Journal of Food Protection, Journal Year: 2025, Volume and Issue: unknown, P. 100520 - 100520
Published: May 1, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6662 - 6662
Published: June 17, 2024
Humans are continuously exposed to various heavy metals including copper, iron, cadmium, and arsenic, which were specifically selected for the current analysis because they among most frequently encountered environmental mankind industrial pollutants potentially causing human health hazards liver injury. So far, these issues poorly assessed remained a matter of debate, also due inconsistent results. The aim actual report is thoroughly analyze positive as well negative effects four on health. Copper iron correctly viewed pollutant elements essential maintaining part important enzymes metabolic pathways. Healthy individuals prepared through genetically based mechanisms maintain cellular copper homeostasis, thereby circumventing or reducing hazardous organ injury excessive amounts entering body. In few humans with gene aberration, however, may develop excessively accumulated can lead Wilson disease substantial deposition hemochromatosis. At molecular level, toxicities some traced back Haber Weiss Fenton reactions involving reactive oxygen species formed in course oxidative stress. On other hand, homeostasis cadmium arsenic cannot be provided, their life-long organs. Consequently, represent leading higher disability-adjusted life years increased mortality rates cancer non-cancer diseases. For unknown reasons, rarely observed. sum, good except those hemochromatosis at risk radical formation, while lack any beneficial but rather focus disability potential cancer. Primary efforts should emission metals.
Language: Английский
Citations
19
Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)
Published: Feb. 29, 2024
Abstract Health concerns about the toxicity of arsenic compounds have therefore encouraged development new analytical tools for quick monitoring in real samples with improved sensitivity, selectivity, and reliability. An overview advanced optical colorimetric sensor techniques real-time inorganic species environment is given this review paper. Herein, several arsenite (As +3 ) arsenate +5 based on doping chromogenic dyes/reagents, biomolecule-modified nanomaterials, arsenic-binding ligand tethered nanomaterials are introduced discussed. This also highlights benefits limitations species. Finally, prospects future developments an proposed. For study sector, particularly field application, authors recommend paper will be helpful readers to understand design principles their corresponding sensing mechanisms various sensors.
Language: Английский
Citations
10
Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Language: Английский
Citations
1
Food Additives & Contaminants Part A, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17
Published: Jan. 8, 2025
Arsenic (As) occurs naturally in different forms and oxidation states. Amongst them, inorganic arsenic (iAs) is classified as both genotoxic carcinogenic whilst other organic species are considered less toxic. As rice mainly present the form of iAs which therefore poses a health risk to populations that consume staple food. In 2011, Joint Food Agriculture Organisation/World Health Organisation Expert Committee on Additives determined benchmark dose lower confidence limit for 0.5% increased incidence lung cancer humans (BMDL
Language: Английский
Citations
1
EFSA Journal, Journal Year: 2024, Volume and Issue: 22(7)
Published: July 1, 2024
Abstract The European Commission asked EFSA for a risk assessment on small organoarsenic species in food. For monomethylarsonic acid MMA(V), decreased body weight resulting from diarrhoea rats was identified as the critical endpoint and BMDL10 of 18.2 mg MMA(V)/kg (bw) per day (equivalent to 9.7 As/kg bw day) calculated reference point (RP). dimethylarsinic DMA(V), increased incidence urinary bladder tumours endpoint. A 1.1 DMA(V)/kg 0.6 an RP. other species, toxicological data are insufficient identify effects RPs, they could not be included assessment. both MMA(V) database is incomplete margin exposure (MOE) approach applied characterisation. highest chronic dietary DMA(V) estimated ‘Toddlers’, with rice fish meat main contributors across population groups. exposures were high consumers processed/preserved ‘Infants’ ‘Elderly’ age class, respectively. MOE ≥ 500 raise health concern. all MOEs well above average thus do 10,000 low concern it genotoxic carcinogenic, although mechanisms genotoxicity its role carcinogenicity fully elucidated. below many cases surveys groups, particular some 95th percentile exposures. Panel considers that this would
Language: Английский
Citations
7
Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(12), P. 3033 - 3044
Published: March 23, 2024
Abstract Seaweed is becoming increasingly popular in the Western diet as consumers opt for more sustainable food sources. However, seaweed known to accumulate high levels of arsenic—which may be form carcinogenic inorganic arsenic (iAs). Here we propose a fast method routine measurement iAs using HPLC-ICP-MS without coelution arsenosugars that complicate quantification. The developed was optimised design experiments (DOE) and tested on range reference materials including TORT-3 (0.36 ± 0.03 mg kg −1 ), DORM-5 (0.02 0.003 DOLT-5 (0.07 0.007 ). use nitric acid extraction solution allowed successful removal interferences from by causing degradation an unretained arsenosugar species, recovery 99 9% obtained Hijiki 7405-b when compared with certified value. found suitable high-throughput analysis feed matrices Asparagopsis taxiformis seaweed, grass silage, insect proteins, offers cost-effective, fast, robust option requires minimal sample preparation. limited regards quantification dimethylarsenate (DMA) acidic lead overestimation this analyte lipid species are typically abundant than other marine (i.e. arsenophospholipids). concentrations DMA quantified provide better estimation regard exposure after ingestion subsequent digestion seaweed.
Language: Английский
Citations
5
EFSA Journal, Journal Year: 2024, Volume and Issue: 22(7)
Published: July 1, 2024
Abstract EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The provides an introduction illustrates the typical biases, which may be present different study designs. It then describes key concepts relevant appraisal. This includes brief explanations measures of association, exposure assessment, statistical inference, systematic error effect modification. concept external validity principles studies. customisation appraisal process is explained including tailoring tools assessing risk bias (RoB). Several examples experimental observational using RoB tool are annexed illustrate application approach. latter part this focuses steps integration, first within across streams evidence. With respect characterisation, considers how human can used dose–response modelling with several options being presented. Finally, addresses uncertainty factors characterisation when
Language: Английский
Citations
4
EFSA Journal, Journal Year: 2024, Volume and Issue: 22(9)
Published: Sept. 1, 2024
Abstract The EFSA Panel on Food Additives and Flavourings (FAF) provides a scientific opinion the safety of curdlan as new food additive used firming gelling agent, stabiliser, thickener. Curdlan is high molecular weight polysaccharide consisting β‐1,3‐linked glucose units, produced by fermentation from Rhizobium radiobacter biovar 1 strain NTK‐u. toxicological dataset consisted sub‐chronic, chronic carcinogenicity, reproductive developmental toxicity studies well genotoxicity. In vivo data showed that not absorbed such but extensively metabolised gut microbiota into CO2 other innocuous compounds. was genotoxic well‐tolerated with no overt organ‐specific toxicity. Effects observed at very doses curdlan, decreased growth increased cecum weight, are common for indigestible bulking compounds therefore considered physiological responses. combined three‐generation study, pup during lactation 7500 mg curdlan/kg body (bw) per day, highest dose tested. effects treatment‐related adverse, although likely secondary to nutritional imbalance identified conservative adverse effect level (NOAEL) 2500 mg/kg bw day. Despite limitations noted in dataset, able conclude applying margin exposure (MOE) approach. Given its break‐down products neither systemic nor local, adjustment factor deemed necessary. Thus, an MOE least sufficient. estimate 1441 day toddlers 95th percentile proposed maximum use assessment scenario. concluded there concern uses levels.
Language: Английский
Citations
4
Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141749 - 141749
Published: Oct. 22, 2024
Language: Английский
Citations
4
EFSA Journal, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 1, 2025
Abstract Citric acid esters of mono‐ and diglycerides fatty acids (E 472c) was re‐evaluated in 2020 by the Food Additives Flavourings Panel (FAF Panel) along with acetic acid, lactic tartaric diacetyltartaric mixed 472a,b,d,e,f). As a follow‐up to this assessment, FAF requested assess safety citric for its use as food additive infants below 16 weeks age belonging categories (FCs) 13.1.1 (Infant formulae defined Directive 2006/141/EC) 13.1.5.1 (Dietary foods special medical purposes infants). In addition, address recommendation re‐evaluation E 472c update EU specifications Commission Regulation (EU) No 231/2012. For this, call data published allow interested partied provide information risk assessment. The concluded that technical provided business operators support an amendment 472c. Regarding age, there is no concern from at reported levels maximum permitted (FCs 13.1.5.1).
Language: Английский
Citations
0