Post-COVID-19 Condition Symptoms Among Emergency Department Patients Tested for SARS-CoV-2 Infection DOI Creative Commons
Patrick Archambault, Rhonda J. Rosychuk, Martyne Audet

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 22, 2023

Abstract Importance: Symptoms of Post-COVID-19 Condition (PCC) are non-specific and can occur due to other medical conditions, making it a challenge distinguish PCC from health conditions. Objective: To compare the proportion emergency department (ED) patients who developed symptoms consistent with between those tested positive for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection time-matched negative. Design: Observational cohort study that enrolled consecutive eligible October 18, 2020, February 28, 2022. Setting: Thirty-three Canadian COVID-19 ED Rapid Response Network sites. Participants: Eligible were aged ≥18 years SARS-CoV-2. We excluded not contacted after 5 attempts, unable communicate language or cognitive barriers, deceased, reported subsequent test symptomatic infection. Exposure: SARS-CoV-2 Main outcome Measure:Based on World Health Organization (WHO) clinical case definition, our primary was reporting at least one new PCC-consistent symptom arising in three months visit still present three-month mark lasted >2 months. Results: Of 29,838 individuals assessed eligibility, 6,723 included (58% positive; 51% female; mean age, 54.4 [SD: 17.9]). Among 3,933 test-positive patients, 38.9% (1532/3933, 95% CI: 37.4-40.4%) 3 compared 20.7% (578/2790, 19.2-22.2%) test-negative patients. Test-positive experiencing each individual twice as often The top most frequently by post-exertional malaise, dyspnea memory problems. important predictor during index (adjusted OR=4.42). Conclusions Relevance: Over one-third proven acute met criteria post-index visit, however five also highlighting lack specificity WHO definition. Testing phase suspected should continue until specific biomarkers become available diagnosis treatment referral. Trial registration: Clinicaltrials.gov, no. NCT04702945

Language: Английский

Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection DOI Creative Commons
Patrick Archambault, Rhonda J. Rosychuk, Martyne Audet

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 30, 2024

Language: Английский

Citations

4
Determinants of SARS-CoV-2 IgG response and decay in Canadian healthcare workers: A prospective cohort study DOI Creative Commons
Nicola Cherry, Anil Adisesh, Igor Burstyn

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 42(5), P. 1168 - 1178

Published: Jan. 25, 2024

Healthcare workers (HCWs) from an interprovincial Canadian cohort gave serial blood samples to identify factors associated with anti-receptor binding domain (anti-RBD) IgG response the SARS-CoV-2 virus. Members of HCW donated four months after their first immunization and again at 7, 10 13 months. Date type immunizations dates infection were collected each contacts, together information on immunologically-compromising conditions current therapies. Blood analyzed centrally for anti-RBD anti-nucleocapsid (Abbott Architect, Abbott Diagnostics). Records testing public health agencies used assess impact reporting errors estimates random-effects multivariable model fitted data. 2752 4567 vaccinated participants agreed donate least one sample. Modelling titer 8903 showed increase in vaccine dose infection. A decrease was found number since vaccination or infection, sharpest decline third dose. An regime that included mRNA1273 (Moderna) resulted higher IgG. Participants multiple sclerosis, rheumatoid arthritis taking selective immunosuppressants, tumor necrosis factor inhibitors, calcineurin inhibitors antineoplastic agents had lower Supplementary analyses those side-effects vaccination, no relation obesity titers women immunized early mid-pregnancy. Sensitivity analysis results suggested important bias self-report Creation a prospective central credibility presented here. Serial serology assessments, longitudinal analysis, provided effect enhanced accuracy clearer understanding medical other affecting vaccination.

Language: Английский

Citations

2
Immune escape and waning immunity of COVID-19 monovalent mRNA vaccines against symptomatic infection with BA.1/BA.2 and BA.5 in Japan DOI Creative Commons
Takeshi Arashiro,

Yuzo Arima,

Jin Kuramochi

et al.

Vaccine, Journal Year: 2023, Volume and Issue: 41(47), P. 6969 - 6979

Published: Oct. 13, 2023

Repeated emergence of variants with immune escape capacity and waning immunity from vaccination are major concerns for COVID-19. We examined whether the surge in Omicron subvariant BA.5 cases was due to or through vaccine effectiveness (VE) evaluation.A test-negative case-control study conducted 16 clinics/hospitals during BA.1/BA.2-dominant BA.5-dominant periods. VE against symptomatic infection estimated after adjusting age, sex, comorbidity, occupation, testing frequency, prior infection, close contact history, clinic/hospital, week, preventive measures. Absolute (aVE) calculated 2/3/4 doses, compared unvaccinated. Relative (rVE) calculated, comparing 3 vs 2 4 doses.13,025 individuals were tested periods similar baseline characteristics. For BA.1/BA.2, aVE 52 % (95 %CI:34-66) 14 days-3 months post-dose 2, 42 (29-52) > 6 71 (64-77) 3, 68 (52-79) 3-6 3. rVE 49 (38-57) 45 (18-63) BA.5, 56 (27-73) 32 (12-47) 70 (61-78) 59 (48-68) 50 (29-64) 74 (61-83) ≥ days 4. (45-65) 39 (27-48) 25 (-2-45) 30 (-6-54) 4.Booster doses initially provided high protection at a level that BA.1/BA.2. However, seemed shorter-lasting which likely contributed surge. Furthermore, low even among recent vaccinees. These results support introduction variant-containing vaccines emphasize need longer duration protection.

Language: Английский

Citations

5
Leveraging a clinical emergency department dataset to estimate two-dose COVID-19 vaccine effectiveness and duration of protection in Canada DOI Creative Commons
Daniel K. Ting, Rhonda J. Rosychuk, Jeffrey P. Hau

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 42(23), P. 126058 - 126058

Published: June 15, 2024

During the COVID-19 pandemic, clinical care shifted toward virtual and Emergency Department care. We explored feasibility of mRNA vaccine effectiveness (VE) estimation against SARS-CoV-2-related visits hospitalizations using prospectively collected data. estimated two-dose VE a test-negative design data from 10 participating sites Canadian Rapid Response Network (CCEDRRN). included patients presenting with symptoms nucleic acid amplification testing for SARS-CoV-2 between July 19 December 31, 2021. excluded unclear vaccination one or more than 2 doses by their visit. Among 3,405 eligible patients, adjusted was 93.3 % (95 CI 87.9–96.3 %) 7–55 days, sustained over 80 through 139 days post-vaccination. In stratified analyses, similar among select immune-compromising conditions, chronic kidney disease, lung unstable housing, reported illicit substance use. Two-dose visit high sustained, including vulnerable subgroups. Compared to administrative datasets, active enrolment enables standardization access indication supports separate assessment special population other settings, Departments consistently function during crises when alternate healthcare sectors become variably closed. Trial registration: Clinicaltrials.gov, NCT0470294.

Language: Английский

Citations

1
Parent and family characteristics associated with reported pediatric influenza vaccination in a sample of Canadian digital vaccination platform users. An exploratory, cross-sectional study in the 2018-2019 influenza season DOI Creative Commons
Katherine Atkinson, Blaise Ntacyabukura, Steven Hawken

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: July 22, 2024

Seasonal vaccination remains one of the best interventions to prevent morbidity and mortality from influenza in children. Understanding characteristics parents who vaccinate their children can inform communication strategies encourage immunization. Using a cross-sectional study, we described parental people reported vaccinating against during 2018/2019 cohort Canadian digital immunization record users. Data was collected free, Pan-Canadian tool, CANImmunize. Eligible accounts contained at least "child/dependent" record. Each characteristic (gender, age, family size, etc) tested for association with pediatric vaccination, multivariate logistic regression model fit. A total 6,801 CANImmunize met inclusion criteria. After collapsing dataset, final sample 11,381 unique dyads. Influenza 32.3% 42.0% parents. In analysis, receiving seasonal vaccine were most strongly associated reporting (OR 17.05, 95% CI 15.08, 19.28). Having larger size fewer transactions study period not vaccination. While there are several limitations this large-scale these results help future research area. Digital technologies may provide valuable source coverage data explore associations between individual behavior. Policy makers considering messaging want tailor efforts based on further improve uptake.

Language: Английский

Citations

1
Characteristics and outcomes of patients with COVID-19 who return to the emergency department: a multicentre observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) DOI
Rhonda J. Rosychuk, Jaspreet Khangura,

Sylvia S Ortiz

et al.

Emergency Medicine Journal, Journal Year: 2024, Volume and Issue: 41(4), P. 210 - 217

Published: Feb. 16, 2024

Unplanned return emergency department (ED) visits can reflect clinical deterioration or unmet need from the original visit. We determined characteristics and outcomes of patients with COVID-19 who to ED for COVID-19-related revisits.

Language: Английский

Citations

0
Perceived Risk for Severe COVID-19 and Oral Antiviral Use Among Antiviral-Eligible US Adults DOI Creative Commons
Kate Penrose, Avantika Srivastava, Yanhan Shen

et al.

Infectious Diseases and Therapy, Journal Year: 2024, Volume and Issue: 13(8), P. 1743 - 1757

Published: June 23, 2024

Oral antiviral medications are important tools for preventing severe COVID-19 outcomes. However, their uptake remains low reasons that not entirely understood. Our study aimed to assess the association between perceived risk outcomes and oral use among those who were eligible treatment based on Centers Disease Control Prevention (CDC) guidelines. We surveyed 4034 non-institutionalized US adults in April 2023, report findings from 934 antiviral-eligible participants with at least one confirmed SARS-CoV-2 infection since December 1, 2021 no current long COVID symptoms. Survey weights used yield nationally representative estimates. The primary exposure of interest was whether themselves be "at high COVID-19." outcome a within 5 days suspected infection. Only 18.5% considered 16.8% 15.9% took antivirals any time or infection, respectively. In contrast, 79.8% aware treatments COVID-19. Perceived high-risk status associated being more likely (adjusted prevalence ratio [aPR]: 1.11 [95% confidence interval (CI) 1.03–1.20]), prescribed (aPR 1.47 CI 1.08–2.01]), take 1.61 1.16–2.24]) 1.72 1.23–2.40]). Despite widespread awareness availability antivirals, than 80% did receive them. suggest differences actual (based CDC guidelines) may partially explain this uptake.

Language: Английский

Citations

0
Cervical Cancer Screening and Prevention Uptake in Females with Autism Spectrum Disorder DOI
Yachin Chen, James H. Powers, Christopher J. McDougle

et al.

Journal of Autism and Developmental Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Language: Английский

Citations

0
Accuracy of the Canadian COVID-19 Mortality Score (CCMS) to predict in-hospital mortality among vaccinated and unvaccinated patients infected with Omicron: a cohort study DOI Creative Commons
Corinne M. Hohl,

David Seonguk Yeom,

Justin W. Yan

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(11), P. e083280 - e083280

Published: Nov. 1, 2024

Objective The objective is to externally validate and assess the opportunity update Canadian COVID-19 Mortality Score (CCMS) predict in-hospital mortality among consecutive non-palliative patients infected with Omicron subvariants at a time when vaccinations were widespread. Design This observational study validated CCMS in an external cohort variants dominant. We assessed potential rule improve its performance by recalibrating adding vaccination status subset of from provinces access data created adjusted (CCMS adj ). followed discharged for 30 days after their index emergency department visit or entire hospital stay if admitted. Setting External validation CCMS: 36 hospitals participating Emergency Department Rapid Response Network (CCEDRRN). Update : 14 CCEDRRN data. Participants Consecutive presenting departments. Main outcome measures In-hospital mortality. Results Of 39 682 eligible patients, 1654 (4.2%) died. included age, sex, residence type, arrival mode, chest pain, severe liver disease, respiratory rate level support predicted area under curve (AUC) 0.88 (95% CI 0.87 0.88) validation. Updating create changed weights homelessness, but only marginally improved performance, while did not. had AUC 0.91 0.89 0.92) scores <10 categorised as low risk <1.6%. A score>15 observed >56.8%. Conclusions remained highly accurate predicting through recalibration. Adding not performance. can be used inform patient prognosis, goals care conversations guide clinical decision-making COVID-19.

Language: Английский

Citations

0
Exploring the association of social isolation and loneliness on the experience of COVID-19 infection and hospitalization in the Japanese population: the JACSIS study DOI
Hiroshi Murayama, Takumi Suda, Isuzu Nakamoto

et al.

Social Psychiatry and Psychiatric Epidemiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Language: Английский

Citations

0