Quantum Dot Nanomaterials: Empowering Advances in Optoelectronic Devices

Chemical Engineering Journal Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100704 - 100704

Published: Jan. 1, 2025

Language: Английский

---

Synthesis of AgInS2 quantum dots loaded with celastrol for induction of apoptosis and autophagy in hepatocellular carcinoma cells

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 16, 2025

Hepatocellular carcinoma (HCC) is a predominant form of liver cancer and one the leading causes cancer-related death globally. Therefore, there an urgent need for innovative therapeutic strategies that target molecular mechanisms underlying HCC progression metastasis, aiming to improve treatment efficacy patient survival. The natural product celastrol (Cel) has demonstrated inhibitory effects in various cell lines. However, its clinical application been hindered by high toxicity low safety threshold. Metal-free quantum dots (QDs), AgInS2 (AIS QDs) not only eliminate toxic risks associated with heavy metals but also exhibit biocompatibility biomedical field. By developing AIS QD@Cel, QDs nano-delivery system Cel, selectivity Cel on were enhanced. Fourier-transform infrared spectroscopy (FTIR) analysis revealed can interact via amide bonds. encapsulation rate reached 27.5%. QD@Cel eliminated 293T enhanced inhibition cells over 10 times. Furthermore, western blotting flow cytometry experiments showed promoted apoptosis autophagy signal pathway. Finally, transcriptome sequencing effect regulating gene expression involved critical signaling pathways are implicated cancer. This strategy holds potential increase threshold applicability offering significant value patients.

Language: Английский

---

Advances in Aptamer-Based Conjugate Recognition Techniques for the Detection of Small Molecules in Food

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1749 - 1749

Published: June 2, 2024

Small molecules are significant risk factors for causing food safety issues, posing serious threats to human health. Sensitive screening hazards is beneficial enhancing public security. However, traditional detection methods unable meet the requirements field of small molecules. Therefore, it necessary develop applicable with high levels sensitivity and specificity identify Aptamers short−chain nucleic acids that can specifically bind By utilizing aptamers enhance performance recognition technology, possible achieve selectivity when detecting There have been several varieties aptamer target techniques developed improve ability detect in recent years. This review focuses on principles platforms, classifies conjugating between aptamers, summarizes advancements aptamer−based conjugate food, seeks provide emerging powerful tools point−of−care diagnostics.

Language: Английский

---

Introduction to Special Issue “The Self-Assembly and Design of Polyfunctional Nanosystems 3.0”

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10966 - 10966

Published: Oct. 11, 2024

Stimulus-responsive systems allowing for the controlled release of drugs [...].

Language: Английский

---