The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 8, 2023
Life
expectancy
is
increasing
throughout
the
world
and
coincides
with
a
rise
in
non-communicable
diseases
(NCDs),
especially
for
metabolic
disease
that
includes
diabetes
mellitus
(DM)
neurodegenerative
disorders.
The
debilitating
effects
of
disorders
influence
entire
body
significantly
affect
nervous
system
impacting
greater
than
one
billion
people
disability
peripheral
as
well
cognitive
loss,
now
seventh
leading
cause
death
worldwide.
Metabolic
disorders,
such
DM,
neurologic
remain
significant
challenge
treatment
care
individuals
since
present
therapies
may
limit
symptoms
but
do
not
halt
overall
progression.
These
clinical
challenges
to
address
interplay
between
warrant
innovative
strategies
can
focus
upon
underlying
mechanisms
aging-related
oxidative
stress,
cell
senescence,
death.
Programmed
pathways
involve
autophagy,
apoptosis,
ferroptosis,
pyroptosis
play
critical
role
oversee
processes
include
insulin
resistance,
β-cell
function,
mitochondrial
integrity,
reactive
oxygen
species
release,
inflammatory
activation.
silent
mating
type
information
regulation
2
homolog
1
Language: Английский
Cognitive Impairment in Multiple Sclerosis
Bioengineering,
Journal Year:
2023,
Volume and Issue:
10(7), P. 871 - 871
Published: July 23, 2023
Almost
three
million
individuals
suffer
from
multiple
sclerosis
(MS)
throughout
the
world,
a
demyelinating
disease
in
nervous
system
with
increased
prevalence
over
last
five
decades,
and
is
now
being
recognized
as
one
significant
etiology
of
cognitive
loss
dementia.
Presently,
modifying
therapies
can
limit
rate
relapse
potentially
reduce
brain
volume
patients
MS,
but
unfortunately
cannot
prevent
progression
or
onset
disability.
Innovative
strategies
are
therefore
required
to
address
areas
inflammation,
immune
cell
activation,
survival
that
involve
novel
pathways
programmed
death,
mammalian
forkhead
transcription
factors
(FoxOs),
mechanistic
target
rapamycin
(mTOR),
AMP
activated
protein
kinase
(AMPK),
silent
mating
type
information
regulation
2
homolog
1
(Saccharomyces
cerevisiae)
(SIRT1),
associated
apolipoprotein
E
(APOE-ε4)
gene
severe
acute
respiratory
syndrome
coronavirus
(SARS-CoV-2).
These
intertwined
at
levels
metabolic
oversight
cellular
metabolism
dependent
upon
nicotinamide
adenine
dinucleotide
(NAD+).
Insight
into
mechanisms
these
provide
new
avenues
discovery
for
therapeutic
treatment
dementia
cognition
occurs
during
MS.
Language: Английский
Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK
Cells,
Journal Year:
2023,
Volume and Issue:
12(22), P. 2595 - 2595
Published: Nov. 9, 2023
Metabolic
disorders
and
diabetes
(DM)
impact
more
than
five
hundred
million
individuals
throughout
the
world
are
insidious
in
onset,
chronic
nature,
yield
significant
disability
death.
Current
therapies
that
address
nutritional
status,
weight
management,
pharmacological
options
may
delay
but
cannot
alter
disease
course
or
functional
organ
loss,
such
as
dementia
degeneration
of
systemic
bodily
functions.
Underlying
these
challenges
onset
aging
associated
with
increased
lifespan,
telomere
dysfunction,
oxidative
stress
generation
lead
to
multi-system
dysfunction.
These
hurdles
point
urgent
need
underlying
mechanisms
innovative
applications.
New
treatment
strategies
involve
non-coding
RNA
pathways
microRNAs
(miRNAs)
circular
ribonucleic
acids
(circRNAs),
Wnt
signaling,
Wnt1
inducible
signaling
pathway
protein
1
(WISP1)
dependent
upon
programmed
cell
death
pathways,
cellular
metabolic
AMP-activated
kinase
(AMPK)
nicotinamide,
growth
factor
Non-coding
RNAs,
AMPK
cornerstone
for
overseeing
complex
offer
avenues
DM
will
necessitate
continued
appreciation
ability
each
independently
unison
influence
clinical
outcome.
Language: Английский