Curcumin, a component of golden spice: From bedside to bench and back

Biotechnology Advances, Journal Year: 2014, Volume and Issue: 32(6), P. 1053 - 1064

Published: April 30, 2014

Language: Английский

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Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review

Molecules, Journal Year: 2016, Volume and Issue: 21(3), P. 342 - 342

Published: March 11, 2016

Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, photosensitizer (PS) administered that can be activated by light of specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success PDT limited difficulty in administering photosensitizers (PSs) with low water solubility, compromises clinical use several molecules. Incorporation PSs nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid (SLNs), carriers (NLCs), gold (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, cyclodextrin potential strategy overcome this difficulty. Additionally, nanotechnology-based systems may improve transcytosis PS across epithelial endothelial barriers afford simultaneous co-delivery two or more drugs. Based on this, application nanotechnology medicine offer numerous exciting possibilities treatment efficacy available therapeutics. Therefore, aim paper review photodynamic cancer.

Language: Английский

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LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

Current Neuropharmacology, Journal Year: 2016, Volume and Issue: 14(2), P. 155 - 164

Published: Feb. 15, 2016

Neuroinflammation is an important feature in the pathogenesis and progression of neurodegenerative diseases such as Alzheimer´s disease (AD), Parkinson´s (PD), frontotemporal dementia amyotrophic lateral sclerosis. Based on current knowledge field, suggesting that targeting peripheral inflammation could be a promising additional treatment/prevention approach for diseases, drugs natural products with anti-inflammatory properties have been evaluated animal models neuroinflammation neurodegeneration. In this review, we provide extensive analysis one most widely-used peripherally induced neurodegeneration - lipopolysaccharide (LPS)-treated mice, address data reproducibility published research. We also summarize briefly basic features various products, nutraceuticals, known effects present overview their therapeutic potential reducing LPS-treated mice. Keywords: Astrocytes, LPS, microglia, neurodegeneration, neuroinflammation, nutraceuticals.

Language: Английский

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Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Journal of Alzheimer s Disease, Journal Year: 2018, Volume and Issue: 61(3), P. 843 - 866

Published: Jan. 9, 2018

The purpose of our article is to assess the current understanding Indian spice, curcumin, against amyloid-β (Aβ)-induced toxicity in Alzheimer’s disease (AD) pathogenesis. Natural products, such as ginger, and gingko biloba have been used diets dietary supplements treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes, neurological disorders. Products derived from plants are known protective effects, anti-inflammatory, antioxidant, anti-arthritis, pro-healing, boosting memory cognitive functions. In last decade, several groups designed synthesized curcumin its derivatives extensively tested using cell mouse models AD. Recent research on Aβ has revealed that prevents aggregation crosses blood-brain barrier, reach brain cells, protect neurons various toxic insults aging humans. also reported ameliorates decline improves synaptic functions Further, recent initiated studies elderly individuals patients with AD outcome these currently being assessed. This highlights beneficial effects critically assesses limitations curcumin’s bioavailability urgent need for new formulations increase levels

Language: Английский

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Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers

Journal of Food and Drug Analysis, Journal Year: 2017, Volume and Issue: 25(2), P. 219 - 234

Published: March 14, 2017

Chemical and enzymatic barriers in the gastrointestinal (GI) tract hamper oral delivery of many labile drugs. The GI epithelium also contributes to poor permeability for numerous Drugs with aqueous solubility have difficulty dissolving tract, resulting low bioavailability. Nanomedicine provides an opportunity improve efficiency orally administered Solid lipid nanoparticles (SLNs) are categorized as a new generation consisting complete solid matrix. SLNs used administration offer several benefits over conventional formulations, including increased solubility, enhanced stability, improved bioavailability, prolonged half-life, tissue targeting, minimal side effects. nontoxic excipients sophisticated material engineering tailor controllable physicochemical properties penetration via mucosal or lymphatic transport. In this review, we highlight recent progress development disease treatment. Recent application includes therapies cancers, central nervous system-related disorders, cardiovascular-related diseases, infection, diabetes, osteoporosis. addition drugs that may be active cargos SLNs, some natural compounds pharmacological activity suitable SLN encapsulation enhance article, systematically introduce concepts amelioration mechanisms nanomedical techniques drug- compound-loaded SLNs.

Language: Английский

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Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives

Materials Science and Engineering C, Journal Year: 2017, Volume and Issue: 77, P. 1316 - 1326

Published: March 27, 2017

Language: Английский

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Antiviral potential of curcumin

Journal of Functional Foods, Journal Year: 2017, Volume and Issue: 40, P. 692 - 699

Published: Dec. 22, 2017

Language: Английский

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Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability

Molecules, Journal Year: 2020, Volume and Issue: 25(12), P. 2791 - 2791

Published: June 17, 2020

Curcumin is a bioactive constituent isolated from turmeric that has historically been used as seasoning, pigment, and herbal medicine in food. Recently, it become one of the most commonly studied nutraceuticals pharmaceutical, supplement, food areas because its myriad potential health benefits. For instance, claimed to exhibit antioxidant, anti-inflammatory, antimicrobial, antiparasite, anticancer activities when ingested drug, or Toxicity studies suggest safe consume, even at relatively high levels. Its broad-spectrum biological low toxicity have meant widely explored nutraceutical ingredient for application functional foods. However, there are several hurdles formulators must overcome incorporating curcumin into commercial products, such water solubility (especially under acidic neutral conditions), chemical instability alkaline rapid metabolism by enzymes human body, limited bioavailability. As result, only small fraction actually absorbed bloodstream. These can be least partially using encapsulation technologies, which involve trapping within particles. Some edible microparticles nanoparticles utilized this purpose micelles, liposomes, emulsions, solid lipid particles, biopolymer Each these technologies own benefits limitations particular product applications important select appropriate one.

Language: Английский

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Recent advances in curcumin nanoformulation for cancer therapy

Expert Opinion on Drug Delivery, Journal Year: 2014, Volume and Issue: 11(8), P. 1183 - 1201

Published: May 24, 2014

Introduction: Natural compounds are emerging as effective agents for the treatment of malignant diseases. Curcumin (diferuloylmethane), active constituent turmeric extract, has gained significant interest a plant-based compound with anti-cancer properties. is physiologically very well tolerated, negligible systemic toxicity observed even after high oral doses administration. Despite curcumin's superior properties an agent its applications limited due to low solubility and physico-chemical stability, rapid clearance cellular uptake.Areas covered: This review focuses on development curcumin nano-particle formulation improve therapeutic index through enhanced uptake, localization targeted areas improved bioavailability. The feasibility nano-formulation in delivering limitations challenges designing administrating nano-sized particles also covered this review.Expert opinion: Nanotechnology promising tool enhance efficacy delivery drugs. In context, could reduce required dosages subsequently reduced cell toxicity. These nanoparticles capable provide local specific thereby preventing clearance. addition, using coating, better pharmacokinetic internalization nano-curcumin be achieved. However, potential nano-carriers important issue, which should taken into account nano-formulation.

Language: Английский

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Nutrition for the ageing brain: Towards evidence for an optimal diet

Ageing Research Reviews, Journal Year: 2016, Volume and Issue: 35, P. 222 - 240

Published: Oct. 7, 2016

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, indeed normal ageing remains however elusive. Considering limits existing preventive methods, there is a desire develop effective safe strategies. Growing preclinical clinical research in healthy individuals or at early stage cognitive decline has demonstrated beneficial impact nutrition on functions. present review most recent series produced by Nutrition Mental Performance Task Force under auspice International Life Sciences Institute Europe (ILSI Europe). latest scientific advances specific how dietary nutrients non-nutrient may affect are presented. Furthermore, several key points related mechanisms contributing ageing, pathological conditions affecting function, biomarkers also discussed. Overall, findings inconsistent fragmented more warranted determine establish dose-response relationships for optimal maintenance different population subgroups. Such approaches likely provide necessary evidence portfolios that will inform about new recommendations prevent decline.

Language: Английский

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