Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review DOI Open Access

Evangelia Konstantinou,

Athanassios Panagiotopoulos,

Konstantina Argyri

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 2 - 2

Published: Dec. 19, 2023

Breast cancer is the most frequent type of in women. Oncogenic transcription factors promote overproduction cellular adhesion molecules and inflammatory cytokines during development. Cancer cells exhibit significant upregulation antiapoptotic proteins, resulting increased cell survival, tumor growth, metastasis. Research on cycle-mediated apoptosis pathway for drug discovery therapy has shown promising results. In fact, dietary phytoconstituents have been extensively researched anticancer activity, providing indirect protection by activating endogenous defense systems. The role polyphenols key signaling pathways could shed light underlying mechanisms action. For instance, Rosmarinic Acid, a polyphenol constituent many culinary herbs, potent chemoprotective properties. this review, we present recent progress investigation natural products as agents, with focus effect Acid triple-negative BC lines resistant to hormone therapy. We highlight variety integrated chemical biology approaches aimed at utilizing relevant action that lead clinical advances treatment.

Language: Английский

Molecular Pathways of Genistein Activity in Breast Cancer Cells DOI Open Access

Evangelia Konstantinou,

Aristea Gioxari,

Maria Dimitriou

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5556 - 5556

Published: May 20, 2024

The most common malignancy in women is breast cancer. During the development of cancer, oncogenic transcription factors facilitate overproduction inflammatory cytokines and cell adhesion molecules. Antiapoptotic proteins are markedly upregulated cancer cells, which promotes tumor development, metastasis, survival. Promising findings have been found studies on cycle-mediated apoptosis pathway for medication treatment. Dietary phytoconstituents studied great detail their potential to prevent by triggering body’s defense mechanisms. underlying mechanisms action may be clarified considering role polyphenols important signaling pathways. Phenolic acids, flavonoids, tannins, coumarins, lignans, lignins, naphthoquinones, anthraquinones, xanthones, stilbenes examples natural chemicals that being anticancer drugs. These substances also vital This review focuses innovations study polyphenol genistein’s effects cells presents integrated chemical biology methods harness therapeutic advances.

Language: Английский

Citations

22
Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review DOI Open Access

Evangelia Konstantinou,

Athanassios Panagiotopoulos,

Konstantina Argyri

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 2 - 2

Published: Dec. 19, 2023

Breast cancer is the most frequent type of in women. Oncogenic transcription factors promote overproduction cellular adhesion molecules and inflammatory cytokines during development. Cancer cells exhibit significant upregulation antiapoptotic proteins, resulting increased cell survival, tumor growth, metastasis. Research on cycle-mediated apoptosis pathway for drug discovery therapy has shown promising results. In fact, dietary phytoconstituents have been extensively researched anticancer activity, providing indirect protection by activating endogenous defense systems. The role polyphenols key signaling pathways could shed light underlying mechanisms action. For instance, Rosmarinic Acid, a polyphenol constituent many culinary herbs, potent chemoprotective properties. this review, we present recent progress investigation natural products as agents, with focus effect Acid triple-negative BC lines resistant to hormone therapy. We highlight variety integrated chemical biology approaches aimed at utilizing relevant action that lead clinical advances treatment.

Language: Английский

Citations

10