Glutathione S-Transferases: Potential Implications in Parkinson's Disease. DOI Open Access
Sonia Verma,

Pratyush Padhan,

Simran Simran

et al.

Published: Aug. 8, 2024

Parkinson's disease is a progressive neurodegenerative disorder that predominantly affects motor function due to the loss of dopaminergic neurons in substantia nigra. It presents significant challenges, impacting millions worldwide with symptoms such as tremors, rigidity, bradykinesia, and postural instability, leading decreased quality life increased morbidity. The pathogenesis multifaceted, involving complex interactions between genetic susceptibility, environmental factors, aging, oxidative stress playing central role neuronal degeneration. Glutathione S-Transferase enzymes are critical cellular defense mechanism against stress, catalyzing conjugation antioxidant glutathione various toxic compounds, thereby facilitating their detoxification. Recent research underscores importance pathophysiology disease, revealing polymorphisms genes influence risk progression disease. These variations can affect enzymatic activity S-Transferase, modulating an individual's capacity detoxify reactive oxygen species xenobiotics, which implicated neuropathological processes. Moreover, biochemical studies have elucidated not only maintaining redox balance but also signalling pathways, highlighting its neuroprotective potential. From therapeutic perspective, targeting pathways offers promising avenues for development novel treatments aimed at enhancing neuroprotection mitigating progression. This review explores evident hypothesized roles providing comprehensive overview potential target intervention.

Language: Английский

SLEEP DISORDERS AND RISK OF ALZHEIMER'S DISEASE: A TWO-WAY ROAD DOI

Rafael Antônio Vicente Lacerda,

Janaína Aparecida Favero Desio, Camila Marciele Kammers

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102514 - 102514

Published: Sept. 1, 2024

Language: Английский

Citations

4
The Promise of Epigenetic Editing for Treating Brain Disorders DOI
Luis Alfonso González-Molina, Amalia M. Dolga, Marianne G. Rots

et al.

Sub-cellular biochemistry/Subcellular biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 111 - 190

Published: Jan. 1, 2025

Language: Английский

Citations

0
Values of epigenetic markers in Parkinson's disease as biomarkers and therapeutic targets: A narrative review DOI Creative Commons
Dhruv Parikh, Manan Shah

NeuroMarkers., Journal Year: 2025, Volume and Issue: unknown, P. 100037 - 100037

Published: Feb. 1, 2025

Language: Английский

Citations

0
Acetylation and deacetylation dynamics in stress response to cancer and infections DOI

Lili Li,

Yanqiong Zeng,

Genhong Cheng

et al.

Seminars in Immunology, Journal Year: 2025, Volume and Issue: 78, P. 101957 - 101957

Published: April 26, 2025

Language: Английский

Citations

0
Biomarkers of cognitive and memory decline in psychotropic drug users DOI Creative Commons
Monica Grigore, Mihai Andrei Ruscu, Dirk M. Hermann

et al.

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Psychotropic drugs are vital in psychiatry, aiding the management of mental health disorders. Their use requires an understanding their pharmacological properties, therapeutic applications, and potential side effects. Ongoing research aims to improve efficacy safety. Biomarkers play a crucial role predicting memory decline psychotropic drug users. A comprehensive biomarkers, including neuroimaging, biochemical, genetic, cognitive assessments, is essential for developing targeted interventions preventive strategies. In this narrative review, we performed search on PubMed Google using review-specific terms. Clinicians should multifaceted approach, neurotransmitter analysis, neurotrophic factors, miRNA profiling, tasks early intervention personalized treatment. Anxiolytics' mechanisms involve various systems emerging targets. Research biomarkers anxiolytic users can lead detection intervention, enhancing clinical practices aligning with precision medicine. Mood stabilizer benefit from through RNA, neurophysiological, inflammatory promoting timely interventions. Performance-enhancing may boost athletic performance short term, but long-term risks ethical issues make problematic. Long-term enhancers athletes shows changes decline, necessitating ongoing monitoring Understanding these genetic influences helps pave way approaches prevent or mitigate deterioration, emphasizing importance screening based individual's profile. Future focus refining protective measures against deterioration. Overall,

Language: Английский

Citations

1
Glutathione S-transferase: A keystone in Parkinson's disease pathogenesis and therapy DOI

Pratyush Padhan,

Simran Simran,

Neeraj Kumar

et al.

Molecular and Cellular Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 103981 - 103981

Published: Dec. 1, 2024

Language: Английский

Citations

1
Epigenetics of cerebrovascular diseases: an update review of clinical studies DOI
Anna Maria Ciaccio, Antonino Tuttolomondo

Epigenomics, Journal Year: 2024, Volume and Issue: 16(14), P. 1043 - 1055

Published: July 17, 2024

Cerebrovascular diseases, especially stroke, are critical and heterogenous clinical conditions associated with high mortality chronic disability. Genome-wide association studies reveal substantial stroke heritability, though specific genetic variants account for a minor fraction of risk, suggesting an essential role the epigenome. Epigenome-wide candidate gene approaches show that DNA methylation patterns significantly influence susceptibility. Additionally, chromatin remodelers non-coding RNA regulate expression in response to ischemic conditions. In this updated review, we summarized progress knowledge on epigenetics field underlying opportunities challenges.

Language: Английский

Citations

0
Glutathione S-Transferases: Potential Implications in Parkinson's Disease. DOI Open Access
Sonia Verma,

Pratyush Padhan,

Simran Simran

et al.

Published: Aug. 8, 2024

Parkinson's disease is a progressive neurodegenerative disorder that predominantly affects motor function due to the loss of dopaminergic neurons in substantia nigra. It presents significant challenges, impacting millions worldwide with symptoms such as tremors, rigidity, bradykinesia, and postural instability, leading decreased quality life increased morbidity. The pathogenesis multifaceted, involving complex interactions between genetic susceptibility, environmental factors, aging, oxidative stress playing central role neuronal degeneration. Glutathione S-Transferase enzymes are critical cellular defense mechanism against stress, catalyzing conjugation antioxidant glutathione various toxic compounds, thereby facilitating their detoxification. Recent research underscores importance pathophysiology disease, revealing polymorphisms genes influence risk progression disease. These variations can affect enzymatic activity S-Transferase, modulating an individual's capacity detoxify reactive oxygen species xenobiotics, which implicated neuropathological processes. Moreover, biochemical studies have elucidated not only maintaining redox balance but also signalling pathways, highlighting its neuroprotective potential. From therapeutic perspective, targeting pathways offers promising avenues for development novel treatments aimed at enhancing neuroprotection mitigating progression. This review explores evident hypothesized roles providing comprehensive overview potential target intervention.

Language: Английский

Citations

0