Recent advances in the multicomponent synthesis of heterocycles using tetronic acid

RSC Advances, Journal Year: 2023, Volume and Issue: 13(24), P. 16619 - 16629

Published: Jan. 1, 2023

Tetronic acid, a versatile synthon, has been extensively investigated by numerous researchers in synthetic chemistry due to its crucial role synthesizing heterocycles which makes this compound particularly advantageous both pharmaceutical and biological fields.

Language: Английский

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Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(8)

Published: July 20, 2023

Abstract In terms of pharmaceuticals and biological applications, synthesis complex organic molecules is a significant fast‐developing area. this context, electrosynthesis an alternative way to the traditional methods for chemo‐, regio‐, stereoselective syntheses. Electro‐organic reactions occur at room temperature normal pressure, through transferring electrons. It has been found that mild approach preparing electrophilic substrates, bases, nucleophiles in situ , from highly stable low‐level reagents; which can be further applied make heterocycles more accessible. While several promising exist, multi‐component (MCRs) have drawn much attention both academia industry worldwide, since they are cost‐efficient environmentally friendly. Combining MCRs produced great strategy field research. This review focuses on recent advances electrochemical heterocyclic compounds via reactions, reported between 2015 March 2023.

Language: Английский

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Synthesis of new magnetic nanocatalyst Fe3O4@CPTMO-phenylalanine-Ni and its catalytic effect in the preparation of substituted pyrazoles

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 13, 2023

In this study, a new, efficient and stable magnetically heterogeneous nanocatalyst of Fe3O4@CPTMO-phenylalanine-Ni via multi steps process starting from simple cost-effective precursors was designed successfully synthesized, physico-chemical, structural, magnetic properties have fully been characterized by several analytical methods involving SEM-EDS, FT-IR, TGA, VSM, XRD, ICP, BET, TEM, EMA. The catalytic performance the can be used as an effective recyclable with facile separation forces for preparation substituted pyrazoles high yields through one-pot, three-component condensation reaction various arylglyoxals, diketones, 1H-pyrazole-5-amines under mild conditions. nanocatalyst's activity after being four consecutive times in cycle without distinct deterioration remained unchanged or found to slight decrease. advantages study are simplicity, low cost, synthesis process, environmentally secure nature.

Language: Английский

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Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 385, P. 122398 - 122398

Published: June 20, 2023

Language: Английский

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Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles

Ultrasonics Sonochemistry, Journal Year: 2023, Volume and Issue: 102, P. 106741 - 106741

Published: Dec. 23, 2023

Ultrasonic irradiation serves as a vigorous and environmentally sustainable approach for augmenting multicomponent reactions (MCRs), offering benefits such thermal enhancement, agitation, activation, among others. Malononitrile emerges versatile reagent in this context, participating myriad of MCRs to produce structurally diverse heterocyclic frameworks. This review encapsulates the critical role malononitrile sonochemical synthesis these structures. The paper further delves into biochemical pharmacological implications heterocycles, elucidating their reaction mechanisms well delineating method's scope limitations. We furnish an overview merits challenges inherent synthetic offer insights potential avenues future research.

Language: Английский

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Carbon-based catalysts: advances in synthesizing N-heterocyclic compounds using graphene family and graphite oxide

Research on Chemical Intermediates, Journal Year: 2024, Volume and Issue: 50(2), P. 485 - 531

Published: Jan. 5, 2024

Language: Английский

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Carbon nanotubes as heterogeneous catalysts for the multicomponent reaction synthesis of heterocycles

Carbon letters, Journal Year: 2024, Volume and Issue: 35(1), P. 75 - 105

Published: Oct. 5, 2024

Language: Английский

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Application of novel Fe3O4/Zn-metal organic framework magnetic nanostructures as an antimicrobial agent and magnetic nanocatalyst in the synthesis of heterocyclic compounds

Frontiers in Chemistry, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 10, 2022

Using the microwave-assisted method, novel Fe3O4/Zn-metal organic framework magnetic nanostructures were synthesized. The crystallinity, thermal stability, adsorption/desorption isotherms, morphology/size distribution, and hysteresis of synthesized characterized by XRD patterns, TGA curve, BET technique, SEM image, VSM respectively. After confirming nanostructures, its antimicrobial properties against Gram-positive bacterial, Gram-negative fungal strains based on minimum inhibitory concentration (MIC), bactericidal (MBC), fungicidal (MFC) values studied. MIC in activity for bacterial strains, between 16-128 μg/ml, strain, 128 μg/ml observed. results showed that high specific surface area caused power nanoparticles to be high, observed effects higher than some known commercial drugs. Another advantage was catalytic three-component reaction isatin, malononitrile, dimedone. New spiro [indoline-pyranopyrimidines] derivatives with efficiency. that, addition recyclability, could less time previously reported methods. investigating range 10-20 min an efficiency over 85%. As a final result, it can concluded microwave synthesis method improves unique especially area, has increased

Language: Английский

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A facile hydrothermal synthesis of high-efficient NiO nanocatalyst for preparation of 3,4-dihydropyrimidin-2(1H)-ones

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: May 20, 2022

The present work introduces a one-step and facile hydrothermal procedure as green process for the first time to synthesize nickel(II) oxide (NiO) nanoparticles. as-prepared nanomaterials were used high efficient, low toxic cost catalyst synthesis of some organic compounds. Ni(NO3)2 natural extract surfactant NiO nanomaterials. A yield (91%) was obtained S2. Rietveld analysis affirmed cubic crystal system nanocatalyst. morphology studies carried out with FESEM method images revealed change from non-homogenous homogenous spherical particles when Barberryas instead orange blossom surfactant. Besides, that particle size distribution in range 20 60 nm. synthesized catalysts Biginelli multicomponent reactions (MCRs) preparation 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) under reaction conditions. High (97%) final product achieved at optimum condensation conditions (Catalyst: mg; temperature: 90 °C time: min) ethyl acetoacetate/methyl acetoacetate (1 mmol), benzaldehyde mmol) urea (1.2 used. kinetic study pseudo-first-order model followed model.

Language: Английский

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Microwave-assisted preparation of polysubstituted imidazoles using Zingiber extract synthesized green Cr2O3 nanoparticles

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 19, 2022

Abstract Cr 2 O 3 nanoparticles were prepared using Zingiber officinal extract which used as an efficient and reusable catalyst in the practical synthesis of polysubstituted imidazoles by means a convenient reaction aromatic aldehydes with ammonium acetate benzil under microwave irradiation H solvent. The structure compounds was studied IR 1 H-NMR spectrum. most important benefits this process are operational simplicity, reasonable times, excellent yield products. results show that optimal conditions for formation imidazole derivatives follow: power 400 W, time 4–9 min, solvent, 15 mmol amount.

Language: Английский

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