Long-term safety study of the highly absorbable curcumin formulation TS-P1 in healthy Japanese adults: a randomized, placebo-controlled, double-blind, parallel-group comparative study

Functional Foods in Health and Disease, Journal Year: 2024, Volume and Issue: 14(7), P. 546 - 563

Published: July 26, 2024

Background: Curcumin, a yellow-colored molecule derived from the rhizome of Curcuma longa, has been identified as bioactive compound responsible for numerous pharmacological activities turmeric. However, its bioavailability is very low, limiting potential. We have developed novel curcumin formulation, TS-P1, which exhibits an 85.2-fold higher than raw curcumin. Objective: The aim this study was to evaluate safety long-term intake highly bioavailable curcumin, in healthy Japanese adults. Methods: conducted randomized, placebo-controlled, double-blind, parallel-group comparison study. Ninety adults were assigned either placebo or TS-P1 group and took 150 mg daily 12 weeks. Physical examinations, blood analysis, urinalysis, medical examinations performed every 4 Results: There no adverse events attributed test foods during period. mean change body weight mass index (BMI) at week baseline showed significantly greater reduction group. As there food calorie between groups period, observed appeared be due effect through improved bioavailability. Conclusions: These results suggest that containing 150mg safe. Keyword: Highly curcumin; TS-P1: Theracurmin Super; Body (BMI); (UMIN ID: UMIN000050377)

Language: Английский

Impact of curcumin supplementation on fatigue: a systematic review and meta-analysis

Fatigue Biomedicine Health & Behavior, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Oct. 11, 2024

Objective Considering the anti-inflammatory effects of curcumin and evidence indicating role chronic inflammation in pathophysiology fatigue, this meta-analysis aimed to determine significant effect reducing fatigue.

Language: Английский