A study on the impact of acute exercise on cognitive function in Alzheimer's disease or mild cognitive impairment patients: A narrative review

Geriatric Nursing, Journal Year: 2024, Volume and Issue: 59, P. 215 - 222

Published: July 24, 2024

This narrative review follows the JBI approach and comprehensively explores effects mechanisms of acute exercise on cognitive function in Alzheimer's disease (AD) Mild impairment (MCI) patients. The results showed that combination training improved AD patients better than aerobic or resistance alone. For with MCI, moderate intensity were beneficial to enhance Inhibitory control (IC), but high-intensity was adverse improve IC; Brain-derived neurotrophic factor (BDNF) Insulin-like growth 1 (IGF-1) may assume potential mediating mechanism MCI patients, more research is needed further confirm this mechanism.

Language: Английский

Running throughout Middle-Age Keeps Old Adult-Born Neurons Wired

eNeuro, Journal Year: 2023, Volume and Issue: 10(5), P. ENEURO.0084 - 23.2023

Published: May 1, 2023

Exercise may prevent or delay aging-related memory loss and neurodegeneration. In rodents, running increases the number of adult-born neurons in dentate gyrus (DG) hippocampus, association with improved synaptic plasticity function. However, it is unclear whether remain fully integrated into hippocampal network during aging long-term affects their connectivity. To address this issue, we labeled proliferating DG neural progenitor cells retrovirus expressing avian TVA receptor two-month-old sedentary male C57Bl/6 mice. More than six months later, injected EnvA-pseudotyped rabies virus as a monosynaptic retrograde tracer, to selectively infect "old" new neurons. We identified quantified direct afferent inputs these within hippocampus (sub)cortical areas. Here, show that substantially modifies generated young adult mice, upon middle-age. input from interneurons onto neurons, which play role reducing hyperexcitability. addition, prevents neuron innervation perirhinal cortex, subiculum entorhinal brain areas are essential for contextual spatial memory. Thus, maintains wiring born early adulthood, important function aging.

Language: Английский

Various modalities of resistance exercise promote similar acute cognitive improvements and hemodynamic increases in young, healthy adults

Cerebral Circulation - Cognition and Behavior, Journal Year: 2024, Volume and Issue: 7, P. 100363 - 100363

Published: Jan. 1, 2024

The aim was to examine the effects of modalities acute resistance exercise (RE) on cognition and hemodynamics including internal carotid artery (ICA) blood flow (BF). Twenty adults completed familiarization experimental visits. One-repetition maximum (1RM) for bilateral leg extension quantified, baseline executive functioning determined from three run-in Subsequent visits included randomized, volume-equated, bouts 30 %1RM+blood restriction (BFR), %1RM, 70 %1RM. Both %1RM trials four sets (1 × 30, 3 15), condition 8 repetitions. BFR induced with 40 % pressure occlude femoral arteries. 11 min following each exercise, participants Stroop Shifting Attention Tests. Baseline post-exercise values were used calculate change scores. resulting mean scores evaluated mixed factorial ANOVAs. A p≤0.05 considered significant. All measured outcome variables increased in response exercise. ANOVAs cognitive indicated no significant (p>0.05) interactions. For flexibility function index, there main Sex. Change females significantly greater than males (7.6 ± 5.9 vs. -2.6 8.4 au; p=0.007) index (7.4 4.6 -2.5 6.5 p=0.001). ICA BF, interaction or any effect. exhibited a smaller exercise-induced increase compared (17.7 11.0 4.1 mmHg; p=0.010). Each RE modality yielded improvements cognition, but only females. There related such that bout similar results.

Language: Английский