectiveness. As demonstrated by a number of preclinical clinical investigations, phytocompounds combinations doxorubicin mediate anticancer modulating multiple signaling pathways linked immune system mobilization, apoptosis promotion, inhibition excessive cellular proliferation. However, continue encounter challenges related inadequate bioavailability, pharmacokinetics, metabolism. To address challenges, the utilization different types nanoparticles has become in nanomedicine for targeted delivery, enhancing retention time, reducing toxicity. This field study showcases remarkable amalgamation nanotechnology chemo‐drugs (doxorubicin). Thus, this review focuses on recent developments nanocarriers based delivery systems, particularly those intended simultaneous chemotherapy medicines, synthesizing existing knowledge filling research gaps. also discussed combined therapy chemotherapeutic drugs other nanotechnology‐based carriers treatment.
Language: Английский
Citations
1
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 665, P. 124715 - 124715
Published: Sept. 14, 2024
Language: Английский
Citations
0