COVID‐19 and cancer: Dichotomy of the menacing dilemma DOI Creative Commons
Mrinal K. Ghosh,

Shaheda Tabassum,

Malini Basu

et al.

MedComm – Oncology, Journal Year: 2023, Volume and Issue: 2(4)

Published: Nov. 30, 2023

Abstract The coronavirus disease 2019 (COVID‐19) pandemic brought about unprecedented challenges to global healthcare systems. Among the most vulnerable populations are cancer patients, who face dilemmas due their compromised immune systems and intricate interplay with severe acute respiratory syndrome 2 (SARS‐CoV‐2) virus. This comprehensive review delves into multifaceted relationship between COVID‐19 cancer. Through an analysis of existing literature clinical data, this unravels structural intricacies virus examines its profound implications for thereby bridging knowledge gap virology oncology. commences introduction regarding It then transitions a detailed examination SARS‐CoV‐2 variants such as Alpha (PANGO lineage B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), Omicron (B.1.1.529 lineage). Subsequently, insightful impact on major types (viz., Lung, Colon, Brain, gastrointestinal cancer) is elaborated. Finally, therapeutic avenues, oncological care, management discussed. nexus adds layer complexity patient emphasizing importance tailored approaches those grappling both conditions. Amid landscape defined by evolving viral strains, navigates through patients underscores significance integrating

Language: Английский

GBM immunotherapy: Exploring molecular and clinical frontiers DOI
Mrinal K. Ghosh,

Sunny Kumar,

Sabana Begam

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 356, P. 123018 - 123018

Published: Aug. 28, 2024

Language: Английский

Citations

6
Synthesis of Cobalt(III) Complexes Derived from Pyridoxal: Structural Cleavage Evaluations and In Silico Calculations for Biological Targets DOI Creative Commons

Liniquer A. Fontana,

Francisco Mainardi Martins, Josiéli Demetrio Siqueira

et al.

Inorganics, Journal Year: 2024, Volume and Issue: 12(6), P. 171 - 171

Published: June 18, 2024

This study sought to investigate the synthesis of eight complexes constituted by a cobalt(III) (CoIII) metallic center coordinated two units iminic ligands LnC (n = 1–4, L1C–L4C), which are derivatives pyridoxal hydrochloride and anilines with thioether function containing one four carbons. Depending on source cobalt ion addition (or not) non-coordinating counterion, distinct structures may form, being categorized into series: [CoIII(LnC)(L0C)] C1’–C4’) ligand that has thiolate cleaves C-S(thioether) bond (L0C) [CoIII(LnC)2]PF6 C1–C4) similar same ligand. The occurrence cleavage in was observed elucidating solid-state single crystal X-ray diffraction. exciting method allows CoIII without cleaving C-S bonds from ligands, thereby not requiring an inert atmosphere reaction systems. synthesized were evaluated silico calculations viable biological targets such as deoxyribonucleic acid, superoxide dismutase enzyme, human serum albumin, structural spike glycoprotein severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) both up down conformations complex cellular angiotensin-converting enzyme (ACE2). Overall, results suggested all inorganic under potential anticancer/antiviral agents; however, C4 C4’ best candidates for future vitro assays.

Language: Английский

Citations

2
E3 ubiquitin ligases and deubiquitinases in colorectal cancer: Emerging molecular insights and therapeutic opportunities DOI
Sunny Kumar, Malini Basu, Mrinal K. Ghosh

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2024, Volume and Issue: 1871(8), P. 119827 - 119827

Published: Aug. 24, 2024

Language: Английский

Citations

1
COVID-19 and Carcinogenesis: Exploring the Hidden Links DOI Open Access
Özgür Tanrıverdi, Ali Alkan,

Turan Karaoglu

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

The COVID-19 pandemic caused by the SARS-CoV-2 virus has been studied predominantly in terms of its immediate respiratory and systemic effects. However, emerging evidence suggests possible long-term effects, including role carcinogenesis. This comprehensive review explores complex relationship between cancer development, focusing on immune dysregulation, chronic inflammation, genetic epigenetic alterations, impact therapeutic interventions. We also focused molecular mechanisms which may facilitate progression, roles angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease (TMPRSS2), FURIN. Additionally, we examined carcinogenic effects treatments interaction co-infections risk. Our findings highlight need for increased surveillance survivors. In post-COVID-19 period, it can be thought that inflammation associated with excessive cytokine release, especially interleukin-6, changes, oncogenic viruses such as Epstein-Barr or human papillomavirus effective development progression cancer. Further research is needed to explain underlying this relationship.

Language: Английский

Citations

1
Carbon Nanotubes in Cancer Diagnosis and Treatment: Current Trends and Future Perspectives DOI

Sunny Kumar,

Aafreen Ansari, Malini Basu

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Carbon nanotubes (CNTs) have emerged as revolutionary tools, offering innovative approaches to both diagnostic and therapeutic challenges spanning various cancer types. CNTs serve imaging agents for early detection through MRI, CT, fluorescence. They provide precise results with biosensors detecting biomarkers rapid diagnosis. In therapy, excel in targeted drug delivery, enhancing bioavailability minimizing off‐target effects. Their prowess photothermal therapy selectively eradicates cells. Despite challenges, ongoing research highlights CNT's transformative potential, promising enhanced precision, efficacy, personalized care across diverse malignancies future clinical practice.

Language: Английский

Citations

1
Impact of the COVID-19 Pandemic on Tumor Stage and Pathohistological Parameters of Vulvar Cancer DOI Open Access
Gilbert Georg Klamminger,

Annick Bitterlich,

Meletios P. Nigdelis

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4058 - 4058

Published: July 11, 2024

Background/Objectives: Vulvar cancer (VC) comprises a small fraction of female neoplasms with notable high-incidence clusters among German regions. Despite proposed impact nationwide lockdowns in response to the COVID-19 pandemic on oncological diseases, effect VC staging and tumor characteristics remains yet be resolved; therefore, analyzing pathological data from patients squamous cell pre-, during, post-COVID region may offer insights into potential epidemiological clinical trends. Methods: We identified total 90 who were diagnosed at Institute Pathology, University Hospital Saarland, between 2018 2023, defined three distinct cohorts: pre-COVID cohort (2018-2019), COVID (2020-2021), (2022-2023). Histomorphological collected individual patient reports statistically analyzed using Fisher's exact test or Kruskal-Wallis test. Results: Although we found no significant differences age, T-stage, perineural infiltration, blood vessel resection status, grading, margin our cohorts, surprisingly, determined greater extent lymphovascular infiltration (Fisher's test; p = 0.041), as well deeper depth (Kruskal-Wallis < 0.001) before pandemic. Furthermore, did not identify any soft indications abnormalities care within center (unchanged status margins across all cohorts). Conclusions: Our results clearly do support negative affection pathobiological during after However, final assessments regarding pandemic's require additional study approaches various regions, preferably future extended timeframes longer follow-up.

Language: Английский

Citations

0
COVID‐19 and cancer: Dichotomy of the menacing dilemma DOI Creative Commons
Mrinal K. Ghosh,

Shaheda Tabassum,

Malini Basu

et al.

MedComm – Oncology, Journal Year: 2023, Volume and Issue: 2(4)

Published: Nov. 30, 2023

Abstract The coronavirus disease 2019 (COVID‐19) pandemic brought about unprecedented challenges to global healthcare systems. Among the most vulnerable populations are cancer patients, who face dilemmas due their compromised immune systems and intricate interplay with severe acute respiratory syndrome 2 (SARS‐CoV‐2) virus. This comprehensive review delves into multifaceted relationship between COVID‐19 cancer. Through an analysis of existing literature clinical data, this unravels structural intricacies virus examines its profound implications for thereby bridging knowledge gap virology oncology. commences introduction regarding It then transitions a detailed examination SARS‐CoV‐2 variants such as Alpha (PANGO lineage B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), Omicron (B.1.1.529 lineage). Subsequently, insightful impact on major types (viz., Lung, Colon, Brain, gastrointestinal cancer) is elaborated. Finally, therapeutic avenues, oncological care, management discussed. nexus adds layer complexity patient emphasizing importance tailored approaches those grappling both conditions. Amid landscape defined by evolving viral strains, navigates through patients underscores significance integrating

Language: Английский

Citations

0