Cognitive and Neurobiological Correlates for Switching/Inhibition Moderate the Relations Between Word Reading and Reading Comprehension in Hebrew‐Speaking Children: An fMRI Study DOI Creative Commons
Tzipi Horowitz‐Kraus,

Donia Abo‐elhija,

Alan Apter

et al.

Dyslexia, Journal Year: 2024, Volume and Issue: 31(1)

Published: Dec. 9, 2024

ABSTRACT The expanded Simple View of Reading model suggests language processing and word reading as contributors to comprehension points at the participation executive functions supporting these abilities. Switching inhibition are both (EF) contributing reading, especially in languages with two writing systems—shallow deep, such Hebrew. Here, we aimed determine specific role switching/inhibition cognitively neurobiologically among 49 eight‐ 12‐year‐old Hebrew‐speaking children. Children underwent cognitive behavioural testing well a five‐min resting‐state fMRI scan. Functional connectivity fronto‐parietal network related was determined included moderation model. Results suggest that abilities functional within moderate relations between comprehension. This strengthens contribution facilitating supports need include it part SVR

Language: Английский

Neuromodulation of Fear and Anxiety Circuits DOI

Joshua A. Brown,

Kevin J. Clancy, Wen Li

et al.

Current topics in behavioral neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
A critical role of action-related functional networks in Gilles de la Tourette syndrome DOI Creative Commons
Juan Carlos Baldermann, Jan Niklas Petry‐Schmelzer, Thomas Schüller

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 16, 2024

Abstract Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep (DBS) cohorts cohort of tic-inducing lesions to infer critical for treatment occurrence tics mapping sites functional connectome derived 1,000 healthy participants. We find that greater reduction linked higher connectivity DBS (N = 37) with action-related resting-state networks, i.e., the cingulo-opercular (r 0.62; p < 0.001) somato-cognitive action 0.47; 0.002). Regions network best match profiles thalamic DBS. replicate significance targeting an 10). Finally, demonstrate 22) exhibit similar these networks. Collectively, results suggest role pathophysiology GTS.

Language: Английский

Citations

3
Paradigm shift in psychiatric neuroscience: Multidimensional integrative theory DOI Creative Commons
Zhu-Qing Gong, Bharat B. Biswal, Xi‐Nian Zuo

et al.

Medicine Plus, Journal Year: 2024, Volume and Issue: 1(2), P. 100024 - 100024

Published: March 29, 2024

Language: Английский

Citations

2
Cognitive flexibility in neurodevelopmental disorders: insights from neuroimaging and neuropsychology DOI

Emily M. Koithan,

Damion V. Demeter,

Sana A Ali

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 59, P. 101429 - 101429

Published: July 4, 2024

Language: Английский

Citations

1
Network localization of pediatric lesion-induced dystonia DOI Creative Commons
Rose Gelineau‐Morel, Nomazulu Dlamini, Joel Bruss

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 8, 2024

Abstract Objective Dystonia is a movement disorder defined by involuntary muscle contractions leading to abnormal postures or twisting and repetitive movements. Classically dystonia has been thought of as the basal ganglia, but newer results in idiopathic lesion-induced adults point broader motor network dysfunction spanning cerebellum, premotor cortex, sensorimotor, frontoparietal regions. It unclear whether similar shared between different etiologies pediatric dystonia. Methods Three cohorts patients with were identified. The lesion included hypoxia, kernicterus, stroke versus comparison subjects acquired lesions not associated Multivariate lesion-symptom mapping used evaluate anatomy networks Results showed that putamen (stroke: r = 0.50, p <0.01; 0.64, <0.001) globus pallidus (kernicterus, 0.61, <0.01) Lesion using normative connectome data from healthy children demonstrated these regional findings occurred within common brain-wide involves anterior medial cortical regions overlap cingulo-opercular somato-cognitive-action networks. Interpretation We interpret novel evidence for unified brain network, which involved higher order coordination movement. Elucidation this gives insight into functional origins provides targets investigate therapeutic intervention.

Language: Английский

Citations

1
Engaging dystonia networks with subthalamic stimulation. DOI Creative Commons
Konstantin Butenko, Clemens Neudorfer, Till A. Dembek

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 25, 2024

Deep brain stimulation is a viable and efficacious treatment option for dystonia. While the internal pallidum serves as primary target, more recently, of subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure its complex surroundings have not studied in depth. Indeed, multiple historical targets that used surgical dystonia are directly adjacent to STN. Further, types exist, outcomes variable, suggesting all would profit maximally from exact same target. Therefore, thorough investigation neural substrates underlying effects on symptoms warranted. Here, we analyze multi-center cohort isolated patients with implantations (

Language: Английский

Citations

0
Functional Neuroanatomy of Tics DOI
Deanna J. Greene, Damion V. Demeter, Ashley N. Nielsen

et al.

Psychiatric Clinics of North America, Journal Year: 2024, Volume and Issue: 48(1), P. 31 - 44

Published: Oct. 9, 2024

Language: Английский

Citations

0
Modeling the Neurocognitive Dynamics of Language across the Lifespan DOI Creative Commons
Clément Guichet, Sonja Banjac, Sophie Achard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 4, 2023

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting-state fMRI neuropsychological data from 628 healthy adults (age 18-88) the CamCAN cohort, we performed state-of-the-art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter-cognitive synergy semantic domain-general processes. cerebral show DMN (Default Mode Network) suppression coupled FPN (Fronto-Parietal integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age-related in LP. Relatedly, reduced midlife could compromise ability manage cost integration. This may prompt older adopt more cost-efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel SENECA model (Synergistic, Economical, Nonlinear, Emergent, Cognitive Aging), integrating connectomic dimensions within complex system perspective. Highlights Lexical ( ) relies on interplay processes life. Default Network cooperates Fronto-Parietal maintain performance cost. Midlife marks shift, prompting prioritizes performance.

Language: Английский

Citations

1
Lifespan Oscillatory Dynamics in Lexical Production: A Population-based MEG Resting-State Analysis DOI Creative Commons
Clément Guichet, Sylvain Harquel, Sophie Achard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Lexical production remains relatively preserved across the lifespan, but cognitive control demands increase with age to support efficient semantic access. It suggests a domain-general and language-specific component. Current neurocognitive models suggest Default Mode Network (DMN) may drive interplay between these components, impacting trajectory of performance pivotal shift around midlife. However, corresponding time-varying architecture still needs clarification. Here, we leveraged MEG resting-state data from healthy adults aged 18-88 CamCAN population-based sample. We found that DMN temporal dynamics anterior-ventral posterior-dorsal states until midlife mitigate word-finding challenges. Similarly, sensorimotor integration along this posterior path enhances cross-talk lower-level circuitry as dynamic information flow more anterior, higher-order gets compromised. bottom-up, exploitation-based form in aging brain, highlighting abstraction, control, perceptive-motor systems preserving lexical production.

Language: Английский

Citations

0
Brain mechanisms discriminating enactive mental simulations of running and plogging DOI Creative Commons
Roxane Victoria Philips, Chris Baeken, Joël Billieux

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(12)

Published: Aug. 15, 2024

Abstract Enactive cognition emphasizes co‐constructive roles of humans and their environment in shaping cognitive processes. It is specifically engaged the mental simulation behaviors, enhancing connection between perception action. Here we investigated core network brain regions involved enactive as applied to simulations physical exercise. We used a neuroimaging paradigm which participants ( N = 103) were required project themselves running or plogging (running while picking‐up litter) along an image‐guided naturalistic trail. Using both univariate multivariate imaging analyses, find that broad spectrum activation discriminates versus running. Critically, show self‐reported ratings daily life engagement quality (how well able imagine running) modulate reactivity Finally, undertook functional connectivity analyses centered on insular cortex, key region dynamic interplay neurocognitive This analysis revealed increased positive negative patterns insular‐centered condition (as compared condition), thereby confirming role cortex action involving complex sets mechanisms. Taken together, present findings provide new insights into networks

Language: Английский

Citations

0