Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
169, P. 115839 - 115839
Published: Nov. 16, 2023
Copper-induced
cell
death,
also
known
as
cuproptosis,
is
distinct
from
other
types
of
death
such
apoptosis,
necrosis,
and
ferroptosis.
It
can
trigger
the
accumulation
lethal
reactive
oxygen
species,
leading
to
onset
progression
aging.
The
significant
increases
in
copper
ion
levels
aging
populations
confirm
a
close
relationship
between
homeostasis
vascular
On
hand,
closely
related
occurrence
various
cardiovascular
diseases
throughout
process.
However,
specific
causes
are
not
clear,
different
living
environments
stress
patterns
lead
individualized
By
exploring
correlations
copper-induced
aging,
we
gain
novel
perspective
on
pathogenesis
enhance
prognosis
atherosclerosis.
This
article
aims
provide
comprehensive
review
impacts
including
their
effects
endothelial
cells,
smooth
muscle
oxidative
stress,
ferroptosis,
intestinal
flora,
factors.
Furthermore,
intend
discuss
potential
strategies
involving
cuproptosis
new
insights
for
copper-related
Abstract
Cuproptosis,
the
current
form
of
regulated
cell
death
characterized
by
copper
overload,
oligomerization
lipoacylated
proteins,
and
loss
Fe–S
cluster
has
been
proposed
to
function
closely
with
human
diseases,
including
cancer.
Since
its
first
identification
in
2022,
many
strategies
have
developed
induce
cuproptosis
for
cancer
therapy,
such
as
small‐molecule
drugs
nanomaterials.
Although
reviews
related
reported,
they
remain
at
a
basic
mechanism
level,
summary
covering
recent
progress
field
nanotechnologies
cuproptosis‐based
therapy
not
yet
presented.
Therefore,
it
is
time
fill
gap
shed
light
on
future
directions
application
this
promising
tool
fight
against
In
minireview,
we
expounded
action
emphasized
feasibility
triggering
therapy.
The
treatments
based
nanoparticle‐induced
was
then
described.
Finally,
challenges
development
emerging
are
also
discussed.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 6, 2023
In
the
quest
for
cancer
treatment
modalities
with
greater
effectiveness,
combination
of
tumor
immunotherapy
and
nanoparticle-based
hyperthermia
has
emerged
as
a
promising
frontier.
The
present
article
provides
comprehensive
review
recent
advances
cutting-edge
research
in
this
burgeoning
field
examines
how
these
two
strategies
can
be
effectively
integrated.
Tumor
immunotherapy,
which
harnesses
immune
system
to
recognize
attack
cells,
shown
considerable
promise.
Concurrently,
hyperthermia,
utilizes
nanotechnology
promote
selective
cell
death
by
raising
temperature
an
innovative
therapeutic
approach.
While
both
have
individually
potential,
may
amplify
anti-tumor
responses,
improved
outcomes
reduced
side
effects.
Key
studies
illustrating
synergistic
effects
approaches
are
highlighted,
current
challenges
future
prospects
discussed.
As
we
stand
on
precipice
new
era
treatment,
underscores
importance
continued
collaboration
bringing
treatments
from
bench
bedside.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
169, P. 115839 - 115839
Published: Nov. 16, 2023
Copper-induced
cell
death,
also
known
as
cuproptosis,
is
distinct
from
other
types
of
death
such
apoptosis,
necrosis,
and
ferroptosis.
It
can
trigger
the
accumulation
lethal
reactive
oxygen
species,
leading
to
onset
progression
aging.
The
significant
increases
in
copper
ion
levels
aging
populations
confirm
a
close
relationship
between
homeostasis
vascular
On
hand,
closely
related
occurrence
various
cardiovascular
diseases
throughout
process.
However,
specific
causes
are
not
clear,
different
living
environments
stress
patterns
lead
individualized
By
exploring
correlations
copper-induced
aging,
we
gain
novel
perspective
on
pathogenesis
enhance
prognosis
atherosclerosis.
This
article
aims
provide
comprehensive
review
impacts
including
their
effects
endothelial
cells,
smooth
muscle
oxidative
stress,
ferroptosis,
intestinal
flora,
factors.
Furthermore,
intend
discuss
potential
strategies
involving
cuproptosis
new
insights
for
copper-related
