Clinical Kidney Journal,
Journal Year:
2024,
Volume and Issue:
17(6)
Published: April 23, 2024
ABSTRACT
Background
There
is
interest
in
identifying
novel
filtration
markers
that
lead
to
more
accurate
GFR
estimates
than
current
(creatinine
and
cystatin
C)
are
consistent
across
demographic
groups.
We
hypothesize
large-scale
metabolomics
can
identify
serum
metabolites
strongly
influenced
by
glomerular
rate
(GFR)
variables
creatinine,
which
would
be
promising
for
future
investigation.
Methods
evaluated
the
consistency
of
associations
between
measured
(mGFR)
887
common,
known
quantified
an
untargeted
chromatography-
spectroscopy-based
platform
(Metabolon)
performed
on
frozen
blood
samples
from
580
participants
Chronic
Kidney
Disease
Children
(CKiD),
674
Modification
Diet
Renal
(MDRD)
Study
962
African
American
Hypertension
(AASK).
metabolite–mGFR
correlation
association
with
metabolite
class,
molecular
weight,
assay
measurement
coefficient
variation
(CV).
Among
strong
negative
correlations
mGFR
(r
<
−0.5),
we
assessed
additional
age
(height
children),
sex,
race
body
mass
index
(BMI).
Results
A
total
561
(63%)
were
negatively
correlated
mGFR.
Correlations
highly
study,
BMI
categories
(correlation
0.88
0.95).
Amino
acids,
carbohydrates
nucleotides
often
compared
lipids,
but
there
was
no
liquid
chromatography/mass
spectrometry
CV.
114
27
consistently
not
associated
sex
or
race.
Conclusions
The
majority
race,
study.
Metabolites
non-association
may
represent
candidate
improve
estimation
GFR.
The Nephron journals/Nephron journals,
Journal Year:
2023,
Volume and Issue:
148(1), P. 1 - 10
Published: May 15, 2023
<b><i>Background:</i></b>
Due
to
the
complexity
of
chronic
kidney
disease
(CKD)
pathophysiology,
biomarkers
representing
different
mechanistic
pathways
have
been
targeted
for
study
and
development
novel
biomarkers.
The
discovery
clinically
useful
CKD
would
allow
identification
those
children
at
highest
risk
function
decline
timely
interventions
enrollment
in
clinical
trials.
<b><i>Summary:</i></b>
Glomerular
filtration
rate
proteinuria
are
traditional
classify
prognosticate
progression
practice
but
several
limitations.
Over
recent
decades,
identified
from
blood
or
urine
with
metabolomic
screening
studies,
proteomic
an
improved
knowledge
pathophysiology.
This
review
highlights
promising
associated
that
could
potentially
serve
as
future
prognostic
markers
CKD.
<b><i>Key
Messages:</i></b>
Further
studies
needed
validate
putative
biomarkers,
particularly
candidate
proteins
metabolites,
improving
management.
Biomolecules and Biomedicine,
Journal Year:
2024,
Volume and Issue:
24(5), P. 1044 - 1054
Published: March 27, 2024
Pediatric
renal
diseases
encompass
a
diverse
array
of
pathological
conditions,
often
engendering
enduring
ramifications.
Metabolomics,
an
emergent
branch
omics
sciences,
endeavors
to
holistically
delineate
alterations
in
metabolite
compositions
through
the
amalgamation
sophisticated
analytical
chemistry
techniques
and
robust
statistical
methodologies.
Recent
advancements
metabolomics
research
within
realm
pediatric
nephrology
have
been
substantial,
offering
promising
avenues
for
identification
biomarkers,
elaboration
novel
therapeutic
targets,
intricate
elucidation
molecular
mechanisms.
The
present
discourse
aims
critically
review
progress
profiling
pertinent
disorders
over
previous
12
years.
Clinical Journal of the American Society of Nephrology,
Journal Year:
2021,
Volume and Issue:
16(8), P. 1152 - 1154
Published: Aug. 1, 2021
Metabolomics
is
defined
as
the
quantification
of
small
molecules
(usually
<1500
Daltons)
within
a
biologic
specimen
(
e.g.,
plasma)
([1][1]).
Detectable
metabolites
belong
to
various
chemical
classes
like
amino
acids
or
lipids.
Their
concentrations
are
result
interaction
between
genes,
Clinical Kidney Journal,
Journal Year:
2024,
Volume and Issue:
17(6)
Published: April 23, 2024
ABSTRACT
Background
There
is
interest
in
identifying
novel
filtration
markers
that
lead
to
more
accurate
GFR
estimates
than
current
(creatinine
and
cystatin
C)
are
consistent
across
demographic
groups.
We
hypothesize
large-scale
metabolomics
can
identify
serum
metabolites
strongly
influenced
by
glomerular
rate
(GFR)
variables
creatinine,
which
would
be
promising
for
future
investigation.
Methods
evaluated
the
consistency
of
associations
between
measured
(mGFR)
887
common,
known
quantified
an
untargeted
chromatography-
spectroscopy-based
platform
(Metabolon)
performed
on
frozen
blood
samples
from
580
participants
Chronic
Kidney
Disease
Children
(CKiD),
674
Modification
Diet
Renal
(MDRD)
Study
962
African
American
Hypertension
(AASK).
metabolite–mGFR
correlation
association
with
metabolite
class,
molecular
weight,
assay
measurement
coefficient
variation
(CV).
Among
strong
negative
correlations
mGFR
(r
<
−0.5),
we
assessed
additional
age
(height
children),
sex,
race
body
mass
index
(BMI).
Results
A
total
561
(63%)
were
negatively
correlated
mGFR.
Correlations
highly
study,
BMI
categories
(correlation
0.88
0.95).
Amino
acids,
carbohydrates
nucleotides
often
compared
lipids,
but
there
was
no
liquid
chromatography/mass
spectrometry
CV.
114
27
consistently
not
associated
sex
or
race.
Conclusions
The
majority
race,
study.
Metabolites
non-association
may
represent
candidate
improve
estimation
GFR.
