Diabetes Research and Clinical Practice, Journal Year: 2023, Volume and Issue: 207, P. 111060 - 111060
Published: Dec. 16, 2023
Language: Английский
PEDIATRICS, Journal Year: 2024, Volume and Issue: 153(3)
Published: Feb. 9, 2024
BACKGROUND AND OBJECTIVES Maternal vaccination may prevent infant coronavirus disease 2019 (COVID-19). We aimed to quantify protection against infection from maternally derived vaccine-induced antibodies in the first 6 months of an infant’s life. METHODS Infants born mothers vaccinated during pregnancy with 2 or 3 doses a messenger RNA COVID-19 vaccine (nonboosted boosted, respectively) had full-length spike (Spike) immunoglobulin G (IgG), pseudovirus 614D, and live virus D614G, omicron BA.1 BA.5 neutralizing antibody (nAb) titers measured at delivery. Infant severe acute respiratory syndrome (SARS-CoV-2) was determined by verified maternal-report laboratory confirmation through prospective follow-up age between December 2021 July 2022. The risk reduction for dose group titer level estimated separate models. RESULTS boosted (n = 204) significantly higher Spike IgG, pseudovirus, nAb delivery than infants nonboosted 271), were 56% less likely acquire (P .03). Irrespective boost, each 10-fold increase IgG delivery, acquiring reduced 47% (95% confidence interval 8%–70%; P .02). Similarly, Wuhan Spike, associated 30%, 46%, 56%, 60% reduction, respectively. CONCLUSIONS Higher transplacental binding substantially SARS-CoV-2 infants, booster amplified period predominance. Until are age-eligible vaccination, maternal provides passive symptomatic early infancy.
Language: Английский
Citations
10
Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
ABSTRACT Seroprevalence studies play an important role in estimating the number of children infected with SARS-CoV-2. We report SARS-CoV-2 seroprevalence seeking medical care for any reason at a free-standing pediatric hospital Seattle, WA over 2.5-year period and four distinct pandemic waves. randomly selected residual serum samples from young adults as inpatients outpatients Seattle Children’s Hospital between June 2020 December 2022 to test presence anti-nucleocapsid (N) antibodies. Samples were categorized into waves based on Washington State epidemiology: Wave 1 (June 2020–October 2020), 2 (November 2020–June 2021), 3 (July 2021–November 4 (December 2021–December 2022). Patient characteristics COVID-19 vaccine status obtained, zip codes used ascertain Social Vulnerability Index (SVI). Multivariable Poisson regression models robust variance estimates examine relationship patient anti-N-positivity each wave. Among 8,040 7,102 patients included analyses, rose 2.4% (95% CI, 2.0%–3.1%) 25.5% CI 23.3%–27.8%) (following Omicron surge). High SVI, Hispanic ethnicity, or use government insurance was associated increased anti-N positivity most observed steady increase followed by sharp after surge early 2022. Our data demonstrate burden specific groups health disparities within our region throughout pandemic. IMPORTANCE results highlight importance seropositivity essential tools provide information incidence prevalence seropositivity. also reinforce other reports demonstrating inequitable that this continued persist pandemic, even high adherence mitigation efforts. It highlights SVI’s value identifying communities must be part research, public vaccination strategies.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Jan. 5, 2024
Abstract This study used repeat serologic testing to estimate infection rates and risk factors in two overlapping cohorts of SARS-CoV-2 N protein seronegative U.S. adults. One mostly unvaccinated sub-cohort was tracked from April 2020 March 2021 (pre-vaccine/wild-type era, n = 3421), the other, vaccinated cohort, June 2022 (vaccine/variant 2735). Vaccine uptake 0.53% 91.3% pre-vaccine vaccine/variant cohorts, respectively. Corresponding seroconversion were 9.6 25.7 per 100 person-years. In both sociodemographic epidemiologic for similar, though new emerged such as having a child household. Despite higher incidence vaccine boosters, masking, social distancing associated with substantially reduced risk, even through major variant surges.
Language: Английский
Citations
1
Influenza and Other Respiratory Viruses, Journal Year: 2024, Volume and Issue: 18(10)
Published: Oct. 1, 2024
ABSTRACT Objectives The aim of this study is to determine the incidence and risk factors associated with COVID‐19 hospitalization among unvaccinated children. Methods Children aged 0– < 18 years, members Kaiser Permanente Northern California (KPNC), were followed from March 1, 2020, until earliest occurrence of: chart‐confirmed hospitalization, disenrollment KPNC, age receipt vaccine, death, or end (December 31, 2022). We calculated rate by SARS‐CoV‐2 variant period group. determined for using Poisson regression. also conducted descriptive analyses hospitalized cases. Results Among 1,107,799 children, 423 during follow‐up. increased each new was highest children 6 months. 6‐month‐olds, per 100,000 person‐months 7 predelta, 13.3 delta, 22.4 omicron. Black (RR = 2.05, 95% CI: 1.33–3.16) Hispanic 1.82, 1.34–2.46) any comorbidities at high 3.81, 2.94–4.95). Overall, 20.3% admitted an intensive care unit (ICU), but ICU admission 36.1% 12– 18‐year‐olds. majority admits (91.8%) had no comorbidities. Conclusion too young be vaccinated while adolescents proportion admissions. To prevent severe disease in adolescents, everyone eligible should vaccinated.
Language: Английский
Citations
1
Emerging infectious diseases, Journal Year: 2023, Volume and Issue: 29(8)
Published: July 13, 2023
We estimated SARS-CoV-2 seroprevalence in children Oregon, USA, at 6 time points. Seroprevalence increased linearly during November 2020-December 2021 and peaked February 2022 38.8% (95% CI 32.8%-46.5%). observed no increase the trend after widespread school reopening. estimates complement case-based cumulative incidence.
Language: Английский
Citations
2
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 2, 2023
Infectious disease surveillance systems, which largely rely on diagnosed cases, underestimate the true incidence of SARS-CoV-2 infection, due to under-ascertainment and underreporting. We used repeat serologic testing measure N-protein seroconversion in a well-characterized cohort U.S. adults with no evidence infection estimate characterize risk factors, comparisons before after start vaccine variant eras.
Language: Английский
Citations
1
Medicina, Journal Year: 2024, Volume and Issue: 60(3), P. 384 - 384
Published: Feb. 24, 2024
Background and Objectives: The aim of this research was to assess the spread SARS-CoV-2 infection; study motivated by parental hesitancy regarding child vaccination, potential passive immunity infants acquired through breastfeeding from mothers vaccinated against COVID-19 or infected with SARS-CoV-2. Materials Methods: We quantified anti-SARS-CoV-2 immunoglobulin G (IgG) titer in serum 743 children under 5 years old, hospitalized between 1 August 2022, 15 September 2023. Results: Among participants, 52.76% had an IgG that exceeded reactivity threshold kit used, average 1558.01 U/mL across entire group. By age-specific categories, antibody prevalence 43.04% for 0–12 months, 42.22% 12–24 61.67% 24–36 65.17% 36–48 68.55% 48–59 months. Gender analysis revealed 55.32% male a 52.07% seropositivity rate. Notably, correlated positively child’s age. Gender, admission diagnosis, emergency department presentation were not variation factors titer. Conclusions: majority group demonstrated SARS-CoV-2, rate increased Also,
Language: Английский
Citations
0
Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(8)
Published: Aug. 1, 2024
To elucidate the seroprevalence and rate of asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Japanese children, serological analysis was performed using serum samples collected from March 2020 to February 2023. A total 1493 were during first study period (March 2021). None positive for SARS-CoV-2 antibody. In second 2021 2022), seven 1055 patients (0.7%) experienced infection. The third 2022 2023) divided into three terms: June 30, 2022; July October November gradually increased throughout this period, rates 6.0%, 18.6%, 30.4% terms, respectively. Pediatric cases occurred after surge Omicron variants. Since none antibody-positive had a previous history disease 2019, may represent
Language: Английский
Citations
0
Open Forum Infectious Diseases, Journal Year: 2024, Volume and Issue: 12(1)
Published: Dec. 23, 2024
Abstract Background Household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may play a key role in times increased infection, particularly among children. We aimed to determine the prevalence SARS-CoV-2 antibodies and identify risk factors associated with antibody positivity Methods Unvaccinated children aged 18 months 11 years between August 2022 June 2023 underwent oral fluid testing for antibodies. Caregivers completed electronic surveys at 4 major healthcare practices Northern Central New Jersey. Information was collected on demographics, household size, vaccination status, prior SARS-CoV-2–related illness. Multivariable logistic regression determined individual household-level positivity. Results A total 870 provided tests corresponding surveys. Children were predominantly Hispanic (37%) or non-Hispanic Black (30%), average 5.7 old. Overall 68%. Risk include race/ethnicity (adjusted odds ratios [aOR], 2.29 1.95 vs. White race/ethnicity; P < .01) later enrollment study period. from households ≥1 vaccinated adult 52% less likely be positive than those no adults (aOR: 0.38, [95% confidence interval 0.2 0.69]). Conclusions There is high burden infection over time. Adult appears protective factor helping mitigate disease 2019 (COVID-19) Increased community can help inform COVID-19 prevention strategies minors household.
Language: Английский
Citations
0
Microorganisms, Journal Year: 2023, Volume and Issue: 11(12), P. 2919 - 2919
Published: Dec. 4, 2023
The occurrence of SARS-CoV-2 infections during the pandemic was mainly based on PCR testing symptomatic patients. However, with new variants, vaccinations, and changing clinical disease severity, knowledge about general immunity is elusive. For public health systems, timely these conditions essential, but it particularly scarce for pediatric population. Therefore, in this study, we wanted to investigate spike nucleocapsid seroprevalence patients using routine residual blood tests collected pandemic. This prospective observational study conducted over seven one-month periods. Herein, latest four time periods (November 2021, January 2022, March May 2022) are depicted. Each patient a tertiary-care center Germany anonymized after collection diagnosis (ICD-10) then routinely tested respective antibody titer. A total 3235 samples from were included. Spike rose 37.6% 51.9% 70.5% 85.1% 11.6% 17.0% 36.7% 58.1% 2022. In detail, significant changes between age groups not sex or found. Quantitative measures revealed rising constant levels half-life 102 days 45 antibodies. Routine laboratory assessment specimens hospitals enables monitoring may allow inferences cohort.
Language: Английский
Citations
0