Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal‐dominant Alzheimer's disease DOI Creative Commons
Edmarie Guzmán‐Vélez,

Angelys Rivera‐Hernández,

Sofia Fabrega

et al.

Alzheimer s & Dementia Translational Research & Clinical Interventions, Journal Year: 2024, Volume and Issue: 10(4)

Published: Oct. 1, 2024

Language: Английский

Sleep disparities in the United States: comparison of logistic and linear regression with stratification by race DOI Creative Commons
Irene A. Doherty,

Mary Ellen Wells

Sleep Epidemiology, Journal Year: 2025, Volume and Issue: unknown, P. 100106 - 100106

Published: Jan. 1, 2025

Language: Английский

Citations

1

From wearable sensor data to digital biomarker development: ten lessons learned and a framework proposal DOI Creative Commons
Paola Daniore, Vasileios Nittas, Christina Haag

et al.

npj Digital Medicine, Journal Year: 2024, Volume and Issue: 7(1)

Published: June 18, 2024

Wearable sensor technologies are becoming increasingly relevant in health research, particularly the context of chronic disease management. They generate real-time data that can be translated into digital biomarkers, which provide insights our and well-being. Scientific methods to collect, interpret, analyze, translate from wearables biomarkers vary, systematic approaches guide these processes currently lacking. This paper is based on an observational, longitudinal cohort study, BarKA-MS, collected wearable physical rehabilitation people living with multiple sclerosis (MS). Based experience we discuss ten lessons learned relation biomarker development across key study phases. We then summarize a guiding framework (DACIA) aims informs use for management future research teaching.

Language: Английский

Citations

8

Wearable Device–Based Intervention for Promoting Patient Physical Activity After Lung Cancer Surgery DOI Creative Commons
Jung Hee Lee, Sunga Kong, Sumin Shin

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(9), P. e2434180 - e2434180

Published: Sept. 20, 2024

Importance Emerging evidence suggests that wearable devices are feasible for monitoring physical activity among patients with lung cancer. However, the association between and improvement in patient recovery after surgery remains underexplored. Objective To evaluate effects of a device intervention on activity, cardiopulmonary function, health-related quality life (HRQOL) cancer surgery. Design, Setting, Participants This nonrandomized clinical trial historical control was conducted at single tertiary center (Samsung Comprehensive Cancer Center) Seoul, South Korea, October 18, 2018, May 24, 2019. Patients were included if they had suspected or confirmed non–small cell scheduled curative more extensive than lobectomy an Eastern Cooperative Oncology Group status 0 1. compared participants from data collected September 20, 2017, 10, as part Coordinated Approach to Patients’ Health Lung (CATCH-LUNG) prospective cohort study. Data analysis performed June 21 July 16, 2020. Intervention A personalized exercise regimen monitored via administered home 3 stages: preoperative (from diagnosis surgery), immediate discharge 2 months later postoperative 6 surgery). Control received usual care. Main Outcomes Measures The primary outcome co–primary surgery, measured 6-minute walking distance (6MWD) number daily steps, using linear regression model. Secondary outcomes changes HRQOL, including function symptoms baseline weeks Additionally, (number steps time spent moderate-to-vigorous [MVPA]) (time MVPA) assessed secondary outcomes. Results 74 group (mean [SD] age, 60.4 [8.7] years; 31 [41.9%] men 43 [58.1%] women) 120 60.2 65 [54.2%] 55 [45.8%] women). Daily MVPA, 6MWD decreased initially but increased thereafter. larger decrease (−4877 [95% CI, −5861 −3893] vs −1753 −2968 −539] steps) By their by 2220 (95% 1006 3435) baseline, whereas did not return steps. significantly (12 321 8749-15 761] 10 118 7341-13 420]; P = .007) greater vigorous (33.6 13.5 59.8] 18.5 [5.7 40.8] minutes; .003) group. No difference found. better patient-reported score, 82.2 [17.3] 76.9 [17.5]; .04), less dyspnea 24.8 [27.1] 34.5 [31.6]; .03), pain 21.4 [20.2] 30.1 [26.8]; .01) 5.4[12.4] 12[23.3]; Conclusions Relevance In this trial, integration perioperative interventions improved (especially finding promising role personalizing rehabilitation strategies. Trial Registration ClinicalTrials.gov Identifier: NCT03215537

Language: Английский

Citations

5

Data from the All of Us research program reinforces existence of activity inequality DOI Creative Commons
Hayoung Jeong, Ali R. Roghanizad, Hiral Master

et al.

npj Digital Medicine, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 4, 2025

Large-scale and detailed analyses of activity in the United States (US) remain limited. In this work, we leveraged comprehensive wearable, demographic, survey data from All Us Research Program, largest most diverse population health study US to date, apply extend previous global findings on inequality within context US. We found that daily steps differed by sex at birth, age, body characteristics, geography, built environment. Quantifying using modified Gini index, a strong correlation with obesity prevalence (R2 = 0.804) moderate perceived walkability 0.426) gender gap 0.385). This demonstrates value digital technologies exploring understanding public practices while highlighting need examine complexities, including biopsychosocial factors may contribute inequality.

Language: Английский

Citations

0

'If It Doesn't Work for Me as a Researcher, Let Alone Others' : Understanding Wellbeing Through an Autoethnography of Wearable and Non-Wearable Technologies DOI
Sirinthip Roomkham

Published: April 23, 2025

Language: Английский

Citations

0

Large-scale digital phenotyping: Identifying depression and anxiety indicators in a general UK population with over 10,000 participants DOI
Yuezhou Zhang, Callum Stewart, Yatharth Ranjan

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0

A framework for remotely enabled co-design with young people: its development and application with neurodiverse children and their caregivers DOI Creative Commons
Anna Morris,

Stephen Douch,

Teodora Popnikolova

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 16, 2024

This paper describes an innovative Framework for Remotely Enabled Co-Design with Young people (FREDY), which details adaptable four-stage process generating design concepts children and other key stakeholders in a naturalistic inclusive way.

Language: Английский

Citations

2

Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations DOI Creative Commons
Jason J. Liu,

Beatrice Borsari,

Yunyang Li

et al.

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2

The Moderating Effect of Atypical Events on the Relationship between Heart Rate and Stress in Medical Residents working in an ICU: Exploratory Study (Preprint) DOI
Ruibei Li, Ujjwal Pasupulety,

Wellington Chang

et al.

Published: Oct. 21, 2024

BACKGROUND Residency is a critical period in physician’s training, characterized by significant physical, cognitive, and emotional demands that make residents highly susceptible to stress associated negative health outcomes. While physiological signals like heart rate have been explored as potential biomarkers of stress, their predictive utility high-stress environments such the intensive care unit (ICU) remains inconclusive, especially when factoring atypical events can further exacerbate resident levels. OBJECTIVE This study aimed investigate relationship between daily average (AHR) perceived among ICU examine moderating effect on this relationship. METHODS The TILES-2019 dataset collected longitudinal data from 44 who provided self-reported ratings wore Fitbit device track over 3-week period. main predictor variables were AHR occurrence (both work/life related hassles). primary outcome was level measured 7-point Likert scale. Linear mixed models (LMM) used analyze accounting for within-subject between-subject variance. Interaction effects also examined. RESULTS analysis revealed positive association (β = 0.032, P .04). However, attenuated presence -0.076, .20). We analyzed whether severity had an additional but found no statistical significance. CONCLUSIONS marker its moderated events. Future research should replicate these findings more diverse cohorts, assess generalizability broader populations, control confounding variables. Incorporating assessment could lead accurate context-sensitive interpretations data.

Language: Английский

Citations

0

Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal‐dominant Alzheimer's disease DOI Creative Commons
Edmarie Guzmán‐Vélez,

Angelys Rivera‐Hernández,

Sofia Fabrega

et al.

Alzheimer s & Dementia Translational Research & Clinical Interventions, Journal Year: 2024, Volume and Issue: 10(4)

Published: Oct. 1, 2024

Language: Английский

Citations

0