Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance DOI Creative Commons
Jing Cai, Fang Wang,

Shengjun Shi

et al.

The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 41(1)

Published: Dec. 11, 2024

The dysregulation of microRNA (miRNA) expression contributes to the development allergic rhinitis (AR). This study investigates serum miR-135a levels and their association with regulatory T cell (Treg) helper 17 (Th17) balance in AR patients. A total 93 patients 76 healthy controls were retrospectively recruited. Levels miR-135a, peripheral blood Th17 Treg cells, Treg/Th17-related cytokines measured. We assessed diagnostic value for its relationship Treg/Th17 balance. showed significantly elevated immunoglobulin E (IgE), IL-17 IL-6 levels, alongside reduced IL-10, TGF-β1, ratios. ≤0.536 demonstrated potential AR. Patients higher displayed increased level ratios, cell, lower nasal symptom score (TNSS). Serum negatively correlated TNSS, IL-17, IL-6, percentages, positively Collectively, decreased are associated balance, supporting as a biomarker diagnosis.

Language: Английский

Allergy Treatment: A Comprehensive Review of Nanoparticle-based Allergen Immunotherapy DOI Creative Commons
Mabrouk Abo-Zaid, Reem M. Elsapagh,

Nourhan S. Sultan

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 20, 2025

Allergic disorders rising in prevalence globally, affecting a substantial proportion of individuals industrialized nations. The imbalance the immune system, characterized by elevated allergen-specific T helper 2 (Th2) cells and immunoglobulin E (IgE) antibodies, is key factor allergy development. Allergen-specific immunotherapy (AIT) only treatment capable alleviating allergic symptoms, preventing new sensitizations, reducing asthma risk rhinitis patients. Traditional AIT, however, faces challenges such as frequent administration, adverse effects, inconsistent patient outcomes. Nanoparticle-based approaches have emerged promising strategy to enhance AIT. This review explores utilization nanoparticles highlighting their ability interact with system improve therapeutic Various types nanoparticles, including polyesters, polysaccharide polymers, liposomes, protamine-based (NPs), polyanhydrides, been employed adjuvants or carriers AIT’s efficacy safety. Nanoparticles offer advantages allergen protection, improved response modulation, targeted cell delivery, reduced side effects. provides an overview current landscape nanoparticle-based immunotherapy, discussing its potential revolutionize compared traditional immunotherapy.

Language: Английский

Citations

0
Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance DOI Creative Commons
Jing Cai, Fang Wang,

Shengjun Shi

et al.

The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 41(1)

Published: Dec. 11, 2024

The dysregulation of microRNA (miRNA) expression contributes to the development allergic rhinitis (AR). This study investigates serum miR-135a levels and their association with regulatory T cell (Treg) helper 17 (Th17) balance in AR patients. A total 93 patients 76 healthy controls were retrospectively recruited. Levels miR-135a, peripheral blood Th17 Treg cells, Treg/Th17-related cytokines measured. We assessed diagnostic value for its relationship Treg/Th17 balance. showed significantly elevated immunoglobulin E (IgE), IL-17 IL-6 levels, alongside reduced IL-10, TGF-β1, ratios. ≤0.536 demonstrated potential AR. Patients higher displayed increased level ratios, cell, lower nasal symptom score (TNSS). Serum negatively correlated TNSS, IL-17, IL-6, percentages, positively Collectively, decreased are associated balance, supporting as a biomarker diagnosis.

Language: Английский

Citations

1