Cardiovascular complications of the coronavirus disease (COVID-19) DOI Creative Commons
Alexander A. Blokhin, А. Н. Шишкин,

A. I. Knyazeva

et al.

Juvenis scientia, Journal Year: 2022, Volume and Issue: 8(6), P. 6 - 14

Published: Jan. 1, 2022

A new coronavirus infection (COVID-19), which has spread widely in the human population past few years, is often complicated by a damage to cardiovascular system, central nervous gastrointestinal tract, and respiratory system organs. The review describes features of clinical course treatment SARS-CoV-2 infection, can lead development cardiac complications both early long-term periods. It assumed that there are three main causes for such (the affinity virus endothelial proteins, blood vessels heart as result immune response body toxic effects drugs used treat infection). Among pathogenic mechanisms complications, following be distinguished: manifestations systemic vasculitis, coagulopathy, thrombosis, phenomenon “cytokine storm”, direct cytotoxic myocardium, metabolic disorders, imbalance ionic composition blood, hypoxia its consequences. most common include myocarditis with arrhythmia (sinus tachycardia, bradycardia, atrial fibrillation flutter, QTc prolongation, sudden death), cardiomyopathy (biventricular, isolated dysfunction right or left ventricle), cardiogenic shock, thromboembolism (including strokes), vasculitis. Following recovery from COVID-19, many patients retain (or develop) symptoms caused damage: pain region heart, palpitations, appearance aggravation chronic failure, decompensation hypertension, acute coronary syndrome. proposed directions minimizing risk developing COVID-19 ECG monitoring (assessment QT interval, rhythm, conduction repolarization), echocardiography at risk, 24-hour recording who report palpitations. In addition, it recommended adjust dosages cardiotoxic cautious when prescribing anticoagulant therapy.

Language: Английский

Role of endothelial dysfunction and intestinal microbiota in the development metabolic syndrome DOI Creative Commons
А. Н. Шишкин

Новые Санкт-Петербургские врачебные ведомости., Journal Year: 2025, Volume and Issue: 3, P. 81 - 89

Published: Jan. 28, 2025

In the article data is about pathogenesis of endothelial dysfunction in metabolic syndrome. The clinical picture and pathogenic particularities are described. According to recent studies role gut microbiota development syndrome not doubt. Specific bacteria species can be considered as predictors presence.

Language: Английский

Citations

0
Oxygen-Dependent Aspects of the Action of Asprosyn DOI
В. В. Зинчук,

J. S. O. Al-Jebur

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(4), P. 547 - 560

Published: Sept. 28, 2024

A new hormone from the group of adipokines, called asprosin, was discovered in adipose tissue, which is a regulator body’s reactions to short-term fasting, initiates release glucose liver and increases appetite, total amount energy reserves tissue. This hormone, determining bioenergetic status body, affects oxygen content tissues, and, accordingly, transport function blood case excess body weight insulin resistance. In persons with an increased asprosin overweight obesity first degree, as well resistance, change position oxyhemoglobin dissociation curve observed, accompanied by increase concentration gas transmitter nitrogen monoxide decrease level hydrogen sulfide. factor involved regulation system formation mechanisms. The contribution supply adaptive individuals metabolic disorders, reflects aspect mechanism its action.

Language: Английский

Citations

0
Oxygen-Dependent Aspects of Asprosin Action DOI
В. В. Зинчук,

J. S. O. Al-Jebur

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(2), P. 818 - 828

Published: March 1, 2024

Language: Английский

Citations

0
Some Features of Correction of Adipose Tissue Dysfunction DOI Creative Commons

P.Yu. Filiniuk,

А. Н. Шишкин, Ivan Pchelin

et al.

Juvenis scientia, Journal Year: 2023, Volume and Issue: 9(6), P. 6 - 17

Published: Dec. 30, 2023

The rapid spread of obesity and associated cardiovascular disease is serious concern in the scientific medical field. Despite diverse approaches to solving these problems, there still no visible success fight against at population level, pathology remains one main causes death disability world. This leads attempts aimed finding new therapeutic options. Targeted pharmacological therapy for adipose tissue dysfunction represents potential solutions. In present article, we review effects adipocytokines such as adiponectin leptin, most well-studied markers disruption normal functioning tissue, well some modern correction their on system. analysis data shows that hypoadiponectinemia hyperleptinemia combination with leptin resistance are poor prognosis, pathologically altered levels above-mentioned achieve optimal ratio may represent a relevant goal.

Language: Английский

Citations

1
Cardiovascular complications of the coronavirus disease (COVID-19) DOI Creative Commons
Alexander A. Blokhin, А. Н. Шишкин,

A. I. Knyazeva

et al.

Juvenis scientia, Journal Year: 2022, Volume and Issue: 8(6), P. 6 - 14

Published: Jan. 1, 2022

A new coronavirus infection (COVID-19), which has spread widely in the human population past few years, is often complicated by a damage to cardiovascular system, central nervous gastrointestinal tract, and respiratory system organs. The review describes features of clinical course treatment SARS-CoV-2 infection, can lead development cardiac complications both early long-term periods. It assumed that there are three main causes for such (the affinity virus endothelial proteins, blood vessels heart as result immune response body toxic effects drugs used treat infection). Among pathogenic mechanisms complications, following be distinguished: manifestations systemic vasculitis, coagulopathy, thrombosis, phenomenon “cytokine storm”, direct cytotoxic myocardium, metabolic disorders, imbalance ionic composition blood, hypoxia its consequences. most common include myocarditis with arrhythmia (sinus tachycardia, bradycardia, atrial fibrillation flutter, QTc prolongation, sudden death), cardiomyopathy (biventricular, isolated dysfunction right or left ventricle), cardiogenic shock, thromboembolism (including strokes), vasculitis. Following recovery from COVID-19, many patients retain (or develop) symptoms caused damage: pain region heart, palpitations, appearance aggravation chronic failure, decompensation hypertension, acute coronary syndrome. proposed directions minimizing risk developing COVID-19 ECG monitoring (assessment QT interval, rhythm, conduction repolarization), echocardiography at risk, 24-hour recording who report palpitations. In addition, it recommended adjust dosages cardiotoxic cautious when prescribing anticoagulant therapy.

Language: Английский

Citations

2