Celal Bayar Üniversitesi Fen Bilimleri Dergisi,
Journal Year:
2024,
Volume and Issue:
20(4), P. 116 - 122
Published: Dec. 9, 2024
Cancer
is
one
of
the
deadliest
diseases
worldwide,
and
for
this
reason,
it
a
prominent
field
study
in
drug
development.
It
has
been
reported
various
studies
that
some
plants
essential
oils
obtained
from
have
high
anticancer
activities.
This
situation
related
to
compound
groups
found
oils.
Studies
on
using
combination
with
synthetic
drugs
or
aromatherapy
are
ongoing.
Essential
show
cytotoxic
properties
may
play
role
death
cancer
cells.
Eugenol
an
important
clove,
laurel,
cinnamon
activity
types
cancer.
ability
reduce
cyclooxygenase-2
(COX-2)
inhibit
cell
proliferation
through
NF-κB
suppression
In
study,
binding
profiles
eugenol
COX-2
Human
inhibitor
nuclear
transcription
factor
κB
(IkB)
kinase
beta,
which
plays
crucial
signaling
pathway,
were
examined
by
molecular
docking
methods
used
computer-aided
design.
A
supporting
was
performed
understand
electrostatic
complementarity
between
ligand
receptor
potential
(MEP)
analysis.
As
result
comparatively
presented
similar
interaction
reference
compounds.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: April 17, 2025
Abstract
Although
cancer
chemopreventive
agents
have
been
confirmed
to
effectively
protect
high-risk
populations
from
invasion
or
recurrence,
only
over
ten
drugs
approved
by
the
U.S.
Food
and
Drug
Administration.
Therefore,
screening
potent
is
crucial
reduce
constantly
increasing
incidence
mortality
rate
of
cancer.
Considering
lengthy
prevention
process,
an
ideal
agent
should
be
nontoxic,
inexpensive,
oral.
Natural
compounds
become
a
natural
treasure
reservoir
for
chemoprevention
because
their
superior
ease
availability,
cost-effectiveness,
safety.
The
benefits
as
in
various
studies.
In
light
this,
present
review
intended
fully
delineate
entire
scope
chemoprevention,
primarily
focuses
on
aspects
based
compounds,
specifically
focusing
mechanism
action
prevention,
discussing
detail
how
they
exert
effects
affecting
classical
signaling
pathways,
immune
checkpoints,
gut
microbiome.
We
also
introduce
novel
strategies
summarize
role
improving
chemotherapy
regimens.
Furthermore,
we
describe
discovering
anticancer
with
low
abundance
high
activity,
revealing
broad
prospects
drug
discovery
chemoprevention.
Moreover,
associate
precision
medicine,
discuss
challenges
encountered
Finally,
emphasize
transformative
potential
advancing
field
ability
more
effective
less
toxic
preventive
options
oncology.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3741 - 3741
Published: Oct. 31, 2024
Conventional
cancer
treatments
include
surgical
resection,
chemotherapy,
hyperthermia,
immunotherapy,
hormone
therapy,
and
locally
targeted
therapies
such
as
radiation
therapy.
Standard
often
require
the
use
of
multiple
agents,
which
can
activate
nuclear
factor
kappa
B
(NF-κB)
in
tumor
cells,
leading
to
reduced
cell
death
increased
drug
resistance.
Moreover,
agents
also
contributes
added
toxicity,
resulting
poor
treatment
outcomes.
Cancer
cells
gradually
develop
resistance
almost
all
chemotherapeutics
through
various
mechanisms,
efflux,
alterations
metabolism
transport,
changes
signal
transduction
pathways,
enhanced
DNA
repair
capacity,
evasion
apoptosis,
mutations,
reactivation
targets,
interaction
with
microenvironment,
cell-stroma
interactions,
epithelial–mesenchymal
transition
(EMT)-mediated
chemoresistance,
epigenetic
modifications,
metabolic
alterations,
effect
stem
(CSCs).
Developing
new
strategies
improve
chemotherapy
sensitivity
while
minimizing
side
effects
is
essential
for
achieving
better
therapeutic
outcomes
enhancing
patients’
quality
life.
One
promising
approach
involves
combining
conventional
propolis
its
flavonoids.
These
natural
compounds
may
enhance
response
reducing
toxicity.
Propolis
components
sensitize
chemotherapeutic
likely
by
inhibiting
NF-κB
activation,
reprogramming
tumor-associated
macrophages
(TAMs;
an
M2-like
phenotype),
thereby
release
matrix
metalloproteinase
(MMP)-9,
cytokines,
chemokines,
vascular
endothelial
growth
(VEGF).
By
TAMs,
overcome
EMT-mediated
disrupt
crosstalk
between
CSCs,
inhibit
maintenance
stemness,
reverse
acquired
immunosuppression,
thus
promoting
antitumor
mediated
cytotoxic
T-cells.
This
review
highlights
potential
flavonoids
modulate
responsiveness
modalities.
The
evidence
suggests
that
novel
incorporating
could
be
developed
positive
cytotoxicity
peripheral
blood
leukocytes,
liver,
kidney
cells.
Therefore,
polyphenolic/flavonoid
hold
combination
clinical
types
cancers.
Plants,
Journal Year:
2025,
Volume and Issue:
14(1), P. 120 - 120
Published: Jan. 3, 2025
Valsa
mali
(V.
mali)
is
a
necrotrophic
fungus
responsible
for
apple
canker,
which
significantly
diminishes
production
yields
and
quality
in
China.
Our
serendipitous
findings
revealed
that
genistein
inhibits
the
mycelial
growth
of
V.
mali,
with
an
inhibition
rate
reaching
42.36
±
3.22%
at
concentration
10
µg/mL.
Scanning
electron
microscopy
analysis
caused
significant
changes
structure
including
contraction,
distortion,
deformity,
collapse,
irregular
protrusions.
Transmission
leakage
cellular
contents,
blurred
cell
walls,
ruptured
membranes,
organelle
abnormalities.
Genistein
has
been
shown
to
increase
reactive
oxygen
species
levels
mycelia,
as
demonstrated
by
2′,7′-dichlorofluorescin
diacetate
staining.
This
was
associated
decrease
superoxide
dismutase
activity
alongside
increases
catalase
peroxidase
activities.
These
collectively
disrupted
oxidative
equilibrium,
leading
induction
stress.
The
transcriptomic
13
genes
enriched
this
process,
linked
unsaturated
fatty
acid
biosynthesis
(three
downregulated
DEGs),
saturated
upregulated
six
metabolism
(four
nine
DEGs).
Additionally,
DEGs
VMIG_07417
VMIG_08675,
are
ergosterol
biosynthesis,
indicate
possible
membrane
composition.
In
conjunction
qRT-PCR
results,
it
hypothesized
exerts
antifungal
effect
on
through
ROS-mediated
lipid
peroxidation.
finding
potential
contribute
development
novel
biological
control
agents
industrial
crops.
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 31
Published: March 21, 2025
This
review
examines
recent
advancements
in
nanoparticle-based
delivery
systems
for
phytochemicals,
focusing
on
their
role
overcoming
multidrug
resistance,
improving
therapeutic
efficacy,
and
facilitating
clinical
translation.
highlights
advances
nanoparticle-enabled
phytochemical
to
enhance
bioavailability,
improve
outcomes,
enable
targeted
applications.
By
comparing
various
nanoparticle
systems,
formulation
methods,
efficacy
data,
it
identifies
gaps
current
research
guides
the
development
of
more
effective,
next-generation
phytochemical-loaded
nanocarriers.
A
systematic
literature
published
between
2000
2024
was
conducted
using
PubMed,
Scopus,
Web
Science.
Articles
cancer
therapy
were
included.
Compounds
such
as
curcumin,
resveratrol,
quercetin,
epigallocatechin
gallate
demonstrate
enhanced
anti-cancer
when
encapsulated
nanoparticles,
leading
improved
increased
tumor
cell
targeting,
reduced
toxicity.
Clinical
trials
indicate
regression
fewer
adverse
effects.
Emerging
approaches-such
nanogels,
hybrid
combination
therapies
with
immune
checkpoint
inhibitors-further
refine
treatment
efficacy.
Nanoparticle-based
significantly
potential
making
them
promising
candidates
safer,
effective
treatments.
However,
challenges
related
regulatory
guidelines,
scalability,
long-term
safety
must
be
addressed
fully
realize
potential.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2390 - 2390
Published: March 7, 2025
Cancer,
a
worldwide
problem
and
one
of
the
leading
causes
death
due
to
uncontrolled
cell
proliferation,
can
be
caused
by
various
factors,
such
as
genetic
environmental
factors.
Apoptosis
is
programmed
mechanism
that
eliminates
abnormal
cells
or
renews
cells.
There
are
two
main
apoptotic
pathways:
intrinsic
extrinsic
pathways.
These
pathways
affected
signaling
in
cancer,
PI3K/AKT,
MAPK,
Wnt,
JAK/STAT
Numerous
approaches
cancer
treatment
have
been
studied,
among
them,
natural
compounds
actively
researched.
Flavonoids
from
fruits
vegetables
studied
for
their
anti-cancer
effects.
Isoflavones,
subclasses
flavonoids,
usually
found
soy
food
legumes
effective
several
bioactive
functions.
The
well-known
isoflavones
genistein,
daidzein,
glycitein.
Irigenin
iridin
extracted
Iris
family.
Both
irigenin
currently
being
anti-inflammation,
antioxidant,
inducing
apoptosis.
In
this
review,
we
summarized
five
isoflavones,
glycitein,
irigenin,
effects
on
three
different
cancers:
breast
prostate
gastric
cancer.
