Hematologic indices as an available tool in the diagnosis of adverse course of COVID-19 DOI Creative Commons
В. И. Подзолков, Elena V. Volchkova, Anna E. Pokrovskaya

et al.

Terapevticheskii arkhiv, Journal Year: 2024, Volume and Issue: 96(11), P. 1028 - 1034

Published: Dec. 16, 2024

Aim. To study the prognostic significance of hematologic indices: neutrophils/lymphocytes (N/L), platelets/lymphocytes (P/L) and lymphocytes/C-reactive protein (L/CRP) in relation to complicated course new coronavirus infection (COVID-19), as well their correlation with COVID-19 severity indices endothelial dysfunction marker sVCAM-1. Materials methods. 103 patients (COVID-19) were included study. Based on data multispiral computed tomography (CT) chest organs, all divided into 3 groups: CT group 1 – 30 patients, 2 62 11 patients. Results. The values N/L P/L significantly higher compared 2. L/CRP index, contrary, decreased increasing CT-degree lung lesion. concentration sVCAM-1 was CT-3 groups CT-1 272.7 [267.4; 342.6] ng/mL 212.5 [90.3; 335.6] vs 120.0 [75.3; 189.2] ng/mL. Significant correlations studied clinical, laboratory instrumental characteristics found. associated blood (r=0.28 -0.33 respectively; p0.05). N/L2.53 L/CRP≤0.043 are predictors development cytokine storm examined Conclusion. Hematologic N/L, correlated severity, presence (P/L L/CRP) allow predicting (N/L L/CRP).

Language: Английский

Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines DOI Creative Commons
О. М. Драпкина, А. V. Kontsevaya, А. М. Калинина

et al.

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2024, Volume and Issue: 23(3), P. 3696 - 3696

Published: April 1, 2024

Создание руководства поддержано Советом по терапевтическим наукам отделения клинической медицины Российской академии наук.

Language: Русский

Citations

16
Asthma as a manifestation of post-COVID syndrome DOI Creative Commons
И. В. Демко,

K. I. Chinyakova,

А. Yu. Kraposhina

et al.

Bulletin physiology and pathology of respiration, Journal Year: 2025, Volume and Issue: 95, P. 126 - 134

Published: March 20, 2025

Introduction. One of the most common complications novel coronavirus infection (COVID-19) involves respiratory system disorders, particularly bronchial obstruction. Aim. To highlight importance vigilance regarding onset diseases, including asthma, in post-COVID period. Results. This article describes a clinical case newly diagnosed severe asthma 35-year-old patient following COVID-19. A notable feature patient’s condition was prolonged eosinophilia. Sensitization to inhalant allergens ruled out by negative Phadiatop ImmunoCAP screening test. Despite receiving fixed triple combination an inhaled corticosteroid, long-acting β 2 agonist, and anticholinergic agent, disease remained uncontrolled with persistent airway genetically engineered biological therapy subsequently prescribed, resulting marked improvement. Conclusion. illustrates manifestation syndrome—new-onset asthma. Timely diagnosis enables prompt selection appropriate therapy, improving quality life facilitating return normal daily activities.

Language: Английский

Citations

0
Analytical review of respiratory infections role in patients with chronic obstructive pulmonary disease and asthma. Part 1. Characteristics of respiratory infections and their long-term consequences DOI
М. И. Смирнова, D. N. Antipushina, А. V. Kontsevaya

et al.

Russian Journal of Preventive Medicine, Journal Year: 2024, Volume and Issue: 27(1), P. 90 - 90

Published: Jan. 1, 2024

Language: Английский

Citations

1
Relationship between dyspnea and respiratory function indicators after coronavirus pneumonia DOI Creative Commons
А. В. Мелехов, В. И. Светлаков,

S. A. Bedritsky

et al.

Bulletin physiology and pathology of respiration, Journal Year: 2024, Volume and Issue: 92, P. 29 - 39

Published: June 18, 2024

Aim. To study the relationship between probability and severity of dyspnea following COVID-19 pneumonia with characteristics lung ventilatory function (LVF), diffusion capacity (DCL), respiratory muscle strength (RMS) impairments. Materials methods. A total 108 patients (58% women, age 62 [52-66] years) who had recovered from were examined. Spirometry, bodyplethysmography, DCL, RMS assessments conducted 75 (46-155) days after onset disease. The was evaluated using MRC (Medical Research Council Scale) 10-point Borg scale. Instrumental laboratory data acute phase retrospectively obtained medical records. Results. risk any at time examination statistically significantly higher in reduced (z-score < -1.645) VC, FVC, FEV 1 , DLCO, VA, DLCO/VA. No correlation found indicators (maximum C-reactive protein, lactate dehydrogenase levels, tissue damage assessed by computed tomography, positive PCR test), sex, or body mass index. None a Gensler index <70%; however, 10.3% patients. Restrictive LVF impairments observed 8.3% patients, mixed 11.2%. Dyspnea impairments, especially type, compared to normal biomechanics. functional parameters persisted even when sample limited (n=75) without comorbidities (n=49). In no did not report dyspnea, ITGV, DLCO/VA values (in % predicted) higher, Raw Rocc lower than those dyspnea. Conclusion. There is restrictive, obstructive VFL DCL post-COVID-19 period. Additionally, identified patterns suggest that subclinical bronchial obstruction may be possible mechanisms biomechanics pattern.

Language: Английский

Citations

0
Post-COVID respiratory disorders DOI Open Access
И. В. Лещенко, Т. В. Глушкова, N. A. Esaulova

et al.

Published: July 23, 2024

По крайней мере 1 симптом респираторных нарушений регистрируется через мес.после перенесенной инфекции COronaVIrus Disease-2019 (COVID-19) у 54% больных, 2-5 мес.-у 55%, ≥ 6 больных [1].Респираторные проявления представлены преимущественно жалобами на одышку (14-35% случаев), кашель (5-40%), боль в грудной клетке (5-29%) и отхождение мокроты (2-4%) [2].Через 4-8 нед.после завершения стационарного лечения COVID-19 одышка регистрировалась 65,6% ранее помещенных отделении интенсивной терапии (ОРИТ), 42,6% находившихся общей палате [3].Учитывая высокий процент частоты регистрируемых жалоб

Language: Русский

Citations

0
Lung function in patients with asthma in the post-COVID period DOI
Elena E. Mineeva, М. V. Аntonyuk,

А. V. Yurenko

et al.

Bulletin physiology and pathology of respiration, Journal Year: 2024, Volume and Issue: 1(93), P. 72 - 82

Published: Sept. 12, 2024

Aim . To assess the lung function in patients with bronchial asthma (BA) after new-onset coronavirus infection. Materials and methods Fifty-five who underwent COVID-19 participated study under conditions of voluntary informed consent. The main group consisted 30 mild BA, comparison – 25 without chronic respiratory diseases (CRD). According to chest computed tomography (CT) findings, degree parenchyma involvement was classified as follows: (CT 0 stage) 14 patients; moderate 1-2 stages) 27 severe 3-4 patients. Lung tests were conducted once, adhering both Russian international standards. Results In obstructive pulmonary impairment predominant at CT stages (79%), stage (67%), (43%). diffusion capacity (LDC) impaired predominantly BA those CRD, occurring 57% cases. Analysis showed that LDC reduction detected 17% cases 24% non-CRD There no statistically significant changes ventilation among compared CRD. Conclusion All symptoms should undergo comprehensive assessment identify obstruction, capacity, ensure timely intervention.

Language: Английский

Citations

0
Current aspects of differential diagnosis and treatment of cough DOI Creative Commons
Д. И. Трухан, В. В. Голошубина, V. I. Gusina

et al.

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Cough is a common and important respiratory symptom that can cause significant complications for patients be diagnostic challenge physicians. An organized approach to the evaluation of cough begins with classifying it as acute, subacute, or chronic based on duration time onset. Acute (up 3 weeks) most often one main symptoms acute viral infections bronchitis. Subacute cough, lasting from 8 weeks, usually postinfectious postviral in origin. Common causes more than weeks normal chest X-ray are variant bronchial asthma, obstructive pulmonary disease, upper airway syndrome / postnasal drip syndrome, non-asthmatic eosinophilic bronchitis, gastroesophageal reflux, medications (primarily angiotensin-converting enzyme inhibitors). The spectrum possible diverse, however, pathology comes forefront differential search. Successful treatment an task clinical practice. Given multicomponent nature presence catarrhal-respiratory broncho-obstructive syndromes picture along bronchitis combination drugs become drug choice. In conclusion, possibilities combined (bromhexine + guaifenesin salbutamol) expectorant against its effectiveness safety considered.

Language: Английский

Citations

0
Hematologic indices as an available tool in the diagnosis of adverse course of COVID-19 DOI Creative Commons
В. И. Подзолков, Elena V. Volchkova, Anna E. Pokrovskaya

et al.

Terapevticheskii arkhiv, Journal Year: 2024, Volume and Issue: 96(11), P. 1028 - 1034

Published: Dec. 16, 2024

Aim. To study the prognostic significance of hematologic indices: neutrophils/lymphocytes (N/L), platelets/lymphocytes (P/L) and lymphocytes/C-reactive protein (L/CRP) in relation to complicated course new coronavirus infection (COVID-19), as well their correlation with COVID-19 severity indices endothelial dysfunction marker sVCAM-1. Materials methods. 103 patients (COVID-19) were included study. Based on data multispiral computed tomography (CT) chest organs, all divided into 3 groups: CT group 1 – 30 patients, 2 62 11 patients. Results. The values N/L P/L significantly higher compared 2. L/CRP index, contrary, decreased increasing CT-degree lung lesion. concentration sVCAM-1 was CT-3 groups CT-1 272.7 [267.4; 342.6] ng/mL 212.5 [90.3; 335.6] vs 120.0 [75.3; 189.2] ng/mL. Significant correlations studied clinical, laboratory instrumental characteristics found. associated blood (r=0.28 -0.33 respectively; p0.05). N/L2.53 L/CRP≤0.043 are predictors development cytokine storm examined Conclusion. Hematologic N/L, correlated severity, presence (P/L L/CRP) allow predicting (N/L L/CRP).

Language: Английский

Citations

0