Frontiers in Psychiatry,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 22, 2023
Posttraumatic
stress
disorder
(PTSD)
is
a
chronic
resulting
from
exposure
to
traumatic
events.
In
recent
years,
sympathetic
nerve
blocks
have
gained
interest
as
an
emerging
treatment
modality
for
PTSD.
They
been
shown
reduce
autonomic
dysfunction
associated
with
PTSD
symptoms,
particularly
in
refractory
and
treatment-resistant
patients.
However,
there
limited
evidence
regarding
the
technique’s
effectiveness
Therefore,
this
scoping
review
was
designed
update
summarize
current
literature
on
topic
inform
design
of
future
clinical
trials
studies.
Our
22
studies
(mostly
case
reports
series)
included
1,293
patients
who
received
blocks,
primarily
military
service
members
veterans,
median
age
42.2
years.
0.5%
Ropivacaine
preferred
anesthetic,
right
sided
stellate
ganglion
block
most
commonly
used
technique.
Relapse
symptoms
reported
commonly,
additional
sessions.
Most
side
effects
were
mild
transient.
Despite
encouraging
results,
we
remain
cautious
interpreting
benefit
technique
due
lack
sufficient
standardized
trial
data,
heterogeneity
potential
bias
reporting.
Future
should
focus
evaluating
addressing
effectiveness,
safety,
tolerability,
indications.
Scandinavian Journal of Pain,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 1, 2025
Abstract
Objectives
A
significant
subset
of
patients
with
mental
health
disorders
(MHDs)
fail
to
respond
standard
management
and
are
termed
as
treatment-resistant.
This
cohort
has
limited
options
for
managing
their
condition.
Autonomic
dysfunction
been
reported
in
the
neurobiology
MHDs
including
anxiety,
depression,
obsessive-compulsive
disorder
(OCD),
panic
disorder,
bipolar
(BD).
Stellate
ganglion
block
(SGB)
is
an
emerging
treatment
that
dampens
sympathetic
activity
shown
be
benefit
post-traumatic
stress
disorder.
Methods
Patients
treatment-resistant
disparate
were
reviewed
by
a
multidisciplinary
team
comprising
psychiatrist,
clinical
psychologist,
pain
medicine
physician.
offered
SGB
novel
strategy
conditions.
Validated
outcome
measures
completed
at
baseline,
4
weeks,
16
weeks
post-intervention.
Results
Four
heterogenous
who
received
presented
this
report.
resulted
improvement
BD,
OCD
alcohol
addiction,
opioid
anxiety.
Conclusion
could
have
role
MHDs.
Frontiers in Physiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 10, 2025
Stellate
ganglion
blockade
(SGB)
is
a
practical
approach
to
managing
many
clinical
disorders.
Ultrasound-guided
SGB
currently
adopted
as
more
effective
and
safer
method
in
humans.
Developing
this
technique
rats
would
facilitate
further
study
of
application.
The
present
examined
physiological
responses
following
ultrasound-guided
Sprague-Dawley
rats.
Under
general
anesthesia,
lidocaine
containing
Chicago
blue
dye
(1.0%-1.5%
40-60
µL)
was
injected
into
the
unilateral
stellate
(SG).
Ptosis
observed
on
ipsilateral
right
(n
=
8)
or
left
7)
side
administration.
No
ptosis
noted
any
controls
by
0.9%
normal
saline
injection
6)
SG.
Heart
rate
(HR)
significantly
decreased
after
administration
(344
±
32
289
47
bpm;
p
0.015,
pre-vs.
after-injection),
but
not
saline,
HR
unaltered
injecting
variability
analysis
showed
that
with
caused
decrease
ratio
power
low-frequency
over
high-frequency.
Respiratory
rate,
body
temperature,
conditions
were
unchanged
all
rats,
regardless
SGB.
confirmed
be
distributed
SG
region.
bleeding
tissue
damage
evident
area.
Our
findings
suggest
effectively
inhibits
cervicothoracic
sympathetic
nerves
enhances
heart
variability,
controlling
are
likely
predominantly
associated
rat.
Brain Sciences,
Journal Year:
2025,
Volume and Issue:
15(2), P. 188 - 188
Published: Feb. 13, 2025
Purpose:
Determine
if
performing
ultrasound-guided,
bilateral,
two-level
cervical
sympathetic
chain
blocks
(2LCSB)
(performed
on
subsequent
days)
provides
durable
improvement
in
symptoms
associated
with
anxiety.
Methods:
A
retrospective
chart
review
was
conducted
between
January
2022
and
November
2024.
We
identified
114
patients
who
received
2LCSB
for
anxiety
symptoms.
Generalized
Anxiety
Disorder
7-Item
Scale
(GAD-7)
outcome
measure
scores
were
collected
at
baseline
three-months
post
procedure
71
males
43
females.
Results:
Out
of
patients,
99
(86.8%)
showed
a
long-lasting
their
GAD-7
scores.
Collected
forms
had
average
15.52
(14.99
16.40
females),
which
decreased
after
three
months
to
an
7.28
(6.96
7.81
females).
This
represents
52%
Conclusions:
In
individuals
treated
2LCSB,
GAD-related
improved
by
least
3
regardless
initial
severity.
Military Medicine,
Journal Year:
2024,
Volume and Issue:
189(11-12), P. e2573 - e2577
Published: May 17, 2024
ABSTRACT
Purpose
The
purpose
of
the
study
was
to
determine
whether
performing
ultrasound-guided,
bilateral
stellate
ganglion
blocks
(SGBs;
performed
on
subsequent
days)
improved
traumatic
brain
injury
(TBI)
symptoms.
Methods
A
retrospective
chart
review
conducted
for
time
period
between
August
2022
and
February
2023
identify
patients
who
received
bilateral,
2-level
(C6
C4)
SGBs
PTSD
symptoms
but
also
had
a
history
TBI.
Neurobehavioral
Symptoms
Inventory
(NSI)
scores
were
collected
at
baseline,
1
week,
month
post-treatment
in
14
males
9
females.
Results
Out
23
patients,
22
showed
improvement
their
NSI
scores.
baseline
average
score
42.7;
week
18.8;
20.1.
This
represents
53%
month.
Conclusion
use
may
be
indicated
treating
with
concomitant
diagnoses
mild-to-moderate
Neurorehabilitation,
Journal Year:
2024,
Volume and Issue:
55(3), P. 385 - 396
Published: July 12, 2024
BACKGROUND:
For
decades,
thousands
of
active-duty
service
members
have
sought
treatment
for
trauma
exposure.
Stellate
ganglion
block
(SGB)
is
a
fast-acting
nerve
documented
in
medical
literature
nearly
century
that
has
shown
promise
as
potentially
life-altering
post-traumatic
stress
(PTS).
OBJECTIVE:
This
review
aims
to
answer
the
practical
questions
those
who
support
individuals
suffering
from
trauma:
(1)
SGB’s
safety
profile
(2)
efficacy
data
(3)
potential
advantages
and
limitations,
(4)
cross-cultural
application
example,
(5)
use
SGB
combination
with
talk
therapy
optimize
clinical
outcomes.
METHODS:
The
current
body
literature,
include
several
large
case
series,
meta-analyses,
sufficiently
powered
randomized
controlled
trial,
were
reviewed,
presented
describe
history
emotional
symptoms
address
objectives
this
review.
RESULTS:
Critical
consideration
given
on
evolution
safety-related
technologies.
Advantages
such
decreased
barriers
care,
rapid
onset,
dropout
limitations
non-response,
adverse
effects,
misconceptions
about
are
then
described.
Finally,
explored
based
deployment
Israel.
CONCLUSION:
associated
level
1B
evidence
reassuring
profile.
Evolving
model
care
through
combined
effective
biological
treatments
like
informed
offers
hopeful
path
forward
supporting
suffer
stress.
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1193 - 1193
Published: Nov. 27, 2024
Background/Objectives:
The
aim
of
this
study
was
to
determine
if
performing
ultrasound-guided,
bilateral,
two-level
cervical
sympathetic
chain
blocks
(2LCSBs)
(performed
on
subsequent
days)
improves
symptoms
associated
with
traumatic
brain
injury
(TBI)
that
do
not
overlap
posttraumatic
stress
disorder
(PTSD).
Methods:
A
retrospective
chart
review
conducted
between
August
2022
and
February
2023.
We
identified
twenty
patients
who
received
bilateral
2LCSBs
for
PTSD
anxiety
also
had
a
history
TBI.
Neurobehavioral
Symptom
Inventory
(NSI)
scores
were
collected
at
baseline,
one
week,
month
post
treatment
in
13
males
7
females.
sub-analysis
the
first
ten
questions
NSI,
which
we
as
overlapping
or
symptoms,
generated
an
NSI
sub-score.
Results:
Out
20
patients,
all
showed
improvement
their
sub-scores.
sub-scores
baseline
average
15.45
(on
40-point
scale);
score
week
8.30;
7.80.
This
represents
49.51%
TBI
did
month.
Conclusions:
use
may
be
helpful
treating
TBI,
regardless
presence
comorbid
symptoms.
Translational Psychiatry,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 29, 2024
Abstract
Empirically
supported
treatments
for
posttraumatic
stress
disorder
(PTSD)
exist,
but
research
suggests
these
therapies
are
less
effective,
acceptable,
and
feasible
to
deliver
active
duty
service
members
(SMs)
compared
civilians.
Stellate
ganglion
block
(SGB)
procedure,
in
which
a
local
anesthetic
is
injected
around
the
cervical
sympathetic
chain
or
stellate
temporarily
inhibit
nervous
activity,
gaining
popularity
as
an
alternative
PTSD
treatment
military
settings.
However,
it
unknown
whether
certain
symptoms
more
responsive
SGB
than
others.
The
current
study
involved
secondary
analysis
of
data
collected
from
previous
randomized
controlled
trial
sham
(normal
saline)
injection
(
N
=
113
SMs).
were
assessed
via
clinical
interview
self-report
at
baseline
8
weeks
post-SGB
sham.
Logistic
regression
analyses
showed
that
marked
alterations
arousal
reactivity
symptom
cluster
demonstrated
greatest
severity
reductions
after
SGB,
relative
reexperiencing
also
pronounced
response
clinician-rated
not
self-reported
outcomes.
Post-hoc
item-level
suggested
findings
driven
by
hypervigilance,
concentration
difficulties,
sleep
disturbance,
whereas
physiological
reactions
trauma
cues,
emotional
intrusions.
Our
align
with
burgeoning
literature
positioning
potential
novel
adjunctive
treatment.
Results
could
guide
future
hypothesis-driven
on
mediators
therapeutic
change
during
SMs.
