Psilocybin desynchronizes the human brain

Nature, Journal Year: 2024, Volume and Issue: 632(8023), P. 131 - 138

Published: July 17, 2024

Abstract A single dose of psilocybin, a psychedelic that acutely causes distortions space–time perception and ego dissolution, produces rapid persistent therapeutic effects in human clinical trials 1–4 . In animal models, psilocybin induces neuroplasticity cortex hippocampus 5–8 It remains unclear how brain network changes relate to subjective lasting psychedelics. Here we tracked individual-specific with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were before, during for 3 weeks after high-dose (25 mg) methylphenidate (40 mg), brought back an additional 6–12 months later. Psilocybin massively disrupted connectivity (FC) subcortex, causing more than threefold greater change methylphenidate. These FC driven by desynchronization across spatial scales (areal, global), which dissolved distinctions reducing correlations within anticorrelations between networks. Psilocybin-driven strongest the default mode network, is connected anterior thought create our sense space, time self. Individual differences strongly linked experience. Performing perceptual task reduced psilocybin-driven changes. caused decrease weeks. Persistent reduction hippocampal-default may represent neuroanatomical mechanistic correlate proplasticity

Language: Английский

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Frontostriatal salience network expansion in individuals in depression

Nature, Journal Year: 2024, Volume and Issue: 633(8030), P. 624 - 633

Published: Sept. 4, 2024

Language: Английский

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Situating the salience and parietal memory networks in the context of multiple parallel distributed networks using precision functional mapping

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115207 - 115207

Published: Jan. 1, 2025

Language: Английский

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Engaging dystonia networks with subthalamic stimulation

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(2)

Published: Jan. 8, 2025

Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as primary target, recently, of subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not studied in depth. Indeed, historical targets that used surgical dystonia are directly adjacent to STN. Further, multiple types exist, outcomes variable, suggesting all would profit maximally from same target. Therefore, a thorough investigation neural substrates underlying effects on signs symptoms warranted. Here, we analyze multicenter cohort isolated patients with implantations ( N = 58) relate their sites improvements appendicular cervical well blepharospasm. Stimulation ventral oral posterior thalamus surrounding regions were associated dystonia, while dorsolateral STN was limb This dissociation matched by structural connectivity analysis, where cerebellothalamic, corticospinal, pallidosubthalamic tracts hyperdirect subthalamopallidal pathways alleviation On level functional networks, corresponding somatotopic motor cortex, cingulo-opercular network. These findings shed light pathophysiology may guide DBS programming future.

Language: Английский

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Network Localization of Pediatric Lesion‐Induced Dystonia

Annals of Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Dystonia is a movement disorder defined by involuntary muscle contractions leading to abnormal postures or twisting and repetitive movements. Classically dystonia has been thought of as the basal ganglia, but newer results in idiopathic lesion-induced adults point broader motor network dysfunction spanning cerebellum, premotor cortex, sensorimotor, frontoparietal regions. It unclear whether similar shared between different etiologies pediatric dystonia. Three cohorts patients with were identified. The lesion included hypoxia, kernicterus, stroke versus comparison subjects acquired lesions not associated Multivariate lesion-symptom mapping used evaluate anatomy networks showed that putamen globus pallidus (r = 0.41, p < 0.001). Lesion using normative connectome data from healthy children demonstrated these regional findings occurred within common brain-wide involves anterior medial cortical regions overlap cingulo-opercular action-mode somato-cognitive-action networks. We interpret novel evidence for unified brain network, which implicated coordination movement. Elucidation this gives insight into functional origins provides targets investigate therapeutic intervention. ANN NEUROL 2025.

Language: Английский

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Defining the r factor for post-trauma resilience and its neural predictors

Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(6), P. 680 - 693

Published: April 22, 2024

Language: Английский

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The promise of precision functional mapping for neuroimaging in psychiatry

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 16 - 28

Published: July 31, 2024

Language: Английский

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Modeling the neurocognitive dynamics of language across the lifespan

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: March 29, 2024

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting‐state fMRI neuropsychological data from 628 healthy adults (age 18–88) the CamCAN cohort, we performed state‐of‐the‐art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter‐cognitive synergy semantic domain‐general processes. cerebral show default mode network (DMN) suppression coupled fronto‐parietal (FPN) integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age‐related in LP. Relatedly, reduced DMN midlife could compromise ability manage cost FPN integration. This may prompt older adopt more cost‐efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel synergistic, economical, nonlinear, emergent, model, integrating connectomic dimensions within complex system perspective.

Language: Английский

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Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 25, 2025

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily the novel uses of existing technology as well next-generation technology. Our keynote speaker shared vision using neuro artificial intelligence predict depression brain electrophysiology. Innovative applications are currently being explored stroke, disorders consciousness, and sleep, while established treatments for movement like Parkinson's disease refined with adaptive stimulation. Neuromodulation is solidifying its role treating psychiatric such obsessive-compulsive disorder, particularly patients treatment-resistant symptoms. We estimate that 300,000 leads have been implanted date neurologic neuropsychiatric indications. Magnetoencephalography has provided insights into post-DBS physiological changes. field also critically examining ethical implications implants, considering long-term impacts clinicians, patients, manufacturers.

Language: Английский

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Developmental decorrelation of local cortical activity through adolescence supports high-dimensional encoding and working memory

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 73, P. 101541 - 101541

Published: March 4, 2025

Adolescence is a key period for the maturation of cognitive control during which cortical circuitry refined through processes such as synaptic pruning, but how these refinements modulate local functional dynamics to support cognition remains only partially characterized. Here, we used data from longitudinal, adolescent cohort (N = 134 individuals ages 10-31 years, N 202 total sessions) that completed MRI scans at ultra-high field (7 Tesla). We resting state fMRI compute surface-based regional homogeneity (ReHo)-a measure time-dependent correlations in activity between vertex and its immediate neighbors-as an index connectivity across cortex. found widespread decreases ReHo, suggesting increasing heterogeneity specialization circuits adolescence. Decreases ReHo included spatial component overlapped with sensorimotor cingulo-opercular networks, were associated developmental stabilization working memory performance. show are higher intrinsic coding dimensionality, demonstrating may confer computational benefits by facilitating increased capacity encoding information. These results suggest remodeling adolescence become increasingly specialized, higher-dimensional, more capable supporting adult-like functioning.

Language: Английский

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