Microbiological Research, Journal Year: 2022, Volume and Issue: 265, P. 127204 - 127204
Published: Sept. 17, 2022
Language: Английский
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown
Published: Jan. 3, 2022
Abstract Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone public health response to COVID-19. The emergence hypermutated, increasingly transmissible variants concern (VOCs) threaten this strategy. Omicron, fifth VOC be described, harbours 30 amino acid mutations in including 15 receptor-binding domain. Here, we demonstrate substantial evasion neutralisation by Omicron vitro using sera from vaccinated individuals. Importantly, these data mirrored reduction real-world vaccine effectiveness that is partially restored booster vaccination. We also does not induce cell syncytia and favours TMPRSS2-independent endosomal entry pathway. Such marked changes antigenicity replicative biology may underlie rapid global spread altered pathogenicity variant.
Language: Английский
Citations
135
Emerging infectious diseases, Journal Year: 2022, Volume and Issue: 28(9), P. 1856 - 1858
Published: Aug. 11, 2022
Our analysis of data collected from multiple epidemics in Hong Kong indicated a shorter serial interval and generation time infections with the SARS-CoV-2 Omicron variant. The age-specific case-fatality risk for BA.2.2 case-patients without complete primary vaccination was comparable to that persons infected ancestral strains earlier waves.
Language: Английский
Citations
121
Vaccines, Journal Year: 2022, Volume and Issue: 10(7), P. 1049 - 1049
Published: June 30, 2022
Background: Asymptomatic infections are potential sources of transmission for coronavirus disease 2019, especially during the epidemic SARS-CoV-2 Omicron variant. We aimed to assess percentage asymptomatic among variant-positive individuals detected by gene sequencing or specific polymerase chain reaction (PCR). Methods: searched PubMed, EMBASE, and Web Science from 26 November 2021 13 April 2022. This meta-analysis was conducted following Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines registered with PROSPERO (CRD42022327894). Three researchers independently extracted data two assessed quality using pre-specified criteria. The pooled 95% confidence interval (CI) estimated random-effects models. Results: Our included eight eligible studies, covering 7640 2190 infections. 32.40% (95% CI: 25.30−39.51%) individuals, which higher in population developing countries (38.93%; 19.75−58.11%), vaccine coverage ≥ 80% (35.93%; 25.36−46.51%), a travel history (40.05%; 7.59−72.51%), community infection (37.97%; 10.07−65.87%), median age < 20 years (43.75%; 38.45−49.05%). Conclusion: In this systematic review meta-analysis, individuals. people who were vaccinated, young (median years), had history, infected outside clinical setting (community infection) percentages Screening is required prevent clustered epidemics sustained caused variants, regions that have successfully controlled SARS-CoV-2.
Language: Английский
Citations
119
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: March 3, 2022
Abstract The omicron variant of SARS-CoV-2 has been spreading rapidly across the globe. virus-surface spike protein plays a critical role in cell entry and immune evasion SARS-CoV-2. Here we determined 3.0 Å cryo-EM structure ectodomain. In contrast to original strain where receptor-binding domain (RBD) takes mixture open (“standing up”) closed (“lying down”) conformations, molecules are predominantly conformation, with one upright RBD ready for receptor binding. conformation is stabilized by enhanced inter-domain inter-subunit packing, which involves new mutations strain. Moreover, undergone extensive regions known neutralizing antibodies target, allowing escape surveillance aimed at viral stable sheds light on mechanisms variant.
Language: Английский
Citations
118
Journal of Biomedical Science, Journal Year: 2022, Volume and Issue: 29(1)
Published: Sept. 12, 2022
Abstract The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting broad range of challenges. To help address some the main problems, scientific community has designed vaccines, diagnostic tools and therapeutics for severe acute respiratory syndrome 2 (SARS-CoV-2) infection. rapid pace technology development, especially with regard to represents stunning historic achievement. Nevertheless, many challenges remain be overcome, such as improving vaccine drug treatment efficacies emergent mutant strains SARS-CoV-2. Outbreaks more infectious variants continue diminish utility available vaccines drugs. Thus, effectiveness drugs against most current is primary consideration in continual analyses clinical data that supports updated regulatory decisions. first two granted Emergency Use Authorizations (EUAs), BNT162b2 mRNA-1273, still show than 60% protection efficacy widespread SARS-CoV-2 variant, Omicron. This variant carries 30 mutations spike protein, which largely abrogated neutralizing effects therapeutic antibodies. Fortunately, antibodies antiviral COVID-19 treatments have shown continued benefits. In this review, we provide framework understanding ongoing development efforts different types therapeutics, including small molecule antibody ripple newly variants, updates repurposing efforts, are summarized. addition, summarize trials supporting distribution drugs, broad-spectrum activity strains.
Language: Английский
Citations
117
The Lancet Regional Health - Western Pacific, Journal Year: 2022, Volume and Issue: 29, P. 100592 - 100592
Published: Sept. 7, 2022
In early March 2022, a major outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant spread rapidly throughout Shanghai, China. Here we aimed to provide description epidemiological characteristics and spatiotemporal transmission dynamics under population-based screening lockdown policies implemented in Shanghai.
Language: Английский
Citations
103
Nature, Journal Year: 2023, Volume and Issue: 615(7950), P. 143 - 150
Published: Jan. 11, 2023
Language: Английский
Citations
102
Indoor Air, Journal Year: 2022, Volume and Issue: 32(8)
Published: Aug. 1, 2022
The question of whether SARS-CoV-2 is mainly transmitted by droplets or aerosols has been highly controversial. We sought to explain this controversy through a historical analysis transmission research in other diseases. For most human history, the dominant paradigm was that many diseases were carried air, often over long distances and phantasmagorical way. This miasmatic challenged mid late 19th century with rise germ theory, as such cholera, puerperal fever, malaria found actually transmit ways. Motivated his views on importance contact/droplet infection, resistance he encountered from remaining influence miasma prominent public health official Charles Chapin 1910 helped initiate successful shift, deeming airborne unlikely. new became dominant. However, lack understanding led systematic errors interpretation evidence pathways. next five decades, considered negligible minor for all major respiratory diseases, until demonstration tuberculosis (which had mistakenly thought be droplets) 1962. remained dominant, only few widely accepted before COVID-19: those clearly people not same room. acceleration interdisciplinary inspired COVID-19 pandemic shown mode disease, likely significant infectious
Language: Английский
Citations
80
Heliyon, Journal Year: 2023, Volume and Issue: 9(3), P. e13952 - e13952
Published: Feb. 23, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious and pathogenic virus that first appeared in late December 2019. This SARS-CoV-2 causes an infection of disease called "coronavirus infectious disease-2019 (COVID-19). The World Health Organization (WHO) declared this outbreak great pandemic on March 11, 2020. As January 31, 2023, recorded more than 67 million cases over 6 deaths. Recently, novel mutated variants SARS-CoV are also creating serious health concern worldwide, the future variant still mysterious. increasing daily, scientists trying to combat using numerous antiviral drugs vaccines against SARS-CoV-2. To our knowledge, comprehensive review summarized dynamic nature transmission, (a interest), utilized at glance. Hopefully, will enable researcher gain knowledge vaccines, which pave way identify efficient forthcoming strains.
Language: Английский
Citations
80
Travel Medicine and Infectious Disease, Journal Year: 2021, Volume and Issue: 45, P. 102234 - 102234
Published: Dec. 8, 2021
Language: Английский
Citations
103