Biomedicines,
Journal Year:
2021,
Volume and Issue:
9(10), P. 1476 - 1476
Published: Oct. 14, 2021
Curcumin,
a
main
bioactive
component
of
the
Curcuma
longa
L.
rhizome,
is
phenolic
compound
that
exerts
wide
range
beneficial
effects,
acting
as
an
antimicrobial,
antioxidant,
anti-inflammatory
and
anticancer
agent.
This
review
summarizes
recent
data
on
curcumin’s
ability
to
interfere
with
multiple
cell
signaling
pathways
involved
in
cycle
regulation,
apoptosis
migration
several
cancer
types.
However,
although
curcumin
displays
potential,
its
clinical
application
limited
by
low
absorption,
rapid
metabolism
poor
bioavailability.
To
overcome
these
limitations,
curcumin-based
derivatives/analogues
different
drug
delivery
approaches
have
been
developed.
Here,
we
also
report
mechanisms
pharmacokinetic
characteristics
some
systems
used.
These
strategies,
encouraging,
require
additional
vivo
studies
support
applications.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(2), P. 135 - 135
Published: Jan. 20, 2022
Curcumin
(1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione)
is
a
natural
lipophilic
polyphenol
that
exhibits
significant
pharmacological
effects
in
vitro
and
vivo
through
various
mechanisms
of
action.
Numerous
studies
have
identified
characterised
the
pharmacokinetic,
pharmacodynamic,
clinical
properties
curcumin.
has
an
anti-inflammatory,
antioxidative,
antinociceptive,
antiparasitic,
antimalarial
effect,
it
used
as
wound-healing
agent.
However,
poor
curcumin
absorption
small
intestine,
fast
metabolism,
systemic
elimination
cause
bioavailability
human
beings.
In
order
to
overcome
these
problems,
number
formulations
been
developed.
The
aim
this
paper
provide
overview
recent
research
biological
pharmaceutical
aspects
curcumin,
methods
sample
preparation
for
its
isolation
(Soxhlet
extraction,
ultrasound
pressurised
fluid
microwave
enzyme-assisted
aided
extraction),
analytical
(FTIR,
NIR,
FT-Raman,
UV-VIS,
NMR,
XRD,
DSC,
TLC,
HPLC,
HPTLC,
LC-MS,
UPLC/Q-TOF-MS)
identification
quantification
different
matrices,
techniques
developing
formulations.
optimal
use
appropriate
method
will
significantly
improve
evaluation
activity
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(10), P. 1715 - 1715
Published: Oct. 17, 2021
Curcumin
possesses
a
plethora
of
interesting
pharmacological
effects.
Unfortunately,
it
is
also
characterized
by
problematic
drug
delivery
and
scarce
bioavailability,
representing
the
main
problem
related
to
use
this
compound.
Poor
absorption,
fast
metabolism,
rapid
systemic
clearance
are
most
important
factors
contributing
low
curcumin
levels
in
plasma
tissues.
Accordingly,
overcome
these
issues,
numerous
strategies
have
been
proposed
investigated
article.
Due
advances
field,
we
describe
here
promising
for
increasing
including
adjuvant,
complexed/encapsulated
curcumin,
specific
formulations,
nanoparticles.
We
analyze
current
strategies,
already
available
market,
advanced
technologies
that
can
offer
future
perspective
effective
formulations.
focus
attention
on
effectiveness
curcumin-based
formulations
clinical
trials,
providing
comprehensive
summary.
Clinical
trial
results,
employing
various
methods
showed
improved
bioavailability
corresponds
increased
therapeutic
efficacy.
Furthermore,
field
nanoparticles
hold
great
promise
developing
complexes
as
agents.
Summarizing,
suitable
polyphenol
will
ensure
possibility
using
curcumin-derived
practice
preventive
disease-modifying
therapeutics.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(23), P. 7109 - 7109
Published: Nov. 24, 2021
Curcumin
is
the
primary
polyphenol
in
turmeric's
curcuminoid
class.
It
has
a
wide
range
of
therapeutic
applications,
such
as
anti-inflammatory,
antioxidant,
antidiabetic,
hepatoprotective,
antibacterial,
and
anticancer
effects
against
various
cancers,
but
poor
solubility
low
bioavailability.
Objective:
To
improve
curcumin's
bioavailability,
plasma
concentration,
cellular
permeability
processes.
The
nanocurcumin
approach
over
curcumin
been
proven
appropriate
for
encapsulating
or
loading
(nanocurcumin)
to
increase
its
potential.
Conclusion:
Though
incorporating
into
form
may
be
viable
method
overcoming
intrinsic
limitations,
there
are
reasonable
concerns
regarding
toxicological
safety
once
it
enters
biological
pathways.
This
review
article
mainly
highlights
benefits
curcumin.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(12), P. 10713 - 10746
Published: March 13, 2023
Curcumin
has
been
credited
with
a
wide
spectrum
of
pharmacological
properties
for
the
prevention
and
treatment
several
chronic
diseases
such
as
arthritis,
autoimmune
diseases,
cancer,
cardiovascular
diabetes,
hemoglobinopathies,
hypertension,
infectious
inflammation,
metabolic
syndrome,
neurological
obesity,
skin
diseases.
However,
due
to
its
weak
solubility
bioavailability,
it
limited
potential
an
oral
medication.
Numerous
factors
including
low
water
solubility,
poor
intestinal
permeability,
instability
at
alkaline
pH,
fast
metabolism
contribute
curcumin's
bioavailability.
In
order
improve
different
formulation
techniques
coadministration
piperine,
incorporation
into
micelles,
micro/nanoemulsions,
nanoparticles,
liposomes,
solid
dispersions,
spray
drying,
noncovalent
complex
formation
galactomannosides
have
investigated
in
vitro
cell
culture
models,
vivo
animal
humans.
current
study,
we
extensively
reviewed
clinical
trials
on
various
generations
curcumin
formulations
their
safety
efficacy
many
We
also
summarized
dose,
duration,
mechanism
action
these
formulations.
critically
advantages
limitations
each
compared
placebo
and/or
available
standard
care
therapies
ailments.
The
highlighted
integrative
concept
embodied
development
next-generation
helps
minimize
bioavailability
issues
least
or
no
adverse
side
effects
provisional
new
dimensions
presented
this
direction
may
add
value
cure
Trends in Food Science & Technology,
Journal Year:
2022,
Volume and Issue:
120, P. 140 - 153
Published: Jan. 4, 2022
Over
the
last
three
decades,
consumption
of
total
and
saturated
fat
has
steadily
declined
in
Western
diets
as
a
proportion
calories
intake.
At
same
time,
omega
(ω)-6
fatty
acid
intake
risen
at
expense
ω-3
acids,
resulting
an
ω-6/ω-3
ratio
20:1
or
higher.
The
observed
changes
acids
coincide
with
significantly
increased
prevalence
coronary
heart
disease,
hypertension,
cancer,
diabetes,
obesity,
rheumatoid
arthritis,
autoimmune
neurodegenerative
disorders.
low
may
be
attributed
to
their
absence
from
diet
lack
awareness
about
suitable
dietary
sources.
A
sustainable
cost-effective
way
reaching
large
population
essential
is
fortification
staple
foods.
variety
food
items
enriched
have
entered
market
recent
years,
including
beef,
fish,
dairy
products,
cereals,
cereal
bars,
infant
formula.
present
review
discusses
role
ω-6
well
ratio,
on
human
health.
Additionally,
it
focuses
latest
developments
regarding
sources,
innovative
technologies,
challenges
acids.
Phytotherapy Research,
Journal Year:
2022,
Volume and Issue:
36(3), P. 1156 - 1181
Published: Feb. 7, 2022
Abstract
Curcumin
is
a
phytochemical
achieved
from
the
plant
turmeric.
It
extensively
utilized
for
treatment
of
several
types
diseases
such
as
cancers.
Nevertheless,
its
efficiency
has
been
limited
because
rapid
metabolism,
low
bioavailability,
poor
water
solubility,
and
systemic
elimination.
Scientists
have
tried
to
solve
these
problems
by
exploring
novel
drug
delivery
systems
lipid‐based
nanoparticles
(NPs)
(e.g.,
solid
lipid
NPs,
nanostructured
carriers,
liposomes),
polymeric
micelles,
nanogels,
cyclodextrin,
gold,
mesoporous
silica
NPs.
Among
these,
liposomes
most
expansively
studied.
This
review
mainly
focuses
on
different
curcumin
nanoformulations
their
use
in
cancer
therapy
vitro,
vivo,
clinical
studies.
Despite
development
curcumin‐containing
NPs
cancer,
potentially
serious
side
effects,
including
interactions
with
other
drugs,
some
toxicity
aspects
may
occur
that
require
more
high‐quality
investigations
firmly
establish
efficacy.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(16), P. 5236 - 5236
Published: Aug. 16, 2022
Throughout
the
United
States,
cancer
remains
second
leading
cause
of
death.
Traditional
treatments
induce
significant
medical
toxic
effects
and
unpleasant
adverse
reactions,
making
them
inappropriate
for
long-term
use.
Consequently,
anticancer-drug
resistance
relapse
are
frequent
in
certain
situations.
Thus,
there
is
an
urgent
necessity
to
find
effective
antitumor
medications
that
specific
have
few
consequences.
Curcumin
a
polyphenol
derivative
found
turmeric
plant
(Curcuma
longa
L.),
provides
chemopreventive,
antitumor,
chemo-,
radio-sensitizing
properties.
In
this
paper,
we
summarize
new
nano-based
formulations
polyphenolic
curcumin
because
growing
interest
its
application
against
cancers
tumors.
According
recent
studies,
use
nanoparticles
can
overcome
hydrophobic
nature
curcumin,
as
well
improving
stability
cellular
bioavailability
vitro
vivo.
Several
strategies
nanocurcumin
production
been
developed,
each
with
own
set
advantages
unique
features.
Because
majority
curcumin-based
nanoformulation
evidence
still
conceptual
stage,
numerous
issues
impeding
provision
possible
therapeutic
option.
To
support
science,
further
work
necessary
develop
viable
anti-cancer
adjuvant.
review,
cover
various
nanoformulations
implications
uses
cancer,
current
state
clinical
studies
patents.
We
address
knowledge
gaps
future
research
orientations
required
feasible
treatment
candidate.
Journal of Materials Science Materials in Medicine,
Journal Year:
2022,
Volume and Issue:
33(3)
Published: March 1, 2022
Abstract
Nanosponges
are
nanosized
drug
carriers
with
a
three-dimensional
structure
created
by
crosslinking
polymers.
They
have
the
advantage
of
being
able
to
hold
wide
range
drugs
various
sizes.
come
in
variety
shapes
and
distinguished
research
method
used,
type
polymer
they
may
contain.
superior
other
delivery
systems
because
can
provide
controlled
release
pattern
targeted
delivery.
The
period
action,
as
well
drug’s
residence
time,
be
regulated.
Since
it
is
made
biodegradable
materials,
has
low
toxicity
safe
use.
efficiency
encapsulation
determined
size
molecule
amount
void
space
available.
Cancer,
enzyme
biocatalyst
carrier,
oxygen
delivery,
solubility
enhancement,
immobilization,
poison
absorbent
some
applications
for
nanosponges.
preparation,
characterization,
factors
affecting
nanosponge
development,
loading
mechanism,
recent
developments
this
area,
patents
filed
area
nanosponges
all
highlighted
study.
International Journal of Biological Macromolecules,
Journal Year:
2023,
Volume and Issue:
232, P. 123283 - 123283
Published: Jan. 17, 2023
Hydrogels
have
emerged
as
a
versatile
platform
for
numerous
biomedical
application
due
to
their
ability
absorb
huge
quantity
of
biofluids.
In
order
design
hydrogels,
natural
polymers
are
an
attractive
option
owing
biocompatibility
and
biodegradability.
Due
abundance
in
occurrence,
cost
effectiveness,
facile
crosslinking
approaches,
alginate
has
been
extensively
investigated
fabricate
hydrogel
matrix.
Management
cancer
chronic
wounds
always
challenge
pharmaceutical
healthcare
sector.
both
cases,
curcumin
shown
significant
improvement
effectiveness.
However,
the
innate
restraints
like
poor
bioavailability,
hydrophobicity,
rapid
systemic
clearance
associated
with
restricted
its
clinical
translations.
The
current
review
explores
cascade
research
around
encapsulated
matrix
wound
healing
therapy.
focus
is
emphasize
mechanistic
effects
fate
inside
cells.
Further,
discusses
different
approaches
designed
loaded
hydrogels
along
parameters
that
regulates
release
behavior.
Finally,
concluded
on
some
key
aspect
increasing
efficacy
these
novel
strategies
further
develop
multifacet
applications.
