How Do the Timing of Early Rehabilitation Together with Cognitive and Functional Variables Influence Stroke Recovery? Results from the CogniReMo Italian Multicentric Study

Healthcare, Journal Year: 2025, Volume and Issue: 13(3), P. 316 - 316

Published: Feb. 4, 2025

Background: The time lapse between the acute event and beginning of rehabilitation seems to play a significant role in determining effectiveness together with severity neurological deficits impairments motor cognitive functions. present study aims further explore prognostic functions, concerning different times neurorehabilitation. Methods: A secondary examination was conducted by applying cluster analysis on data 386 stroke patients subacute phase who were enrolled Cognitive Recovery Motor Functions (CogniReMo) study. Results: Barthel Index at admission predicts clinical outcome: if BI 0, it average 28.7 ± 24.1 discharge. For <15 discharge, discriminant unaltered executive functions having an output 61.3 instead 45.5. In range 16 45, variable have NIHSS ≤ 5 obtain high outcome (BI = 75.4 61.9). Subjects >45 best responders rehabilitation, mean discharge 85 they alteration spatial attention, 95.3 no attention. Also, for inpatients hospitalized period ranging from 20th 37th day after stroke, attention poor 34.3) vs. good one 76.7). Conclusions: algorithm identified hierarchical decision tree that might assume clinicians defining appropriate pathway, depending deficits.

Language: Английский

---

Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 547 - 547

Published: April 8, 2025

Background: Manganese porphyrin, MnTnBuOE-2-PyP5+ (BMX-001), improves neurologic deficits in experimental ischemic stroke and has the potential to serve as an adjunct with thrombolysis or thrombectomy patients. In 10–30% of patients following thrombolysis, hemorrhagic transformation, associated iron release, occurs. This study aimed examine outcome BMX-001 treatment a mouse intracerebral hemorrhage (ICH) model relevance prospective clinical trials. Methods: Twenty C57Bl6 mice were randomly assigned groups after surgery received vehicle immediately stereotaxic left striatum collagenase injection. Post-ICH body weight, Corner test, neurological deficit score, Rotarod test examined. Six sham control group. At 72 h, brain histological evaluation was performed, including size, Prussian blue staining, activation macrophages. Data collected by researcher who blind groups. Results: No significant difference deficits, size found between However, reduced number macrophages area (48 ± 10 vehicle, 33 8 BMX-001, p = 0.008) cells stained blue—an indicator released during (65 22 41 15 0.027). Conclusions: The results support safe use combination and, moreover, indicate beneficial anti-inflammatory effect alike that previously reported studies analogous, similarly redox-active, Mn porphyrins.

Language: Английский

---

Repetitive transcranial magnetic stimulation in conjunction with scalp acupuncture in treating poststroke cognitive impairment: a protocol for systematic review and meta-analysis

BMJ Open, Journal Year: 2025, Volume and Issue: 15(5), P. e098535 - e098535

Published: May 1, 2025

Introduction Approximately 70% of patients with stroke experience varying degrees cognitive impairment, which imposes a substantial direct and indirect socioeconomic burden. Previous studies have shown that scalp acupuncture (SA) or repetitive transcranial magnetic stimulation (rTMS) in combination other therapies is effective for poststroke impairment (PSCI). Limited by interstudy heterogeneity the limited number included studies, there insufficient evidence efficacy rTMS SA treating PSCI. Therefore, this protocol aims to investigate effectiveness conjunction PSCI through comprehensive meta-analysis. Methods analysis This study will undertake search across nine distinct databases (Web Science, Embase, Cochrane Library, PubMed, China National Knowledge Infrastructure, Wanfang Data, Science Technology Journal Database, Biology Medicine SCOPUS). The primary outcome encompass Montreal Cognitive Assessment Mini-Mental State Examination. secondary outcomes are modified Barthel Index, Rivermead Behavioral Memory Test Digit Span Test. bias risk assessment tool from Handbook Systematic Reviews Interventions be used evaluate risk, GRADE applied gauge quality evidence. Furthermore, we plan perform an subgroups heterogeneity, employ leave-one-out approach sensitivity evaluation use funnel plots Egger’s test determine publication bias, respectively. Ethics dissemination Ethical approval not required systematic review published peer-reviewed journal. PROSPERO registration CRD42024571762.

Language: Английский

---

Michelangelo Effect in Cognitive Rehabilitation: Using Art in a Digital Visuospatial Memory Task

Published: April 16, 2024

Previous studies reported a reduction of the perceived effort and an improvement perfor-mances healthy subjects patients when motor task was combined with artistic images respect to non-artistic images. This phenomenon, called Michelangelo effect, could contribute efficacy art therapy in neurorehabilitation. In this study, possible occurrence effect tested cognitive by asking 15 17 stroke solve digital version classical memory card game. Three different types were used randomized order: French cards, portraits, photos famous people (to compensate effects face recognition). Healthy involved test usability load demanding developed system, reporting no statistically significant differences among three sessions (p &gt; 0.05). Conversely, had better performance terms time = 0.014) number trials 0.007) needed complete presence stimuli, accompanied 0.033). Furthermore, other two images, seemed more associated visuo-spatial control than linguistic functions.

Language: Английский

---

Investigating cognitive impairment, biopsychosocial barriers, and predictors of return to daily life among older stroke survivors

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: June 26, 2024

Purpose The aim was to investigate the associations between cognitive impairment and biopsychosocial factors among older stroke survivors predictors of poststroke return daily life. Materials methods This cross-sectional study involved 117 (61% men) with an average age 77 years (range 65–91). participants completed two questionnaires (Riksstroke Short Form 36 questionnaires). Montreal Cognitive Assessment (MoCA) used assess abilities. International Classification Functioning, Disability, Health (ICF) framework guided selection variables. We Spearman’s correlation coefficient multiple logistic regression in analyses. Results MoCA score 21.7 points (range: 4–30, SD 5.6). need for assistance from relatives professionals, help dressing household chores, reliance on others mobility, reading balance problems were correlated more severe ( r = 0.20–0.33). impairment, fatigue, issues predicted unfavorable life (odds ratio: 6.2–6.8). Conclusion indicated that is associated difficulties all ICF domains. are unsuccessful Prioritizing these screening objective assessment tools may improve rehabilitation outcomes enhance overall quality poststroke.

Language: Английский

---

Cognitive assessment to optimize prediction of functional outcome in subacute hip fracture: a short-term prospective study

European Journal of Physical and Rehabilitation Medicine, Journal Year: 2024, Volume and Issue: 60(2)

Published: March 14, 2024

Cognitive impairment is a long-known negative prognostic factor after hip fracture. Cognition usually screened by single easy-to-administer bedside tool, but recent studies have shown that screening tests may be not enough to rule out cognitive with an unfavorable role. Unfortunately, data on outcome prediction further assessments sparse.

Language: Английский

---

Michelangelo Effect in Cognitive Rehabilitation: Using Art in a Digital Visuospatial Memory Task

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(5), P. 479 - 479

Published: May 9, 2024

The Michelangelo effect is a phenomenon that shows reduction in perceived effort and an improvement performance among both healthy subjects patients when completing motor task related to artistic stimuli, compared performing the same with non-artistic stimuli. It could contribute efficacy of art therapy neurorehabilitation. In this study, possible occurrence was tested cognitive by asking 15 17 history stroke solve digital version classical memory card game. Three different types images were used randomized order: French cards, portraits, photos famous people (to compensate for effects face recognition). Healthy involved test usability load demand developed system, reporting no statistically significant differences three sessions (p > 0.05). Conversely, had better terms time = 0.014) number attempts 0.007) needed complete presence accompanied 0.033). Furthermore, respect other two images, seemed more associated visuospatial control than linguistic functions.

Language: Английский

---

Application of Multidomain Cognitive Training in a Tele-Neurorehabilitation Setting for Treatment of Post-Stroke Cognitive Disorders

Brain Sciences, Journal Year: 2024, Volume and Issue: 15(1), P. 11 - 11

Published: Dec. 26, 2024

Cognitive dysfunctions are still very common in the chronic phase of stroke when patients discharged from neurorehabilitation centers. Even individuals who appear to have made a full clinical recovery may exhibit new deficiencies at home. Here, we present evidence novel kind therapy home aimed contrasting heterogenic evolution using multidomain cognitive approach. Eighteen ischemic were assessed within-subject longitudinal design (age 62.33 ± 11.1 years; eight men). Patients underwent Tele-NeuroRehabilitation (TNR) training treatment Virtual Reality Rehabilitation System (VRRS) five times week for 1 h sessions four consecutive weeks. The protocol included stimulation specific functions, such as logical skills, praxis attention, executive memory, space time orientation and perception, speech therapy. To determine neuropsychological changes, evaluated before (T0), end (T1), after six months (T2). induced significant improvement working memory language abilities well depression symptoms alleviated caregiver burden. Most this enhancement persisted (T2), with exception symptoms. Otherwise, decline attention was reported, thus demonstrating lack effect function. Our results suggest that TNR is suitable reducing some behavioral alterations strokes, beneficial impact also on caregivers' burden distress management. Further RCTs warranted validate

Language: Английский

---

The Future of Neurorehabilitation: Putting the Brain and Body Together Again

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(12), P. 1617 - 1617

Published: Nov. 22, 2023

The neurorehabilitation of cerebrovascular diseases is a challenging scientific topic that has rapidly grown in recent decades [...].

Language: Английский

---

Cognitive Deficits After Stroke: An Overview of Different Cognitive Domains and Its Impact on Functional Outcomes

Published: Jan. 1, 2024

Language: Английский

---