Prevalence and Predictors of Nonresponse to Psychological Treatment for PTSD: A Meta‐Analysis DOI Creative Commons
Verena Semmlinger, Cosima Leithner, Lea Maria Klöck

et al.

Depression and Anxiety, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Although highly efficacious psychological treatments for posttraumatic stress disorder (PTSD) exist, there is evidence that first-line treatment approaches leave a substantial subgroup of patients still suffering from clinically relevant PTSD symptoms posttreatment. We aimed to meta-analytically establish the prevalence and predictors nonresponse guideline-recommended PTSD. This meta-analysis was preregistered (CRD42023368766). searched Trials Standardized Data Repository, Embase, Medline, PsychINFO, PTSDpubs. included randomized controlled trials (RCT), reporting data on operationalized by (lack of) symptom reduction in at posttreatment adult meeting criteria diagnosis. All studies published October 10, 2023, were included. extracted two independent reviewers. estimated pooled average rates ORs. Subgroup metaregression analyses targeting served identify significant predictors. conducted using three-level multilevel models. Study quality assessed Cochrane's RoB 2 tool. Eighty six with 117 active conditions 7,894 participants meta-analysis. The weighted rate 39.23%, 95% CI (35.08%, 43.53%). Nonresponse less frequent condition compared control (OR = 0.22). revealed type analysis, population, intervention, format, year publication, age, sex, severity, comorbid depression, baseline depression score as heterogeneity between considerable (I 83.12%). Half had high risk bias. found showed after having received treatment. Treatment modifications should be considered specific subgroups based associated nonresponse.

Language: Английский

The Neuropsychology of Anxiety DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Language: Английский

Citations

73
Advances in the use of virtual reality to treat mental health conditions DOI
Imogen Bell, Roos Pot-Kolder, Albert Rizzo

et al.

Nature Reviews Psychology, Journal Year: 2024, Volume and Issue: 3(8), P. 552 - 567

Published: July 10, 2024

Language: Английский

Citations

19
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment DOI

Tamar Glatman Zaretsky,

Kathleen M. Jagodnik,

Robert Barsic

et al.

Current Neuropharmacology, Journal Year: 2024, Volume and Issue: 22(4), P. 636 - 735

Published: Jan. 5, 2024

Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to traumatic experience. An estimated 12 million U.S. adults are presently affected by this disorder. Current treatments include psychological therapies (e.g., exposure-based interventions) and pharmacological selective serotonin reuptake inhibitors (SSRIs)). However, significant proportion of patients receiving standard-of-care for PTSD remain symptomatic, new approaches other trauma-related conditions greatly needed. Psychedelic compounds alter cognition, perception, mood currently being examined their efficacy in treating despite current status as Drug Enforcement Administration (DEA)- scheduled substances. Initial clinical trials have demonstrated the potential value psychedelicassisted therapy treat psychiatric disorders. In comprehensive review, we summarize state science care, including shortcomings. We review studies psychedelic interventions PTSD, disorders, common comorbidities. The classic psychedelics psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT) DMT-containing ayahuasca, well entactogen 3,4-methylenedioxymethamphetamine (MDMA) dissociative anesthetic ketamine, reviewed. For each drug, present history use, somatic effects, pharmacology, safety profile. rationale proposed mechanisms use traumarelated disorders discussed. This concludes with an in-depth consideration future directions applications maximize therapeutic benefit minimize risk individuals communities impacted conditions.

Language: Английский

Citations

16
Targeted memory reactivation to augment treatment in post-traumatic stress disorder DOI

A.C. van der Heijden,

Ysbrand D. van der Werf, Odile A. van den Heuvel

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(16), P. 3735 - 3746.e5

Published: Aug. 1, 2024

Language: Английский

Citations

5
Parents’ Experience During Wartime: Vulnerability, Complexity, and Parental Functioning DOI Creative Commons

Elad Mijalevich-Soker,

Orit Taubman – Ben‐Ari

Journal of Loss and Trauma, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: Feb. 17, 2025

Language: Английский

Citations

0
The Measurement of Functioning as an Outcome in Intervention Studies Targeting Intrusive Memories of Trauma: A Narrative Review DOI Creative Commons
Emily A. Greenfield, Oliver Mason, Emily A. Holmes

et al.

Published: Feb. 19, 2025

Abstract There has been a call for innovative, low-cost and simple treatments people who have experienced trauma. The proposal that targeting intrusive memories could the downstream effect of reducing other posttrauma symptoms or preventing their emergence prompted development single-symptom interventions memories, drawing on cognitive neuroscience models memory consolidation reconsolidation. To understand full therapeutic impact, evaluations effectiveness should include measures broad outcomes (i.e. functioning), in addition to intrusion-related measures. This narrative review examined whether intervention studies after real-world trauma measured functioning as an outcome, if so, how. Twenty-five were included, 17 which included measure functioning. Functional not consistently rigorous informative way. We make recommendations address these issues propose ways can be effectively assessed future work.

Language: Английский

Citations

0
Exploring the potential of psychedelic-assisted psychotherapy for moral injury: A scoping review DOI

Viktoriia Kurkova,

Olga Winkler, Andrew J. Greenshaw

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111333 - 111333

Published: March 1, 2025

Language: Английский

Citations

0
Advances in the Management of Trauma Disorders DOI
Gabriella E. Hamlett,

Molly B. Schiffer,

Jonathan Hershfield

et al.

Advances in Psychiatry and Behavioral Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Stellate Ganglion Block Reduces Anxiety Symptoms by Half: A Case Series of 285 Patients DOI Open Access
James H. Lynch, Sean W. Mulvaney, Craig J. Bryan

et al.

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(6), P. 958 - 958

Published: June 6, 2023

The stellate ganglion block (SGB) procedure has been used successfully for over twelve years to treat thousands of patients suffering from posttraumatic stress disorder (PTSD). Level 1b evidence supports this use SGB, but no studies date have reported specifically on anxiety symptom improvements following SGB. We collected Generalized Anxiety Disorder questionnaire (GAD-7) scores pre-procedure and at 1-week 1-month post-procedure 285 patients. mean baseline GAD-7 score 15.9 (indicating severe anxiety) declined significantly SGB treatment. Changes in ≥ 4 were considered clinically meaningful. From 1 week, the dropped by 9.0 points (95% CI = 8.3-9.7, p < 0.001, d 1.8), with 211 (79.6%) demonstrating meaningful improvement. Furthermore, month, 8.3 7.6-9.0, 1.7), 200 (75.5%) treatment resulted a decrease twice minimal important difference treating least month Given results retrospective observational study, larger prospective should be conducted determine effects as novel therapeutic generalized other disorders.

Language: Английский

Citations

11
A Harm Reduction Framework for Integrated Treatment of Co-Occurring Opioid Use Disorder and Trauma-Related Disorders DOI
Benjamin S. Israel, Annabelle M. Belcher, Julián D. Ford

et al.

Journal of Dual Diagnosis, Journal Year: 2024, Volume and Issue: 20(1), P. 52 - 85

Published: Jan. 2, 2024

The opioid epidemic has exposed a gulf in mental health research, treatment, and policy: Most patients with comorbid trauma-related disorder (TRD) use (OUD) (TRD + OUD) remain undiagnosed or unsuccessfully treated for the combination of TRD symptoms use. treatments tend to be psychotherapies that are not accessible practical many individuals OUD, due treatment models systematically incorporating principles harm reduction (HR). HR practices prioritize flexibility unequivocally improve outcomes save lives OUD. Considering urgent need OUD outcomes, we propose fields can meaningfully reconciled by integrating classic phasic TRD. Adding "prestabilization" phase – largely analogous precontemplation Stage Change creates opportunities advance clinical practice, policies potentially patient outcomes.

Language: Английский

Citations

4