The Coronavirus Pandemic: Diagnosis, Treatment and Consequences DOI Open Access
И. И. Логвиненко, М. В. Кручинина, E. V. Garbuzova

et al.

Published: May 11, 2021

Various clinical scenarios of the course post-COVID syndrome in period convalescence were studied.The frequency and volume studies combined pathology patients who have undergone COVID-19 are considered.The controlled indicators medical state within framework follow-up monitoring minimum visits clarified.Key words: New coronavirus infection, convalescents, long COVID syndrome, Introduction.In world as April 22, 2021, World Health Organization (WHO) registered 143 184 614 confirmed cases COVID-19, 223 states territories [1], 82 199 239 people recovered [2].The number Russia exceeded 4.7 million, more than 4.343,229 million [3].To date, has been recognized a multi-organ disease with wide range manifestations [4, 5], WHO obtained factual data on presence persistent symptoms convalescents (fatigue, chronic cough exercise intolerance, cognitive impairment, arthralgia decreased quality life [6, 7, 8]) / or delayed long-term complications after 12 weeks from onset not associated alternative diagnoses (-post-coronavirus syndrome‖) 9].Observational cohort [8, 10] showed that United States 1250 discharged alive, 60 days, 32.6% reported symptoms, including 18.9% about appearance new progression existing ones [10], China [8], when examining 1733 6 months, 76% noted at least one symptom.That is why, organization systematic particular importance.The collection analysis related to possible risks should help make prognosis choice tactics for their management during convalescence, which emphasizes relevance chosen research topic.Purpose: determine changes occur immediate form an optimal scientifically grounded system measures improve dispensary observation such (including duration observation, examination standards) optimization personalized therapy concomitant diseases, increase adherence reduce risk adverse outcomes.12-16 first filling out questionnaires examinations by specialists (pulmonologist, cardiologist, somnologist, neurologist, endocrinologist, therapist), 86.5% having symptoms.indicating mental weakness, increased exhaustion, irritability, productivity processes, sleep disorders, physical performance, other autonomic-somatic disorders.It was found most common problems leading disturbance restless legs 57.5% patients.The comorbid obstructive apnea syndrome: case impaired carbohydrate metabolism, breathing disorders (mainly moderate severe) 85% observed, arterial hypertension diabetes mellitus -in 25.2% cases.Of entire spectrum pulmonary manifestations, symptom shortness breath, both expiratory mixed, 40% had no history respiratory before disease.Discussion.The similar results A. Carfi et al. (Italy) [6], persistence 87.4% acute (with average days symptom).Fatigue (53.1%), breath (43.4%), joint pain (27.3%) chest (21.7%) common, 55% presenting three [6].Fatigue, psychological post-traumatic stress disorder, anxiety, depression, concentration 30% study participants France [26].Conclusion.Clarification features search evidence COVID, gaining knowledge interdisciplinary collaboration indicate series consultations aimed reaching consensus characteristics this its subtypes agreement definition.

Language: Английский

Dermatological manifestations associated with a novel coronavirus infection in the acute and post-acute period of COVID-19 DOI Open Access
O.B. Nemchaninova Nemchaninova, Елена Павловна Симонова

JOURNAL of SIBERIAN MEDICAL SCIENCES, Journal Year: 2023, Volume and Issue: 7(1), P. 7 - 17

Published: Jan. 1, 2023

Introduction. Dermatological manifestations of a novel coronavirus infection caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) are observed in different periods disease, and can sometimes be only manifestation disease 2019 (COVID-19). Despite fact that at present daily increase new cases Russian Federation is small, issues timely diagnosis, treatment prevention COVID-19 remain relevant, experience gained during pandemic invaluable practical importance. Aim. Evaluation dermatological associated with SARS-CoV-2 period post-acute one. Materials methods. A cohort non-comparative descriptive study 120 people aged 48–72 years (44 men, 76 women), who had no earlier than 12 weeks ago, was carried out. Results. Changes skin its appendages were 72 (60%) patients. In 7 (9.7%) people, symptoms appeared represented urticaria, pernio-like lesions feet, edematous erythema face chest, itching hyperesthesia skin. two cases, rashes preceded onset signs infection. post-COVID occurred 94.4% patients, which diffuse alopecia diagnosed 60.3% xerosis and/or paresthesia 48.5%, onychopathy 23.5%, new-onset dermatoses 14.7%, 38.2% – combination several disorders. Conclusion. Among COVID-19, we identify typical characteristic syndrome. The serve as an indicator infection, contributing to diagnosis. Knowledge will allow us correctly conduct diagnostic search prescribe adequate treatment.

Language: Английский

Citations

1
ПАТОГЕНЕТИЧНА РОЛЬ ЕНДОТОКСИКОЗУ В РОЗВИТКУ ТЯЖКИХ ФОРМ COVID-19: КЛІНІКО-ПАТОМОРФОЛОГІЧНЕ ДОСЛІДЖЕННЯ DOI Creative Commons

К. В. Циганков,

Л.Р. Шостакович-Корецька,

В. М. Павленко

et al.

Інфекційні хвороби, Journal Year: 2022, Volume and Issue: 1, P. 24 - 39

Published: June 11, 2022

Мета роботи – на підставі клініко-морфологічного дослідження особливостей уражень легень і шлунково-кишкового тракту різних стадіях запального процесу обґрунтувати гіпотезу ендотоксикозу як ключового патогенетичного фактора системної ендотеліальної дисфункції вторинного ураження при COVID-19. Матеріали методи. Дослідження базується клініко-патоморфологічному вивченні 52 випадків смерті від COVID-19, з яких для ретельного гістологічного був відібранний аутопсійний матеріал 18 померлих. У частині задіяний імерсійний метод мікроскопії, виконували імуногістохімічне дослідження. Результати. Основним проявом альтеративного розвитку дифузного альвеолярного пошкодження (ДАП) мікротромбоз фоні лейкоцитарних пасток, що формувались нетозом гіперактивованих поліморфноядерних лейкоцитів. Встановили відсутність ознак попереднього міграції лейкоцитів через стінки капілярів у просвіт альвеол. Одночасно гістологічна картина змін в тонкій кишці відповідала гострому десквамативно-ерозивному запальному вірусно-бактерійної етіології ознаками активної транслокації ендотоксину. В інфільтраті слизової оболонки тонкої кишки гіперергічні вогнищеві лімфоїдні інфільтрати, стадії ранньої ексудації (p<0,005), так проліферації ДАП (p<0,001). Продемонстровано достовірно низький показник імунорегуляторного індексу (ІРІ) CD4/CD8 гістологічних зразках інфільтрату порівняно ІРІ Запропоновано модель патогенезу згідно якою може виникати вторинно, за механізмом гепатопульмонального синдрому. Висновки. Є підстави вважати, вхідними воротами збудника тяжкому перебігу поряд дихальною системою, є слизова оболонка дистальних відділів кишки. Виявлені морфологічні прояви тяжкої пошкодженням ендотелію свідчать більше про ендотоксином параалергічної реакції, а не пряме вірусне ураження.

Citations

1
THORACIC RADIOLOGY DOI Creative Commons

Article Editorial

Diagnostic radiology and radiotherapy, Journal Year: 2022, Volume and Issue: 13(1S), P. 66 - 79

Published: April 14, 2022

.

Citations

0
EXPERIENCE OF FOLLOW-UP MONITORING OF COVID-19 CONVALESCENTS (LONG COVID SYNDROME) DOI Open Access
И. И. Логвиненко

Published: May 11, 2021

Abstract: Various clinical scenarios of the course post-COVID syndrome in period convalescence were studied. The frequency and volume studies combined pathology patients who have undergone COVID-19 are considered. controlled indicators medical state within framework follow-up monitoring minimum visits clarified. Key words: New coronavirus infection, convalescents, long COVID syndrome,

Language: Английский

Citations

0
The Coronavirus Pandemic: Diagnosis, Treatment and Consequences DOI Open Access
И. И. Логвиненко, М. В. Кручинина, E. V. Garbuzova

et al.

Published: May 11, 2021

Various clinical scenarios of the course post-COVID syndrome in period convalescence were studied.The frequency and volume studies combined pathology patients who have undergone COVID-19 are considered.The controlled indicators medical state within framework follow-up monitoring minimum visits clarified.Key words: New coronavirus infection, convalescents, long COVID syndrome, Introduction.In world as April 22, 2021, World Health Organization (WHO) registered 143 184 614 confirmed cases COVID-19, 223 states territories [1], 82 199 239 people recovered [2].The number Russia exceeded 4.7 million, more than 4.343,229 million [3].To date, has been recognized a multi-organ disease with wide range manifestations [4, 5], WHO obtained factual data on presence persistent symptoms convalescents (fatigue, chronic cough exercise intolerance, cognitive impairment, arthralgia decreased quality life [6, 7, 8]) / or delayed long-term complications after 12 weeks from onset not associated alternative diagnoses (-post-coronavirus syndrome‖) 9].Observational cohort [8, 10] showed that United States 1250 discharged alive, 60 days, 32.6% reported symptoms, including 18.9% about appearance new progression existing ones [10], China [8], when examining 1733 6 months, 76% noted at least one symptom.That is why, organization systematic particular importance.The collection analysis related to possible risks should help make prognosis choice tactics for their management during convalescence, which emphasizes relevance chosen research topic.Purpose: determine changes occur immediate form an optimal scientifically grounded system measures improve dispensary observation such (including duration observation, examination standards) optimization personalized therapy concomitant diseases, increase adherence reduce risk adverse outcomes.12-16 first filling out questionnaires examinations by specialists (pulmonologist, cardiologist, somnologist, neurologist, endocrinologist, therapist), 86.5% having symptoms.indicating mental weakness, increased exhaustion, irritability, productivity processes, sleep disorders, physical performance, other autonomic-somatic disorders.It was found most common problems leading disturbance restless legs 57.5% patients.The comorbid obstructive apnea syndrome: case impaired carbohydrate metabolism, breathing disorders (mainly moderate severe) 85% observed, arterial hypertension diabetes mellitus -in 25.2% cases.Of entire spectrum pulmonary manifestations, symptom shortness breath, both expiratory mixed, 40% had no history respiratory before disease.Discussion.The similar results A. Carfi et al. (Italy) [6], persistence 87.4% acute (with average days symptom).Fatigue (53.1%), breath (43.4%), joint pain (27.3%) chest (21.7%) common, 55% presenting three [6].Fatigue, psychological post-traumatic stress disorder, anxiety, depression, concentration 30% study participants France [26].Conclusion.Clarification features search evidence COVID, gaining knowledge interdisciplinary collaboration indicate series consultations aimed reaching consensus characteristics this its subtypes agreement definition.

Language: Английский

Citations

0