Trans- and Cis-Phosphorylated Tau Protein: New Pieces of the Puzzle in the Development of Neurofibrillary Tangles in Post-Ischemic Brain Neurodegeneration of the Alzheimer’s Disease-like Type

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3091 - 3091

Published: March 7, 2024

Recent evidence indicates that experimental brain ischemia leads to dementia with an Alzheimer's disease-like type phenotype and genotype. Based on the above evidence, it was hypothesized may contribute development of disease. Brain disease are two diseases characterized by similar changes in hippocampus closely related memory impairment. Following animals humans, presence amyloid plaques extracellular space intracellular neurofibrillary tangles revealed. The phenomenon tau protein hyperphosphorylation is a pathological feature both post-ischemic injury In disease, phosphorylated Thr231 motif has distinct trans cis conformations primary site phosphorylation pre-entanglement cascade acts as early precursor neuropathology form tangles. latest publication, we present mechanism formation after established trans- cis-phosphorylation protein, which ultimately influences tauopathy.

Language: Английский

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A Look at the Etiology of Alzheimer's Disease based on the Brain Ischemia Model

Current Alzheimer Research, Journal Year: 2024, Volume and Issue: 21(3), P. 166 - 182

Published: March 1, 2024

Alzheimer's disease (AD) is the frequent form of dementia in world. Despite over 100 years research into causes AD, including amyloid and tau protein, has stalled not led to any conclusions. Moreover, numerous projects aimed at finding a cure for AD have also failed achieve breakthrough. Thus, failure anti-amyloid anti-tau protein therapy treat significantly influenced way we began think about etiology disease. This situation prompted group researchers focus on ischemic brain episodes, which, like mostly present alterations hippocampus. In this context, it been proposed that cerebral incidents may play major role promoting neurodegeneration AD. review, summarized experimental clinical conducted several episodes development Studies shown changes typical course post-ischemia, i.e., progressive hippocampal atrophy, increased production, modification protein. post-ischemic brain, diffuse senile plaques neurofibrillary tangles characteristic were revealed. The above data evidently showed after ischemia, there are modifications folding, leading massive neuronal death damage network, which triggers with phenotype.

Language: Английский

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Decoding Alzheimer’s Disease: Single-Cell Sequencing Uncovers Brain Cell Heterogeneity and Pathogenesis

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

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Apolipoprotein (APOA1, APOE, CLU) genes expression in the CA3 region of the hippocampus in an ischemic model of Alzheimer's disease with survival up to 2 years

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Changes in the Alzheimer's disease-related apolipoprotein genes expression, occurring parallel with brain ischemia-induced neurodegeneration hippocampal CA3 area, may be crucial for development of memory loss and dementia.

Language: Английский

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