Procyanidin B2 Mitigates Methotrexate-Induced Hepatic Pyroptosis by Suppressing TLR4/NF-κB and Caspase-3/GSDME Pathways

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115341 - 115341

Published: Feb. 1, 2025

Language: Английский

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Suppression of glomerular damage, inflammation, apoptosis, and oxidative stress of acute kidney injury induced by cyclophosphamide toxicity using resveratrol in rat models

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102548 - 102548

Published: Aug. 30, 2024

Language: Английский

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MicroRNA-155 modulates methotrexate-induced spatial memory impairment by disruption of the blood-brain barrier integrity

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111240 - 111240

Published: Feb. 1, 2025

Methotrexate (MTX) is a commonly used chemotherapy drug, yet its late neurotoxic side effects are gaining attention. The aim of the study was to evaluate role miR-155 in pathogenesis MTX-induced cognitive impairment, mainly focused on interplay blood-brain barrier (BBB) integrity and MTX toxicity. We use young rat model mimicking children leukemia treatment protocol, focusing systemic effect central nervous system by intraperitoneal (IP) injection. function evaluated Morris Water Maze test BBB accessed cortex permeability test. Tight junction proteins expression were also examined. Finally, we tested whether anti-miR155 pretreatment can reversed effect. found increased plasma at 24hr after IP treatment. Besides, resulted impaired learning acquisition, which be Furthermore, brain tight changed MTX. revealed protective current for development impairment. induce significant related disruption integrity. plays vital regulation through maintenance

Language: Английский

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The extracts from Centaurea species abolished the cytotoxic effects of doxorubicin on breast cancer cell line – MCF-7 and bortezomib on prostate cancer cell line- PC3.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115271 - 115271

Published: Jan. 1, 2025

Language: Английский

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The vine tea flavonoids extraction by ultrasound-enzyme-assisted and its consequences for antioxidant efficacy and gut microbiota in rats

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: Feb. 27, 2025

Language: Английский

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Effect of thymoquinone on hippocampal spexin levels in cisplatin-induced rats

Neurological Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: May 8, 2025

Neurotoxicity is a known side effect of the chemotherapeutic drug cisplatin (CIS). Thymoquinone (THQ) natural compound with strong neuroprotective, antioxidant, and anti-inflammatory effects. The objective this study to ascertain impact CIS on histopathological, biochemical, spexin (SPX) immunoreactivity in hippocampus, determine whether THQ has protective role against these effects.Twenty-eight male Sprague - Dawley rats (8-10 weeks old,200 ± 20 g) were used randomly divided into four groups (n = 7): control (no administration), (7 mg/kg first day), CIS+THQ day + 10 mg/kg/day THQ), (10 THQ). On 15th day, sacrificed. Hippocampus tissue samples for histological, immunohistochemical analyses. CISadministration significantly increased interleukin-6 (IL-6), malondialdehyde(MDA), histopathological changes, SPX hippocampus.THQ treatment was found reduce adverse effects of.THQ demonstrated neuroprotective againstCIS-induced damage hippocampus by modulating antioxidant activity, inflammatory response, immunoreactivity. We suggest that SPX, whose mechanism action cognitive, physiological, pathological processes remains unclear, plays an active hippocampus-related functions. Further more comprehensive studies are warranted.

Language: Английский

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Sodium butyrate alleviates T‐2 toxin–induced liver toxicity and renal toxicity in quails by modulating oxidative stress–related Nrf2 signaling pathway, inflammation, and CYP450 enzyme system

Journal of Food Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract T‐2 toxin is a member of class A aspergilloides toxins, one the most prevalent mycotoxins that contaminate feed and food. Direct ingestion animals or contaminated by can cause various animal diseases. Butyrate an organic fatty acid featuring four‐carbon chain, which commonly found in form sodium butyrate (NaB). NaB has several biological functions pharmacological effects. However, role alleviating toxin–induced hepatorenal toxicity not been explored. In this study, 240 juvenile quails were evenly assigned into 4 groups. The experimental setup comprised four groups: control group received standard diet; diet containing 0.9 mg/kg toxin; 0.5 g/kg NaB; treatment both NaB. We evaluated histopathological changes kidney liver on Days 14 28 explored molecular mechanisms involving oxidative stress, inflammation, expression nuclear xenobiotic receptors (NXRs). Our results showed exposure–induced inflammation activating stress pathway modulating NXRs to regulate related CYP450 isoforms, ultimately leading injury kidney, whereas ameliorated injury. These offer novel insights underlying protective effects mitigating quails. Practical Application have well described animals, but studies birds are limited. With development society, market scale farming expanding, value meat eggs increasing; there urgent need clarify harm its mechanism.

Language: Английский

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A comparison of the potential of melatonin and tryptophan to ameliorate CCl ₄ -induced hepatic and renal toxicity in Wistar rats

Drug and Chemical Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Sept. 10, 2024

CCl

Language: Английский

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Protection of lutein against the neurotoxicity of cisplatin in the rat brain

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102609 - 102609

Published: Nov. 14, 2024

Language: Английский

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Taurine and enzymatically modified isoquercitrin synergistically protect against the methotrexate-induced cardiotoxicity in rats: antioxidant and antiapoptotic effects

Drug and Chemical Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Nov. 6, 2024

This study aimed to evaluate the protective potential of taurine (Tau) and enzymatically modified isoquercitrin (EMIQ), both individually in combination, against MTX-induced cardiotoxicity male rats. A total 36 rats were randomly divided into six groups (six animals each): control (vehicle), MTX alone (20 mg/kg, single dose), EMIQ+MTX (EMIQ at 26 p.o. for 16 days, with a dose on 13th day), Tau + (Tau 500 (EMIQ+Tau)+MTX, (EMIQ+Tau)½+MTX. treatment resulted elevated levels cardiac creatine phosphokinase-myocardial band, troponin I, nitric oxide, malondialdehyde, serum IL-6, while decreasing myeloperoxidase, catalase, superoxide dismutase. also reduced expression BMI-1, induced DNA laddering fragmentation, increased cleaved caspase-3 protein tissue. Both EMIQ showed equivalent effectiveness protecting heart damage due their antioxidant, anti-inflammatory, antiapoptotic properties. Notably, combined half-doses offered superior protection compared full doses each agent alone. The full-dose combination similar efficacy half-dose few exceptions. Overall, these results suggest synergistic effect mitigating cardiotoxicity, warranting further investigation underlying mechanisms.

Language: Английский

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