Medicine,
Journal Year:
2024,
Volume and Issue:
103(12), P. e37502 - e37502
Published: March 22, 2024
The
incidence
of
long
COVID
in
adult
survivors
an
acute
SARS-CoV-2
infection
is
approximately
11%.
Of
those
afflicted,
26%
have
difficulty
with
day-to-day
activities.
majority
COIVD
cases
occur
after
mild
or
asymptomatic
infection.
Children
can
spread
infections
and
also
develop
long-term
neurological,
endocrine
(type
I
diabetes),
immunological
sequelae.
Immunological
hypofunction
exemplified
by
the
recent
large
outbreaks
respiratory
syncytial
virus
streptococcal
infections.
Neurological
manifestations
are
associated
anatomical
brain
damage
demonstrated
on
scans
autopsy
studies.
prefrontal
cortex
particularly
susceptible.
Common
symptoms
include
fog,
memory
loss,
executive
dysfunction,
personality
changes.
impact
society
has
been
profound.
Fewer
than
half
previously
employed
adults
who
working
full-time,
42%
patients
reported
food
insecurity
20%
difficulties
paying
rent.
Vaccination
not
only
helps
prevent
severe
COVID-19,
but
numerous
studies
found
beneficial
effects
preventing
mitigating
COVID.
There
evidence
that
vaccination
lessen
Physical
occupational
therapy
help
regain
function,
approach
must
be
"low
slow."
Too
much
physical
mental
activity
result
post-exertional
malaise
set
back
recovery
process
days
weeks.
complexity
presentations
coupled
rampant
organized
disinformation,
caused
significant
segments
public
to
ignore
sound
health
advice.
Further
research
needed
regarding
treatment
effective
communication.
Human Vaccines & Immunotherapeutics,
Journal Year:
2025,
Volume and Issue:
21(1)
Published: March 13, 2025
This
systematic
literature
review
summarizes
the
evidence
across
56
publications
and
pre-prints
(January
2020–July
2023)
with
low-risk
of
bias
based
on
JBI
critical
appraisal,
that
report
adjusted
estimates
for
relationship
between
COVID-19
vaccination
Post-COVID-19
Condition
(PCC)
by
timing
relative
to
infection
or
PCC-onset.
Comparisons
vaccine
effectiveness
(aVE)
against
≥1
PCC
(vs.
unvaccinated)
study
characteristics
known
impact
burden
VE
other
endpoints
were
possible
31
studies
where
preceded
infection.
Seventy-seven
percent
pre-infection
aVE
statistically
significant
(range:
7%–95%).
Statistically
slightly
higher
mRNA
14%–84%)
than
non-mRNA
vaccines
16%–38%)
ranges
before
during
Omicron
overlapped.
Our
findings
suggest
SARS-CoV-2
reduces
risk
regardless
type,
number
doses
received,
definition,
predominant
variant,
severity
acute
infections
included.
Clinical Case Reports,
Journal Year:
2025,
Volume and Issue:
13(4)
Published: April 1, 2025
ABSTRACT
Fulminant
type
1
diabetes
is
a
rare
but
severe
condition
that
can
develop
rapidly,
often
in
association
with
viral
infections.
In
this
case,
coxsackievirus
B6
antibody
levels
were
elevated
after
disease
onset,
though
its
significance
remains
unclear.
This
highlights
the
importance
of
thorough
screening
fulminant
and
need
for
further
research
to
better
understand
potential
contributing
factors,
including
post‐vaccination
contexts.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(5), P. e0321897 - e0321897
Published: May 2, 2025
Background
The
COVID-19
pandemic
has
led
to
an
alarming
increase
in
mucormycosis
coinfections
and
its
rapid
progression.
overlapping
risk
factors
symptoms
between
further
complicate
prompt
detection,
which
is
crucial
for
patient
survival.
This
study
aims
investigate
potential
differences
progression,
initial
symptom
presentation,
laboratory
value
alterations
patients
with
history
enhance
diagnostic
accuracy
improve
outcomes
this
complex
clinical
scenario.
Methodology
retrospective
cohort
study,
conducted
from
April
1,
2021,
March
31,
2022,
examined
102
diagnosed
at
two
primary
teaching
hospitals.
Patients
were
categorized
into
groups
based
on
history.
Variables
included
demographic
information,
parameters,
results,
outcomes.
compared
studies
presentation
history-positive
history-negative
groups,
a
particular
focus
mortality
rates
associated
comorbidities
such
as
diabetes,
cancer
immunosuppressive
treatment.
Results
Initial
presentations
differed
significantly,
eneralized
Estimating
Equations
(GEE)
analysis,
adjusted
comorbidities,
revealed
was
increased
platelet
counts
(P
=
0.0311)
decreased
facial
swelling
0.049)
fever
reporting
<
0.001).
Cancer
history,
treatment
also
showed
significant
associations
various
parameters.
Laboratory
analysis
without
group
lower
WBC
0.002),
higher
hemoglobin
levels
0.001)
controls.
Diabetes
more
prevalent
patients,
while
common
Conclusion
reveals
intricate
relationships
mucormycosis,
challenging
earlier
findings.
Mucormycosis
exhibited
altered
presentation.
research
highlights
varied
patterns
across
subgroups
underscores
the
complexity
of
interactions
COVID-19,
cancer,
diabetes
cases.
These
findings
advocate
multivariate
analytical
approaches
better
understand
these
multifaceted
relationships.
Journal of Medical Virology,
Journal Year:
2024,
Volume and Issue:
96(5)
Published: May 1, 2024
The
effects
of
COVID-19
vaccination
on
short-term
and
long-term
cerebrovascular
risks
among
survivors
remained
unknown.
We
conducted
a
national
multi-center
retrospective
cohort
study
with
151
597
vaccinated
unvaccinated
patients
using
the
TriNetX
database,
from
January
1,
2020
to
December
31,
2023.
Patients
baseline
characteristics
were
balanced
propensity
score
matching
(PSM).
outcomes
incident
diseases
occurred
between
1st
30th
days
(short-term)
after
diagnosis.
Nine
subgroup
analyses
explore
potential
effect
modifications.
performed
six
sensitivity
analyses,
including
evaluation
180th
days,
accounting
for
competing
risk,
incorporating
different
variant
timeline
test
robustness
our
results.
Kaplan-Meier
curves
Log-Rank
tests
evaluate
survival
difference.
Cox
proportional
hazards
regressions
adopted
estimate
PSM-adjusted
hazard
ratios
(HR).
overall
lower
in
group
compared
(HR:
0.66,
95%
CI:
0.56-0.77),
specifically
cerebral
infarction
0.62,
0.48-0.79),
occlusion
stenosis
precerebral
arteries
0.74,
0.53-0.98),
other
0.57,
0.42-0.77),
sequelae
disease
0.39,
CI:0.23-0.68).
Similarly,
those
most
subgroups.
outcomes,
though
slightly
attenuated,
consistent
0.80,
0.73-0.87).
Full
2-dose
was
associated
further
reduced
risk
0.63,
0.50-0.80)
patients.
Unvaccinated
have
significantly
higher
than
their
counterparts.
Thus,
clinicians
are
recommended
monitor
this
population
closely
stroke
events
during
postinfection
follow-up.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 4, 2024
Abstract
Importance
Existing
systematic
literature
reviews
(SLRs)
on
COVID-19
vaccine
effectiveness
(VE)
against
post-COVID-19
conditions
(PCC)
document
high
heterogeneity
across
studies,
but
have
not
compared
VE
design
features
known
to
impact
PCC
burden
or
other
endpoints.
Objective
This
SLR
summarizes
the
evidence
studies
among
predominately
adults
that
report
an
adjusted
measure
of
association
for
relationship
between
vaccination
and
PCC,
by
timing
relative
infection
PCC-onset
different
study
characteristics.
Evidence
review
A
comprehensive
search
strategy
was
developed
within
OVID
platform
EMBASE,
MEDLINE®
Evidence-Based
Medicine
reviews,
supplemented
with
WHO
COVID
library
Google
Scholar®
searches,
collate
published
posted
as
pre-prints
January
1
st
,
2020
July
18
th
2023.
JBI
Critical
Appraisal
Checklists
were
used
assess
each
study’s
risk
bias.
Findings
included
97
synthesized
results
from
56
low
bias
reported
measures
PCC.
Overall,
77%
pre-infection
(aVE)
estimates
(vs.
unvaccinated)
statistically
significant
(range:
7%–95%),
80%
reflecting
a
mix
those
vaccinated
before
after
62%–73%),
one
five
onset
(aVE=41%),
43%
post-infection
(two
protective
[range:
28%–40%]
[aVE=-47%]),
46%
specifying
(23
29%–75%]
[aVE=-132%]).
Statistically
aVE
slightly
higher
mRNA
14%–84%)
than
non-mRNA
vaccines
16%–38%)
ranges
during
(4
studies;
range:
10%–70%)
Omicron
predominance
(10
7%–50%)
overlapped.
Pre-infection
regardless
type,
number
doses
received,
definition,
predominant
variant,
severity
acute
infections
included.
Conclusions
Relevance
Collectively
our
findings
suggest
received
prior
SARS-CoV-2
reduces
subsequent
developing
variant
circulating.
Key
points
Question
Do
vary
onset,
type
disease
severity?
appeared
reduce
unvaccinated).
Compared
types,
seemed
offer
greater
protection,
dose
response
observed
vaccines.
Meaning
Despite
reduced
≥1
proportion
sample
hospitalized,
definition.
