Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: March 26, 2021

Since late 2019, the novel coronavirus SARS-CoV-2 has introduced a wide array of health challenges globally. In addition to complex acute presentation that can affect multiple organ systems, increasing evidence points long-term sequelae being common and impactful. The worldwide scientific community is forging ahead characterize range outcomes associated with infection; however underlying assumptions in these studies have varied so widely resulting data are difficult compareFormal definitions needed order design robust consistent Long COVID consistently capture variation outcomes. Even condition itself goes by three terms, most "Long COVID", but also "COVID-19 syndrome (PACS)" or, "post-acute infection (PASC)". present study, we investigate used literature published date compare them against available from electronic records patient-reported information collected via surveys. holds potential produce second public crisis on heels pandemic itself. Proactive efforts identify characteristics this heterogeneous imperative for rigorous effort mitigate threat.

Language: Английский

---

Effects of a Comprehensive Pulmonary Rehabilitation in Severe Post-COVID-19 Patients

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(5), P. 2695 - 2695

Published: March 7, 2021

Background: Severe COVID-19 infection often leads to impairments requiring pulmonary rehabilitation (PR) following the acute phase. Little is known about efficacy of PR in these patients. We therefore compared post-COVID-19 patients (PG) referred with other lung diseases (LG). Methods: 99 PG were admitted PR. In a prospective design, results collected and LG 2019 (n = 419) according Functional Independence Measurement (FIM), Cumulative Illness Rating Scale (CIRS), 6-min walk test (6-MWT), duration PR, Feeling Thermometer (FT). Results: According age, sex, CIRS, both groups showed no significant differences. The improvements 6-MWT pre post comparison on average 180 (±101) meters for 102 (±89) (p < 0.001). FT enhancement 21 (±14) points 17 (±16) 0.039), while FIM significantly increased by 11 (±10) 7 (±8) Conclusions: Comprehensive very effective FIM, FT. Therefore, we recommend severe infections.

Language: Английский

---

A systematic review on physical function, activities of daily living and health-related quality of life in COVID-19 survivors

Chronic Illness, Journal Year: 2022, Volume and Issue: 19(2), P. 279 - 303

Published: April 11, 2022

To analyze the published studies that investigated physical function, activities of daily living and health-related quality life in COVID-19 survivors.Systematic review.We searched MEDLINE/PubMed, Scopus, SciELO, Cochrane Library for evaluated after from earliest date available to July 2021. Two independent reviewers screened selected studies. The Newcastle Ottawa Scale was used evaluate methodological quality.We included 35 this systematic review. Of included, 28 were cohort, 7 cross-sectional demonstrated survivors had reduced levels living, life. Furthermore, incomplete recovery performance observed 1 6 months post-infection.Physical disability reduction is a common condition post-COVID-19 impairments may persist up months. Researchers clinicians can use these findings understand potential disabilities rehabilitation needs people recovering COVID-19.

Language: Английский

---

S1-Leitlinie Long-/Post-COVID

Pneumologie, Journal Year: 2022, Volume and Issue: 76(12), P. 855 - 907

Published: Dec. 1, 2022

The German Society of Pneumology initiated 2021 the AWMF S1 guideline Long COVID/Post-COVID. In a broad interdisciplinary approach, this was designed based on current state knowledge.The clinical recommendations describe COVID/Post-COVID symptoms, diagnostic approaches, and therapies.In addition to general consensus introduction, subject-specific approach taken summarize has an explicit practical claim will be developed adapted by author team increase in knowledge.Die Deutsche Gesellschaft für Pneumologie hat die S1-Leitlinie Long-/Post-COVID initiiert. einem breiten interdisziplinären Ansatz wurde diese basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt Long- bzw. Post-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen konsentierten Einführung ein fachspezifischer Zugang gewählt, den zusammenfasst.Die Leitlinie einen explizit praktischen Anspruch wird Wissenszugewinn vom Autorenteam weiterentwickelt adaptiert.

---

The pulmonary rehabilitation effect on long covid‐19 syndrome: A systematic review and meta‐analysis

Physiotherapy Research International, Journal Year: 2024, Volume and Issue: 29(2)

Published: Feb. 22, 2024

Abstract Objectives This systematic review and meta‐analysis aims to evaluate the efficacy of pulmonary rehabilitation (PR) in improving dyspnea, fatigue, physical activity, quality life, anxiety depression patients with Long COVID‐19 (LC). The impact PR on LC a comparison face‐to‐face telerehabilitation approaches was explored. Methods followed PRISMA guidelines registered PROSPERO. A literature search included PubMed, Web Science, Cochrane Library until January 2023. No language filters were applied. Randomized controlled trials, non‐randomized observational studies included. risk bias assessed using appropriate tools. Descriptive analysis performed. Forest plots presented results. Statistical analyses conducted Metafor Package R v.3.4.2. Results/Findings 16 patients. total 1027 adults varied design, seven studies, three quasi‐experimental six randomized trials. Dyspnea, function, psychological state, fatigue as outcomes. found that had significant positive effect life (both global domain), anxiety, depression. However, not significant. Heterogeneity observed some analyses, publication certain Age study design identified potential moderators. Both interventions improved studied outcomes, only differences domain favoring group. Implications Physiotherapy Practice state patients, but fatigue. Face‐to‐face have similar effects, except for life.

Language: Английский

---

Pulmonary Rehabilitation in COVID-19 patients: A scoping review of current practice and its application during the pandemic

Turkish Journal of Physical Medicine and Rehabilitation, Journal Year: 2020, Volume and Issue: 66(4), P. 480 - 494

Published: Dec. 21, 2020

The novel coronavirus-2019 (COVID-19) pandemic originated in Wuhan, China late December 2019, and rapidly spread to more than 200 countries all around the globe.Currently, there are 19.6 million confirmed cases with 727,435 fatalities. [1][4][5][6] On other hand, children may remain asymptomatic most only detected on laboratory testing.[5] main concern COVID-19 is involvement of lungs respiratory system which result dyspnea, low blood oxygen saturation, failure, thereby, requiring mechanical ventilation, [3,4] mostly those having comorbid conditions such as diabetes mellitus, obesity, ischemic heart disease, cancer, post-surgery, chronic obstructive pulmonary disease (COPD). [3,5]

Language: Английский

---

Functional outcome after inpatient rehabilitation in postintensive care unit COVID-19 patients: findings and clinical implications from a real-practice retrospective study

European Journal of Physical and Rehabilitation Medicine, Journal Year: 2021, Volume and Issue: 57(3)

Published: July 1, 2021

BACKGROUND: Coronavirus disease 2019 (COVID-19) pandemic is quickly spreading worldwide, with survivors that suffer functional impairments a consequent key role of rehabilitation in this context. To date, there lack findings on the postacute COVID-19 patients.AIM: Thus, we aimed at describing patient-tailored plan outcome hospitalized patients.DESIGN: Real-practice retrospective study.SETTING: Inpatients Rehabilitation Unit.POPULATION: Postacute patients.METHODS: Medical records patients referred to an Italian Unit from March 10th, 2020 April 30th, were collected. All underwent rehabilitative (30 minutes/set, 2 times/day), improve gas exchanges, reducing dyspnoea, and improving muscle function. At admission (T0) discharge (T1), evaluated as measures: Barthel Index (BI), modified Research Council Dyspnea Scale, 6-Minute Walking Test (6-MWT) Borg Rating Perceived Exertion (RPE) scale. We also assessed: type respiratory supports needed, pulmonary function, coagulation inflammation markers length stay (LOS) Unit.RESULTS: included 41 (25 male 19 female), mean aged 72.15±11.07 years. Their LOS was 31.97±9.06 days, 39 successfully completed treatment deceased. found statistically significant improvement BI (84.87±15.56 vs. 43.37±26.00; P<0.0001), 6-MWT (303.37±112.18 240.0±81.31 meters; P=0.028), RPE scale (12.23±2.51 16.03±2.28; P<0.0001).CONCLUSIONS: These suggest might beneficiate motor treatment. However, further studies are advised better understand long-term sequelae disease.CLINICAL REHABILITATION IMPACT: This study provides evidence inpatients through

Language: Английский

---

Surviving COVID-19 After Hospital Discharge: Symptom, Functional, and Adverse Outcomes of Home Health Recipients

Annals of Internal Medicine, Journal Year: 2020, Volume and Issue: 174(3), P. 316 - 325

Published: Nov. 23, 2020

Little is known about recovery from coronavirus disease 2019 (COVID-19) after hospital discharge.To describe the home health of patients with COVID-19 and risk factors associated rehospitalization or death.Retrospective observational cohort.New York City.1409 admitted to care (HHC) between 1 April 15 June 2020 hospitalization.Covariates outcomes were obtained mandated OASIS (Outcome Assessment Information Set). Cox proportional hazards models used estimate hazard ratio (HR) death.After an average 32 days in HHC, 94% discharged most achieved statistically significant improvements symptoms function. Activity-of-daily-living dependencies decreased 6 (95% CI, 5.9 6.1) 1.2 (CI, 1.1 1.3). Risk for death was higher male (HR, 1.45 [CI, 1.04 2.03]); White 1.74 1.22 2.47]); heart failure 2.12 1.41 3.19]), diabetes complications 1.71 1.17 2.52]), 2 more emergency department visits past months 1.78 1.21 2.62]), pain daily all time 1.46 1.05 2.05]), cognitive impairment 1.49 2.13]), functional 1.09 1.00 1.20]). Eleven (1%) died, 137 (10%) rehospitalized, 23 (2%) remain on service.Care provided by agency. HHC discharge not available.Symptom burden dependence common at admission but improved patients. Comorbid conditions diabetes, as well characteristics present admission, identified greatest adverse event.No direct funding.

Language: Английский

---

COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications

Journal of Alzheimer s Disease, Journal Year: 2020, Volume and Issue: 77(2), P. 459 - 504

Published: Sept. 9, 2020

COVID-19 is a severe infectious disease that has claimed >150,000 lives and infected millions in the United States thus far, especially elderly population. Emerging evidence shown virus to cause hemorrhagic immunologic responses, which impact all organs, including lungs, kidneys, brain, as well extremities. SARS-CoV-2 also affects patients’, families’, society’s mental health at large. There growing of re-infection some patients. The goal this paper provide comprehensive review SARS-CoV-2-induced disease, its mechanism infection, diagnostics, therapeutics, treatment strategies, while focusing on less attended aspects by previous studies, nutritional support, psychological, rehabilitation pandemic management. We performed systematic >1,000 articles included 425 references from online databases, including, PubMed, Google Scholar, California Baptist University’s library. patients go through acute respiratory distress syndrome, cytokine storm, hypercoagulable state, autonomic dysfunction, must be managed multidisciplinary team nursing, nutrition, rehabilitation. population those who are suffering Alzheimer’s dementia related illnesses seem higher risk. 28 vaccines under development, new strategies/protocols being investigated. future management for should include B-cell T-cell immunotherapy combination with emerging prophylaxis. illness aspect among most important side effects requires national plan prevention, diagnosis treatment.

Language: Английский

---

The lingering manifestations of COVID-19 during and after convalescence: update on long-term pulmonary consequences of coronavirus disease 2019 (COVID-19)

La radiologia medica, Journal Year: 2020, Volume and Issue: 126(1), P. 40 - 46

Published: Oct. 1, 2020

Language: Английский

---