EFSA Journal,
Journal Year:
2024,
Volume and Issue:
22(11)
Published: Nov. 1, 2024
Abstract
Genetically
modified
Komagataella
phaffii
strain
MXY0541
was
developed
to
produce
soy
leghemoglobin
by
introducing
the
LGB2
coding
sequence
encoding
from
soybean
(Glycine
max).
The
molecular
characterisation
data
and
bioinformatic
analyses
do
not
raise
any
safety
concerns.
of
as
a
food
additive
has
already
been
assessed
EFSA
FAF
Panel
(EFSA‐Q‐2022‐00031).
GMO
does
identify
concerns
regarding
toxicity
allergenicity
protein
expressed
in
K.
phaffii,
finds
no
evidence
that
genetic
modification
would
change
its
overall
allergenicity.
concludes
LegH
Prep
derived
genetically
is
safe
for
human
consumption
with
regard
effects
modification.
No
environmental
impact
use
this
product
expected
recombinant
DNA
sequences
possibly
remaining
product.
respect
potential
on
health
environment
at
proposed
level
far
concerned.
conclusion
lead
issues.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 15, 2024
Manganese
(Mn)
is
widely
recognized
owing
to
its
low
cost,
non-toxic
nature,
and
versatile
oxidation
states,
leading
the
emergence
of
various
Mn-based
nanomaterials
with
applications
across
diverse
fields,
particularly
in
tumor
diagnosis
therapy.
Systematic
reviews
specifically
addressing
therapy
aspects
Mn-derived
biomaterials
are
lacking.
This
review
comprehensively
explores
physicochemical
characteristics
synthesis
methods
biomaterials,
emphasizing
their
role
diagnostics,
including
magnetic
resonance
imaging,
photoacoustic
photothermal
ultrasound
multimodal
biodetection.
Moreover,
advantages
materials
treatment
discussed,
drug
delivery,
microenvironment
regulation,
synergistic
photothermal,
photodynamic,
chemodynamic
therapies,
immunotherapy,
imaging-guided
The
concludes
by
providing
insights
into
current
landscape
future
directions
for
Mn-driven
advancements
field,
serving
as
a
comprehensive
resource
researchers
clinicians.
EFSA Journal,
Journal Year:
2024,
Volume and Issue:
22(7)
Published: July 1, 2024
Abstract
Following
a
request
from
the
European
Commission,
EFSA
Panel
on
Nutrition,
Novel
Foods
and
Food
Allergens
(NDA)
was
asked
to
deliver
an
opinion
Acheta
(A.)
domesticus
powder
as
novel
food
(NF)
pursuant
Regulation
(EU)
2015/2283.
The
main
components
of
NF
are
protein,
fat
dietary
fibre
(chitin).
notes
that
concentration
contaminants
in
depends
occurrence
levels
these
substances
insect
feed.
further
there
no
safety
concerns
regarding
stability
if
complies
with
proposed
specification
limits
during
its
entire
shelf‐life.
has
high
protein
content,
although
true
content
is
overestimated
when
using
nitrogen‐to‐protein
conversion
factor
6.25
due
presence
non‐protein
nitrogen
chitin.
applicant
use
ingredient
number
products.
target
population
by
general
population.
Considering
composition
conditions
use,
consumption
not
nutritionally
disadvantageous.
panel
arise
toxicological
information
A.
domesticus.
considers
might
trigger
primary
sensitisation
proteins
may
cause
allergic
reactions
subjects
crustaceans,
mites
molluscs.
Additionally,
allergens
feed
end
up
NF.
concludes
safe
under
uses
levels.
EFSA Journal,
Journal Year:
2023,
Volume and Issue:
21(12)
Published: Dec. 1, 2023
Following
a
request
from
the
European
Commission
(EC),
EFSA
Panel
on
Nutrition,
Novel
Foods
and
Food
Allergens
(NDA)
was
asked
to
deliver
scientific
opinion
tolerable
upper
intake
level
(UL)
for
manganese.
Systematic
reviews
of
literature
human
animal
data
were
conducted
assess
evidence
regarding
excess
manganese
(including
authorised
salts)
priority
adverse
health
effect,
i.e.
manganese-induced
neurotoxicity.
Available
studies
support
neurotoxicity
as
critical
however,
are
not
sufficient
suitable
characterise
dose–response
relationship
identify
reference
point
In
absence
adequate
establish
an
UL,
estimated
background
dietary
intakes
(i.e.
natural
sources
only)
observed
among
high
consumers
(95th
percentile)
used
provide
indication
highest
where
there
is
reasonable
confidence
effects.
A
safe
8
mg/day
established
adults
≥
18
years
pregnant
lactating
women)
ranged
between
2
7
other
population
groups.
The
application
more
limited
than
UL
because
at
which
risk
effects
starts
increase
defined.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(7), P. 467 - 467
Published: June 27, 2024
The
study
aimed
to
determine
the
content
of
17
elements
(Al,
As,
Ba,
Cd,
Co,
Cr,
Cu,
Fe,
Li,
Mn,
Mo,
Ni,
Pb,
Sb,
Se,
Sr,
and
Zn)
in
samples
sheep
milk,
cheese,
whey
(36
total)
collected
from
a
farm
an
environmentally
burdened
area
due
long-term
mining
industrial
activity
Slovakia
as
well
possible
risk
consumption
via
health
assessment
calculations.
Consumption
120
g
500
20
100
cheese
were
used
calculations
for
children
adults,
respectively.
According
results,
concentrations
four
are
controversial.
Lead
all
types
exceeded
maximum
permissible
lead
limit
milk
set
by
European
Union
legislation.
Se
As
is
problematic
children’s
consumption,
target
hazard
quotient
Al
higher
than
one
(considered
potentially
not
safe)
scenarios.
system
approach,
could
adversely
influence
nervous
kidneys
adults’
developmental
reproductive
systems.
Considering
worst-case
scenario,
consuming
monitored
areas
represent
be
harmful
human
health,
mainly
children.
However,
further
monitoring
levels
more
robust
data
on
needed.
The Science of The Total Environment,
Journal Year:
2025,
Volume and Issue:
966, P. 178700 - 178700
Published: Feb. 1, 2025
In
the
last
two
decades,
research
has
elucidated
that
selenium,
a
trace
element,
both
nutritional
and
toxicological
effects
on
human
health,
depending
its
dose
chemical
form.
Recent
animal,
laboratory,
studies
have
shown
harmful
of
certain
selenium
species
at
specific
exposure
levels,
prompting
need
to
reassess
overall
this
including
occurring
through
drinking
water,
primary
source
inorganic
selenium.
Drinking
water
standards
worldwide
are
scarce
existing
inconsistent,
likely
because
they
been
informed
by
an
incomplete
outdated
assessment
scientific
evidence.
Incorporating
all
available
laboratory
evidence
into
precautionary
regulatory
framework
indicates
limit
around
5
μg/L
is
needed
protect
i.e.
with
uncertainty
factor
2
versus
lowest
adverse
effect
level
observed
in
studies,
higher
values
may
pose
unacceptable
risks
humans.
Despite
rarity
such
high
levels
underground
potable
waters,
coal
mining
other
sources
environmental
pollution
as
well
geological
factors
raise
content
above
safe
threshold,
triggering
consumers,
face
challenging
technological
issues
for
removal,
currently
under
active
investigation.
Journal of Environmental Exposure Assessment,
Journal Year:
2025,
Volume and Issue:
4(2)
Published: April 8, 2025
Infants
and
toddlers
are
exposed
to
environmental
contaminants
elements
also
via
food.
Due
its
high
proportion
in
young
children’s
diet,
infant
formula
can
contribute
significantly
exposure.
The
present
study
describes
the
exposure
such
as
inorganic
arsenic
(iAs),
cadmium
(Cd),
chromium
(Cr),
manganese
(Mn),
mercury
(Hg),
nickel
(Ni),
lead
(Pb),
selenium
(Se),
zinc
(Zn)
consumption
classifies
total
dietary
children
aged
0.5-3
years
Germany.
assessment
of
long-term
was
based
on
data
from
first
diet
(TDS)
Germany,
BfR
MEAL
Study,
nutrition
survey
KiESEL.
Results
were
compared
existing
health-based
guidance
values
(HBGV)
or
margin
(MoE)
approach
used.
Cr,
Ni,
Se
well
below
corresponding
HBGV.
No
HBGV
established
for
Hg,
so
results
transformed
into
Hg.
Mn
Zn
exposures
close
95th
percentile
MoE
Pb
one.
iAs
one
all
children,
Cd
levels
exceeded
about
30%
infants
toddlers.
These
support
risk
managers
continuing
prioritizing
reduction
strategies
reduce
Exposure
contaminants,
particularly
Mn,
Zn,
Pb,
iAs,
Cd,
through
should
be
further
monitored.
