Ferroptosis as an emerging target in sickle cell disease

Current Research in Toxicology, Journal Year: 2024, Volume and Issue: 7, P. 100181 - 100181

Published: Jan. 1, 2024

Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of death characterized reactive oxygen species (ROS) lipid peroxide accumulation, leading to damage impairments. The intricate interplay between iron, inflammation, oxidative stress SCD underscores the necessity thoroughly understanding these processes for development innovative therapeutic strategies. This review highlights importance balancing complex interactions among various factors exploitation knowledge developing novel therapeutics this devastating disease.

Language: Английский

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Environment-relevant concentrations of cadmium induces necroptosis and inflammation; baicalein maintains gill homeostasis through suppressing ROS/ER stress signaling in common carps (Cyprinus carpio L.)

Environmental Pollution, Journal Year: 2023, Volume and Issue: 340, P. 122805 - 122805

Published: Oct. 30, 2023

Language: Английский

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Computational design of new polymers having low exciton binding energy for organic solar cells fabrication: Chemical generation and visualization

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 450, P. 115457 - 115457

Published: Jan. 4, 2024

Language: Английский

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Role of Mitochondrial Reactive Oxygen Species-Mediated Chaperone-Mediated Autophagy and Lipophagy in Baicalin and N-Acetylcysteine Mitigation of Cadmium-Induced Lipid Accumulation in Liver

Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 115 - 115

Published: Jan. 17, 2024

Cadmium (Cd) is a major health concern globally and can accumulate cause damage in the liver for which there no approved treatment. Baicalin N-acetylcysteine (NAC) have been found to protective effects against variety of injuries, but it not clear whether their combined use effective preventing treating Cd-induced lipid accumulation. The study that Cd increased production mitochondrial reactive oxygen species (mROS) elevated level chaperone-mediated autophagy (CMA). Interestingly, mROS-mediated CMA exacerbates inhibition lipophagy. NAC counteracted lipophagy by attenuating CMA, suggesting an interplay between elevation, destruction, mROS formation. Maintaining stability structure function essential alleviating accumulation liver. Choline component membrane responsible maintaining its function. Mitochondrial transcriptional factor A (TFAM) involved DNA activation replication. Our revealed combination baicalin regulate choline metabolism through TFAM thereby maintain functionality. In summary, plays more beneficial role than drug alone, stabilize inhibit TFAM-choline, promoting alleviate

Language: Английский

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NLRP3 Inflammasome in Atherosclerosis: Putting Out the Fire of Inflammation

Inflammation, Journal Year: 2022, Volume and Issue: 46(1), P. 35 - 46

Published: Aug. 11, 2022

Language: Английский

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